scholarly journals Role of TrkA signaling during tadpole tail regeneration and early embryonic development in Xenopus laevis

2019 ◽  
Vol 25 (2) ◽  
pp. 86-99 ◽  
Author(s):  
Akira Iimura ◽  
Eisuke Nishida ◽  
Morioh Kusakabe
Keyword(s):  
Embryonic Development ◽  
Xenopus Laevis ◽  
Early Embryonic Development ◽  
Tail Regeneration ◽  
Tadpole Tail

scholarly journals Changes in Acetyl CoA Levels during the Early Embryonic Development of Xenopus laevis

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97693 ◽  
Author(s):  
Yugo Tsuchiya ◽  
Uyen Pham ◽  
Wanzhou Hu ◽  
Shin-ichi Ohnuma ◽  
Ivan Gout
Keyword(s):  
Embryonic Development ◽  
Xenopus Laevis ◽  
Early Embryonic Development ◽  
Acetyl Coa

Chromosome length and DNA loop size during early embryonic development of Xenopus laevis

Chromosoma ◽  
1993 ◽  
Vol 102 (7) ◽  
pp. 478-483 ◽  
Author(s):  
Gioacchino Micheli ◽  
Anna Rosa Ciofi Luzzatto ◽  
Maria Teresa Carr� ◽  
Adriana de Capoa ◽  
Franca Pelliccia
Keyword(s):  
Embryonic Development ◽  
Xenopus Laevis ◽  
Chromosome Length ◽  
Early Embryonic Development ◽  
Loop Size ◽  
Dna Loop

scholarly journals The role of apoptosis in early embryonic development of the adenohypophysis in rats

2008 ◽  
Vol 4 (1) ◽  
Author(s):  
Jens Weingärtner ◽  
Kristina Lotz ◽  
Andreas Faltermeier ◽  
Oliver Driemel ◽  
Johannes Kleinheinz ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Early Embryonic Development

scholarly journals Role of bone morphogenetic protein signaling in bovine early embryonic development and stage specific embryotropic actions of follistatin†

2020 ◽  
Vol 102 (4) ◽  
pp. 795-805 ◽  
Author(s):  
Sandeep K Rajput ◽  
Chunyan Yang ◽  
Mohamed Ashry ◽  
Joseph K Folger ◽  
Jason G Knott ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Bone Morphogenetic Proteins ◽  
Mammalian Species ◽  
Cell Lineage ◽  
Bmp Signaling ◽  
Early Embryonic Development ◽  
Protein Signaling ◽  
Bovine Embryos ◽  
Embryonic Genome

Abstract Characterization of the molecular factors regulating early embryonic development and their functional mechanisms is critical for understanding the causes of early pregnancy loss in monotocous species (cattle, human). We previously characterized a stage specific functional role of follistatin, a TGF-beta superfamily binding protein, in promoting early embryonic development in cattle. The mechanism by which follistatin mediates this embryotropic effect is not precisely known as follistatin actions in cattle embryos are independent of its classically known activin inhibition activity. Apart from activin, follistatin is known to bind and modulate the activity of the bone morphogenetic proteins (BMPs), which signal through SMAD1/5 pathway and regulate several aspects of early embryogenesis in other mammalian species. Present study was designed to characterize the activity and functional requirement of BMP signaling during bovine early embryonic development and to investigate if follistatin involves BMP signaling for its stage specific embryotropic actions. Immunostaining and western blot analysis demonstrated that SMAD1/5 signaling is activated after embryonic genome activation in bovine embryos. However, days 1–3 follistatin treatment reduced the abundance of phosphorylated SMAD1/5 in cultured embryos. Inhibition of active SMAD1/5 signaling (8–16 cell to blastocyst) using pharmacological inhibitors and/or lentiviral-mediated inhibitory SMAD6 overexpression showed that SMAD1/5 signaling is required for blastocyst production, first cell lineage determination as well as mRNA and protein regulation of TE (CDX2) cell markers. SMAD1/5 signaling was also found to be essential for embryotropic actions of follistatin during days 4–7 but not days 1–3 of embryo development suggesting a role for follistatin in regulation of SMAD1/5 signaling in bovine embryos.

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