scholarly journals Ric-8A, an activator protein of Gαi, controls mammalian epithelial cell polarity for tight junction assembly and cystogenesis

2017 ◽  
Vol 22 (3) ◽  
pp. 293-309 ◽  
Author(s):  
Kanako Chishiki ◽  
Sachiko Kamakura ◽  
Junya Hayase ◽  
Hideki Sumimoto
Keyword(s):  
Epithelial Cell ◽  
Tight Junction ◽  
Cell Polarity ◽  
Epithelial Cell Polarity ◽  
Activator Protein

scholarly journals Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity

Cell Reports ◽  
2020 ◽  
Vol 31 (1) ◽  
pp. 107407
Author(s):  
Kazunori Sasaki ◽  
Noriko Kojitani ◽  
Hiroko Hirose ◽  
Yohei Yoshihama ◽  
Hidefumi Suzuki ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Tight Junction ◽  
Cell Polarity ◽  
Epithelial Cell Polarity ◽  
Tight Junction Formation ◽  
Junction Formation

scholarly journals The MAGUK Protein MPP7 Binds to the Polarity Protein hDlg1 and Facilitates Epithelial Tight Junction Formation

2007 ◽  
Vol 18 (5) ◽  
pp. 1744-1755 ◽  
Author(s):  
Volker M. Stucke ◽  
Evy Timmerman ◽  
Joel Vandekerckhove ◽  
Kris Gevaert ◽  
Alan Hall
Keyword(s):  
Epithelial Cell ◽  
Tight Junction ◽  
Tight Junctions ◽  
Cell Polarity ◽  
Functional Organization ◽  
Epithelial Cell Polarity ◽  
Tight Junction Formation ◽  
Evolutionarily Conserved ◽  
Junction Formation ◽  
Epithelial Tight Junction

Three groups of evolutionarily conserved proteins have been implicated in the establishment of epithelial cell polarity: the apically-localized proteins of the Par (Par3-Par6-aPKC-Cdc42) and Crumbs groups (Crb3-PALS1-PATJ) and the basolaterally localized proteins of the Dlg group (Dlg1-Scribble-Lgl). During epithelial morphogenesis, these proteins participate in a complex network of interdependent interactions that define the position and functional organization of adherens junctions and tight junctions. However, the biochemical pathways through which they control polarity are poorly understood. In this study, we identify an interaction between endogenous hDlg1 and MPP7, a previously uncharacterized MAGUK-p55 subfamily member. We find that MPP7 targets to the lateral surface of epithelial cells via its L27N domain, through an interaction with hDlg1. Loss of either hDlg1 or MPP7 from epithelial Caco-2 cells results in a significant defect in the assembly and maintenance of functional tight junctions. We conclude that the formation of a complex between hDlg1 and MPP7 promotes epithelial cell polarity and tight junction formation.

scholarly journals SEGGA: a toolset for rapid automated analysis of epithelial cell polarity and dynamics

Development ◽  
2017 ◽  
Vol 144 (9) ◽  
pp. 1725-1734 ◽  
Author(s):  
Dene L. Farrell ◽  
Ori Weitz ◽  
Marcelo O. Magnasco ◽  
Jennifer A. Zallen
Keyword(s):  
Epithelial Cell ◽  
Cell Polarity ◽  
Automated Analysis ◽  
Epithelial Cell Polarity
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