scholarly journals Biochemical propensity mapping for structural and functional anatomy of importin α IBB domain

2021 ◽  
Author(s):  
Kazuya Jibiki ◽  
Mo‐yan Liu ◽  
Chao‐sen Lei ◽  
Takashi S. Kodama ◽  
Chojiro Kojima ◽  
...  
Keyword(s):  
Functional Anatomy ◽  
Importin Α

scholarly journals Biochemical propensity mapping for structural and functional anatomy of importin α IBB domain

2021 ◽  
Author(s):  
Kazuya Jibiki ◽  
Moyan Liu ◽  
Lei Chaosen ◽  
Takashi S Kodama ◽  
Chojiro Kojima ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cell Fate ◽  
Protein Transport ◽  
Nuclear Transport ◽  
Control Cell ◽  
Functional Anatomy ◽  
Functional Domain ◽  
Binding Partners ◽  
Multiple Binding ◽  
Importin Α

Importin α has been described as a nuclear protein transport receptor that enables proteins synthesized in the cytoplasm to translocate into the nucleus. Besides its function in nuclear transport, an increasing number of studies have examined its non-nuclear transport functions. In both nuclear transport and non-nuclear transport, a functional domain called the IBB domain (importin b binding domain) plays a key role in regulating importin α behavior, and is a common interacting domain for multiple binding partners. However, it is not yet fully understood how the IBB domain interacts with multiple binding partners, which leads to the switching of importin α function that determines cell fate. In this study, we have distinguished the location and properties of amino acids important for each function of the importin α IBB domain by mapping the biochemical/physicochemical propensities of evolutionarily conserved amino acids of the IBB domain onto the structure associated with each function. We found important residues that are universally conserved for IBB functions across species and families, in addition to those previously known, as well as residues that are presumed to be responsible for the differences in complex-forming ability between families and for functional switching to control cell fate.

Functional Anatomy Underlying Pharyngeal Swallowing Mechanics and Swallowing Performance Goals

2019 ◽  
Vol 4 (4) ◽  
pp. 648-655
Author(s):  
William G. Pearson ◽  
Jacline V. Griffeth ◽  
Alexis M. Ennis
Keyword(s):  
Functional Anatomy ◽  
Neuromuscular Control ◽  
Upper Esophageal Sphincter ◽  
Performance Goals ◽  
Laryngeal Elevation ◽  
Port Closure ◽  
Swallowing Dysfunction ◽  
Hyoid Movement ◽  
Pharyngeal Swallowing ◽  
Pharyngeal Constriction

Purpose Rehabilitation of pharyngeal swallowing dysfunction requires a thorough understanding of the functional anatomy underlying the performance goals of pharyngeal swallowing. These goals include the safe and efficient transfer of a bolus through the hypopharynx into the esophagus. Penetration or aspiration of a bolus threatens swallowing safety. Bolus residue indicates swallowing inefficiency. Several primary mechanics, or elements of the swallowing mechanism, underlie these performance goals, with some elements contributing to both goals. These primary mechanics include velopharyngeal port closure, hyoid movement, laryngeal elevation, pharyngeal shortening, tongue base retraction, and pharyngeal constriction. Each element of the swallowing mechanism is under neuromuscular control and is therefore, in principle, a potential target for rehabilitation. Secondary mechanics of pharyngeal swallowing, those movements dependent on primary mechanics, include opening the upper esophageal sphincter and epiglottic inversion. Conclusion Understanding the functional anatomy of pharyngeal swallowing underlying swallowing performance goals will facilitate anatomically informed critical thinking in the rehabilitation of pharyngeal swallowing dysfunction.

Functional Anatomy of Intensity Aspects of Attention

2003 ◽  
Vol 14 (3) ◽  
pp. 181-190 ◽  
Author(s):  
Walter Sturm
Keyword(s):  
Right Hemisphere ◽  
Functional Anatomy ◽  
Fmri Data ◽  
Functional Networks ◽  
Top Down ◽  
Stimulus Modality ◽  
Spatial Orienting ◽  
Phasic Alertness ◽  
Co Activation ◽  
Attention System

Abstract: Behavioral and PET/fMRI-data are presented to delineate the functional networks subserving alertness, sustained attention, and vigilance as different aspects of attention intensity. The data suggest that a mostly right-hemisphere frontal, parietal, thalamic, and brainstem network plays an important role in the regulation of attention intensity, irrespective of stimulus modality. Under conditions of phasic alertness there is less right frontal activation reflecting a diminished need for top-down regulation with phasic extrinsic stimulation. Furthermore, a high overlap between the functional networks for alerting and spatial orienting of attention is demonstrated. These findings support the hypothesis of a co-activation of the posterior attention system involved in spatial orienting by the anterior alerting network. Possible implications of these findings for the therapy of neglect are proposed.

What Is Left Is Right

2009 ◽  
Vol 14 (1) ◽  
pp. 78-89 ◽  
Author(s):  
Kenneth Hugdahl ◽  
René Westerhausen
Keyword(s):  
Speech Processing ◽  
Information Transfer ◽  
Hemispheric Asymmetry ◽  
Functional Neuroimaging ◽  
Gray Matter Volume ◽  
Functional Anatomy ◽  
Posterior Part ◽  
Functional Asymmetry ◽  
Planum Temporale ◽  
Evolution Of Speech

The present paper is based on a talk on hemispheric asymmetry given by Kenneth Hugdahl at the Xth European Congress of Psychology, Praha July 2007. Here, we propose that hemispheric asymmetry evolved because of a left hemisphere speech processing specialization. The evolution of speech and the need for air-based communication necessitated division of labor between the hemispheres in order to avoid having duplicate copies in both hemispheres that would increase processing redundancy. It is argued that the neuronal basis of this labor division is the structural asymmetry observed in the peri-Sylvian region in the posterior part of the temporal lobe, with a left larger than right planum temporale area. This is the only example where a structural, or anatomical, asymmetry matches a corresponding functional asymmetry. The increase in gray matter volume in the left planum temporale area corresponds to a functional asymmetry of speech processing, as indexed from both behavioral, dichotic listening, and functional neuroimaging studies. The functional anatomy of the corpus callosum also supports such a view, with regional specificity of information transfer between the hemispheres.

Functional Anatomy of the Transplanted Heart

Circulation ◽  
1969 ◽  
Vol 39 (5s1) ◽  
Author(s):  
RICHARD J. CLEVELAND ◽  
J. MICHAEL CRILEY ◽  
RONALD J. NELSON ◽  
WILLIAM BRODY ◽  
DOMINIC DECRISTOFARO ◽  
...  
Keyword(s):  
Functional Anatomy

Functional anatomy of carnivorous traps

2018 ◽  
Author(s):  
Bartosz J. Płachno ◽  
Lyudmila E. Muravnik
Keyword(s):  
Current Knowledge ◽  
Functional Anatomy ◽  
Carnivorous Plant ◽  
Carnivorous Plants ◽  
New Type ◽  
Functional Units

We review the current knowledge of trap anatomy of carnivorous plants, with a focus on the diversity and structure of the glands that are used to attract, capture, kill and digest their prey and finally to absorb nutrients from carcasses of prey. These glands have diverse forms. Regardless of their structure and origin, they have the same functional units, but there are differences in subcellular mechanisms and adaptations for carnivory. We propose a new type of carnivorous plant trap—a ‘fecal traps—which has unique physiology, morphology, and anatomy for attracting the animals that are the source of excrement and also to retain and use it.

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