scholarly journals Spiral ganglion cell degeneration‐induced deafness as a consequence of reduced GATA factor activity

2019 ◽  
Vol 24 (8) ◽  
pp. 534-545
Author(s):  
Tomofumi Hoshino ◽  
Tsumoru Terunuma ◽  
Jun Takai ◽  
Satoshi Uemura ◽  
Yasuhiro Nakamura ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Spiral Ganglion ◽  
Factor Activity ◽  
Gata Factor ◽  
Cell Degeneration ◽  
Spiral Ganglion Cell

Chronic electrical stimulation does not prevent spiral ganglion cell degeneration in deafened guinea pigs

2010 ◽  
Vol 269 (1-2) ◽  
pp. 169-179 ◽  
Author(s):  
Martijn J.H. Agterberg ◽  
Huib Versnel ◽  
John C.M.J. de Groot ◽  
Marloes van den Broek ◽  
Sjaak F.L. Klis
Keyword(s):  
Electrical Stimulation ◽  
Ganglion Cell ◽  
Guinea Pigs ◽  
Spiral Ganglion ◽  
Cell Degeneration ◽  
Spiral Ganglion Cell ◽  
Chronic Electrical Stimulation

Electrocochleographic Changes in Endolymphatic Hydrops Induced by Type II Collagen Immunization through the Stylomastoid Foramen

1989 ◽  
Vol 98 (7) ◽  
pp. 556-562 ◽  
Author(s):  
Toru Ohashi ◽  
Koichi Tomoda ◽  
Nobuo Yoshie
Keyword(s):  
Ganglion Cell ◽  
Guinea Pigs ◽  
Endolymphatic Hydrops ◽  
Spiral Ganglion ◽  
Type Ii Collagen ◽  
Ménière’S Disease ◽  
Type Ii ◽  
Cell Degeneration ◽  
Stylomastoid Foramen ◽  
Spiral Ganglion Cell

Changes in action potential (AP) and summating potential (SP) were investigated in guinea pigs immunized with type II collagen through the stylomastoid foramen. Endolymphatic hydrops could be induced in four of 11 guinea pigs. The striking feature of the electrocochleographic waveform in guinea pigs with endolymphatic hydrops was the negative SP recording in response to high frequency tone bursts. Furthermore, abnormal changes in AP were observed in three of four hydropic guinea pigs. Morphologic study of the cochleas in these three guinea pigs with light microscopy revealed spiral ganglion cell degeneration in addition to endolymphatic hydrops and almost normal sensory hair cells. These results suggest that guinea pigs with hydrops as produced by our procedure can serve as a useful model of Meniere's disease, that autoimmune response may play an important role in the etiopathogenesis of Meniere's disease, and that spiral ganglion cell degeneration together with endolymphatic hydrops seems to contribute to abnormal changes in AP.

Acute Spiral Ganglion Cell Degeneration following Acoustic Overstimulation: An Experimental Study

ORL ◽  
2011 ◽  
Vol 73 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Görkem Eskiizmir ◽  
Ali Vefa Yücetürk ◽  
Sevinç İnan ◽  
Seren Gülşen Gürgen
Keyword(s):  
Experimental Study ◽  
Ganglion Cell ◽  
Spiral Ganglion ◽  
Cell Degeneration ◽  
Spiral Ganglion Cell ◽  
Acoustic Overstimulation

Brainstem Histopathology following Chronic Scala Tympani Implantation in Monkeys

1980 ◽  
Vol 89 (2_suppl) ◽  
pp. 15-17 ◽  
Author(s):  
Josef M. Miller ◽  
Dwight Sutton ◽  
Douglas B. Webster
Keyword(s):  
Ganglion Cell ◽  
Inferior Colliculus ◽  
Spiral Ganglion ◽  
Scala Tympani ◽  
Survival Times ◽  
Cell Degeneration ◽  
Transneuronal Degeneration ◽  
Spiral Ganglion Cell ◽  
Cochlear Nuclei

Degeneration in brainstem auditory nuclei was studied in monkeys following chronic implantation with scala tympani multielectrode systems. Nauta and Fink/Heimer-stained material from animals with survival × to 16 months were studied. The density and distribution of degeneration in the cochlear nuclei were consistent with observed patterns of spiral ganglion cell degeneration. Transneuronal degeneration was seen up to the level of the inferior colliculus. The density and form of the degeneration material in animals of varying survival times was consistent with the interpretation that a process of continuing degeneration occurred in these implanted ears.

Cochlear spiral ganglion cell degeneration in wild-caught mice as a function of age

1996 ◽  
Vol 100 (1-2) ◽  
pp. 101-106 ◽  
Author(s):  
Stefan Dazert ◽  
Martin L. Feldman ◽  
Elizabeth M. Keithley
Keyword(s):  
Ganglion Cell ◽  
Spiral Ganglion ◽  
Cell Degeneration ◽  
Spiral Ganglion Cell ◽  
Cochlear Spiral Ganglion

scholarly journals Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss

1997 ◽  
Vol 15 (4-5) ◽  
pp. 631-643 ◽  
Author(s):  
Josef M. Miller ◽  
David H. Chi ◽  
Leonard J. O'Keeffe ◽  
Paul Kruszka ◽  
Yehoash Raphael ◽  
...  
Keyword(s):  
Hair Cell ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Spiral Ganglion ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Inner Hair Cell ◽  
Spiral Ganglion Cell
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