scholarly journals Octopamine enhances oxidative stress resistance through the fasting-responsive transcription factor DAF-16/FOXO in C. elegans

2017 ◽  
Vol 22 (2) ◽  
pp. 210-219 ◽  
Author(s):  
Haruka Hoshikawa ◽  
Masaharu Uno ◽  
Sakiko Honjoh ◽  
Eisuke Nishida
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Stress Resistance ◽  
Oxidative Stress Resistance ◽  
C Elegans

scholarly journals A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: The transcription factor CgTog1

Virulence ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 1522-1538
Author(s):  
Pedro Pais ◽  
Susana Vagueiro ◽  
Dalila Mil-Homens ◽  
Andreia I. Pimenta ◽  
Romeu Viana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Stress Resistance ◽  
Candida Glabrata ◽  
Oxidative Stress Resistance

scholarly journals Gengnianchun, a Traditional Chinese Medicine, Enhances Oxidative Stress Resistance and Lifespan in Caenorhabditis elegans by Modulating daf-16/FOXO

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Fanhui Meng ◽  
Jun Li ◽  
Wenjun Wang ◽  
Yan Fu
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Stress Resistance ◽  
Transgenic Animals ◽  
Wild Type ◽  
Oxidative Stress Resistance ◽  
C Elegans ◽  
And Oxidative Stress

Objective. Gengnianchun (GNC), a traditional Chinese medicine (TCM), is primarily used to improve declining functions related to aging. In this study, we investigated its prolongevity and stress resistance properties and explored the associated regulatory mechanism using a Caenorhabditis elegans model. Methods. Wild-type C. elegans N2 was used for lifespan analysis and oxidative stress resistance assays. Transgenic animals were used to investigate pathways associated with antioxidative stress activity. The effects of GNC on levels of reactive oxygen species (ROS) and expression of specific genes were examined. Results. GNC-treated wild-type worms showed an increase in survival time under both normal and oxidative stress conditions. GNC decreased intracellular ROS levels by 67.95%. GNC significantly enhanced the oxidative stress resistance of several mutant strains, suggesting that the protective effect of GNC is independent of the function of these genes. However, the oxidative stress resistance effect of GNC was absent in worms with daf-16 mutation. We also found upregulation of daf-16 downstream targets including sod-3 and mtl-1. Conclusions. Our findings suggest that GNC extends the lifespan of C. elegans and enhances its resistance to oxidative stress via a daf-16/FOXO-dependent pathway. This study also provides a feasible method for screening the biological mechanisms of TCMs.

scholarly journals Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Chatrawee Duangjan ◽  
Panthakarn Rangsinth ◽  
Xiaojie Gu ◽  
Michael Wink ◽  
Tewin Tencomnao
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Anacardium Occidentale ◽  
Leaf Extracts ◽  
Oxidative Stress Resistance ◽  
C Elegans ◽  
Pharyngeal Pumping ◽  
Antioxidative Stress ◽  
Underlying Mechanisms

Anacardium occidentale (AO) contains a number of polyphenolic secondary metabolites with antioxidant activity. The objectives of this study were aimed at investigating the roles of AO leaf extracts in antioxidative stress and longevity, as well as their underlying mechanisms, in the Caenorhabditis elegans (C. elegans) model. AO extracts mediated the survival rate of nematodes under oxidative stress by attenuating intracellular reactive oxygen species (ROS) via the DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. AO extracts stimulated the expression of stress response genes including SOD-3 and GST-4. Moreover, AO extracts exhibited antiaging activities and enhanced longevity. We observed improved pharyngeal pumping function, attenuation of pigment accumulation (lipofuscin), and an increased lifespan of the worms. Collectively, our results demonstrated that AO extracts exerted both oxidative stress resistance and antiaging properties in the C. elegans model and may lead to new agents to benefit humans in the near future.

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