scholarly journals Disappearance of centroacinar cells in the Notch ligand-deficient pancreas

2015 ◽  
Vol 20 (6) ◽  
pp. 500-511 ◽  
Author(s):  
Yasuhiro Nakano ◽  
Naoko Negishi ◽  
Seiho Gocho ◽  
Tetsuya Mine ◽  
Yuri Sakurai ◽  
...  
Keyword(s):  
Notch Ligand ◽  
Centroacinar Cells

scholarly journals Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1

Genetics ◽  
2016 ◽  
Vol 202 (3) ◽  
pp. 1119-1133 ◽  
Author(s):  
K. Schuster-Gossler ◽  
R. Cordes ◽  
J. Muller ◽  
I. Geffers ◽  
P. Delany-Heiken ◽  
...  
Keyword(s):  
Structural Integrity ◽  
Notch Ligand ◽  
Context Dependent

scholarly journals Notch ligand Delta-like 1 promotes in vivo vasculogenesis in human cord blood–derived endothelial colony forming cells

Cytotherapy ◽  
2015 ◽  
Vol 17 (5) ◽  
pp. 579-592 ◽  
Author(s):  
Hyojin Kim ◽  
Lan Huang ◽  
Paul J. Critser ◽  
Zhenyun Yang ◽  
Rebecca J. Chan ◽  
...  
Keyword(s):  
Cord Blood ◽  
Human Cord Blood ◽  
Notch Ligand ◽  
Endothelial Colony Forming Cells

Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling

2000 ◽  
Vol 113 (23) ◽  
pp. 4313-4318 ◽  
Author(s):  
B. Varnum-Finney ◽  
L. Wu ◽  
M. Yu ◽  
C. Brashem-Stein ◽  
S. Staats ◽  
...  
Keyword(s):  
Cell Fate ◽  
Extracellular Domain ◽  
Notch Ligand ◽  
Cell Fate Decisions ◽  
Plastic Surface ◽  
Ligand Stabilization ◽  
Potential Activity ◽  
Inhibition Of Differentiation ◽  
Notch Ligands ◽  
Notch Activation

Cell-cell interactions mediated by Notch and its ligands are known to effect many cell fate decisions in both invertebrates and vertebrates. However, the mechanisms involved in ligand induced Notch activation are unknown. Recently it was shown that, in at least some cases, endocytosis of the extracellular domain of Notch and ligand by the signaling cell is required for signal induction in the receptive cell. These results imply that soluble ligands (ligand extracellular domains) although capable of binding Notch would be unlikely to activate it. To test the potential activity of soluble Notch ligands, we generated monomeric and dimeric forms of the Notch ligand Delta-1 by fusing the extracellular domain to either a series of myc epitopes (Delta-1(ext-myc)) or to the Fc portion of human IgG-1 (Delta-1(ext-IgG)), respectively. Notch activation, assayed by inhibition of differentiation in C2 myoblasts and by HES1 transactivation in U20S cells, occurred when either Delta-1(ext-myc) or Delta-1(ext-IgG) were first immobilized on the plastic surface. However, Notch was not activated by either monomeric or dimeric ligand in solution (non-immobilized). Furthermore, both non-immobilized Delta-1(ext-myc) and Delta-1(ext-IgG) blocked the effect of immobilized Delta. These results indicate that Delta-1 extracellular domain must be immobilized to induce Notch activation in C2 or U20S cells and that non-immobilized Delta-1 extracellular domain is inhibitory to Notch function. These results imply that ligand stabilization may be essential for Notch activation.

Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development

Development ◽  
1998 ◽  
Vol 125 (15) ◽  
pp. 2951-2962 ◽  
Author(s):  
T. Klein ◽  
A.M. Arias
Keyword(s):  
Notch Signalling ◽  
Dominant Negative ◽  
Wing Development ◽  
Notch Signalling Pathway ◽  
Notch Ligand ◽  
Drosophila Wing ◽  
Signalling Molecule ◽  
Dorsoventral Boundary ◽  
Notch Ligands ◽  
Specific Nuclear Protein

The Notch signalling pathway plays an important role during the development of the wing primordium, especially of the wing blade and margin. In these processes, the activity of Notch is controlled by the activity of the dorsal specific nuclear protein Apterous, which regulates the expression of the Notch ligand, Serrate, and the Fringe signalling molecule. The other Notch ligand, Delta, also plays a role in the development and patterning of the wing. It has been proposed that Fringe modulates the ability of Serrate and Delta to signal through Notch and thereby restricts Notch signalling to the dorsoventral boundary of the developing wing blade. Here we report the results of experiments aimed at establishing the relationships between Fringe, Serrate and Delta during wing development. We find that Serrate is not required for the initiation of wing development but rather for the expansion and early patterning of the wing primordium. We provide evidence that, at the onset of wing development, Delta is under the control of apterous and might be the Notch ligand in this process. In addition, we find that Fringe function requires Su(H). Our results suggest that Notch signalling during wing development relies on careful balances between positive and dominant negative interactions between Notch ligands, some of which are mediated by Fringe.

scholarly journals Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase–mutant Glioma

2018 ◽  
Vol 25 (4) ◽  
pp. 1261-1271 ◽  
Author(s):  
Marissa Spino ◽  
Sylvia C. Kurz ◽  
Luis Chiriboga ◽  
Jonathan Serrano ◽  
Briana Zeck ◽  
...  
Keyword(s):  
Cell Surface ◽  
Isocitrate Dehydrogenase ◽  
Therapeutic Target ◽  
Notch Ligand ◽  
Surface Notch

scholarly journals Neuralized-2 Regulates a Notch Ligand in Cooperation with Mind Bomb-1

2006 ◽  
Vol 281 (47) ◽  
pp. 36391-36400 ◽  
Author(s):  
Ran Song ◽  
Bon-Kyoung Koo ◽  
Ki-Jun Yoon ◽  
Mi-Jeong Yoon ◽  
Kyeong-Won Yoo ◽  
...  
Keyword(s):  
Notch Ligand
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