Sonic hedgehog signals hinder the transcriptional network necessary for pancreatic endoderm formation from human embryonic stem cells

2021 ◽  
Author(s):  
Niloufer P. Dumasia ◽  
Aparna P. Khanna ◽  
Prasad S. Pethe
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Transcriptional Network

scholarly journals Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

Development ◽  
2009 ◽  
Vol 136 (23) ◽  
pp. 4055-4063 ◽  
Author(s):  
X.-J. Li ◽  
X. Zhang ◽  
M. A. Johnson ◽  
Z.-B. Wang ◽  
T. LaVaute ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells

2014 ◽  
Vol 42 (8) ◽  
pp. S50
Author(s):  
Pablo Menendez ◽  
Miguel Toscano ◽  
Oscar Navarro-Montero ◽  
Veronica Ayllon ◽  
Veronica Ramos-Mejia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Transcriptional Network

scholarly journals SCL/TAL1-mediated Transcriptional Network Enhances Megakaryocytic Specification of Human Embryonic Stem Cells

2015 ◽  
Vol 23 (1) ◽  
pp. 158-170 ◽  
Author(s):  
Miguel G Toscano ◽  
Oscar Navarro-Montero ◽  
Veronica Ayllon ◽  
Veronica Ramos-Mejia ◽  
Xiomara Guerrero-Carreno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Transcriptional Network

The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons

Biomaterials ◽  
2014 ◽  
Vol 35 (3) ◽  
pp. 941-948 ◽  
Author(s):  
Tandis Vazin ◽  
Randolph S. Ashton ◽  
Anthony Conway ◽  
Nikhil A. Rode ◽  
Susan M. Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Gabaergic Neurons

scholarly journals Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells

2010 ◽  
Vol 4 (1) ◽  
pp. 38-49 ◽  
Author(s):  
Selena Meiyun Wu ◽  
Andre B.H. Choo ◽  
Miranda G.S. Yap ◽  
Ken Kwok-Keung Chan
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Hedgehog Signaling ◽  
Embryonic Stem ◽  
Sonic Hedgehog Signaling

scholarly journals Histone H3 Lysine 56 Acetylation Is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells

2009 ◽  
Vol 33 (4) ◽  
pp. 417-427 ◽  
Author(s):  
Wei Xie ◽  
Chunying Song ◽  
Nicolas L. Young ◽  
Adam S. Sperling ◽  
Feng Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Histone H3 ◽  
Embryonic Stem ◽  
Transcriptional Network ◽  
The Core

scholarly journals TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

2021 ◽  
Author(s):  
Sushama Sivakumar ◽  
Shutao Qi ◽  
Ningyan Cheng ◽  
Adwait amod sathe ◽  
Mohammed Kanchwala ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Sonic Hedgehog ◽  
Human Embryonic Stem Cells ◽  
Hedgehog Signaling ◽  
Neural Progenitor Cells ◽  
Embryonic Stem ◽  
Low Grade ◽  
Shh Signaling

Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Here, we probe the potential links among these cancer traits by inactivating TP53 in human embryonic stem cells (hESCs). TP53 knockout hESCs exhibit increased proliferation rates, mitotic errors, and low-grade structural aneuploidy; produce poorly differentiated immature teratomas in mice; and fail to differentiate into neural progenitor cells (NPC) in vitro. Genome-wide CRISPR screen reveals requirements of ciliogenesis and sonic hedgehog (Shh) pathways for hESC differentiation into NPCs. TP53 deletion causes abnormal ciliogenesis in neural rosettes. In addition to restraining cell proliferation through CDKN1A, TP53 activates the transcription of BBS9, which encodes a ciliogenesis regulator required for proper Shh signaling and NPC formation. This developmentally regulated transcriptional program of TP53 promotes ciliogenesis, restrains Shh signaling, and commits hESCs to neural lineages.

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