scholarly journals Effect of truncated neurokinin-1 receptor expression changes on the interaction between human breast cancer and bone marrow-derived mesenchymal stem cells

2014 ◽  
Vol 19 (9) ◽  
pp. 676-691 ◽  
Author(s):  
Yunli Zhou ◽  
Duo Zuo ◽  
Meng Wang ◽  
Yongci Zhang ◽  
Man Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Human Breast Cancer ◽  
Receptor Expression ◽  
Human Breast ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

scholarly journals Generation of Gene Engineered Mesenchymal Stem Cells and Its Efficacy against Human Breast Cancer

2013 ◽  
Vol 4 ◽  
Author(s):  
Fei Ling Yap ◽  
Soon Keng Cheong ◽  
Ammu Radhakrishnan ◽  
Chooi Fun Leong
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Breast Cancer ◽  
Human Breast

scholarly journals MicroRNA Regulation of Human Breast Cancer Stem Cells

2015 ◽  
Vol 5 (1) ◽  
pp. 2 ◽  
Author(s):  
Yohei Shimono ◽  
Junko Mukohyama ◽  
Shun-ichi Nakamura ◽  
Hironobu Minami
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Microrna Regulation

Exosomal MicroRNA-204 Derived from Bone Marrow Mesenchymal Stem Cells (BMSCs) Inhibits Cell Proliferation and Induces Apoptosis Through NF-κB Signaling Pathway in Breast Cancer

2022 ◽  
Vol 12 (2) ◽  
pp. 273-278
Author(s):  
Daqing Jiang ◽  
Xianxin Xie ◽  
Cong Wang ◽  
Weijie Li ◽  
Jianjun He
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Marrow Mesenchymal Stem Cells ◽  
Induced Apoptosis ◽  
Signaling Activation

Our study intends to assess the relationship between exosomes derived from bone marrow mesenchymal stem cells (BMSC-exo) and breast cancer. BMSC-exo were isolated and characterized by transmission electron microscopy. After transfection of BMSCs with miR-204 inhibitor, breast cancer cells were incubated with BMSC-exo followed by analysis of cell proliferation by CCK-8 assay, cell apoptosis by flow cytometry, and expression of apoptosis-related protein and NF-κB signaling by western blot. The co-culture of BMSC-exo with breast cancer cells enhanced miR-204 transcription, inhibited cell proliferation and induced apoptosis. Further, BMSC-exo accelerated apoptosis as demonstrated by the increased level of Bax and casepase-3 and decreased Bcl-2 expression, as well as reduced NF-κB signaling activity. But knockdown of miR-204 abolished the effect of BMSC-exo on apoptosis and proliferation with NF-κB signaling activation. In conclusion, miR-204 from BMSC-exo restrains growth of breast cancer cell and might be a novel target for treating breast cancer.

Sign in / Sign up

Export Citation Format

Share Document