Clenbuterol poisoning due to a mix‐up between clenbuterol hydrochloride and other similarly shaped drug tablets

Author(s):  
Seigo Urushidani ◽  
Akira Kuriyama
2009 ◽  
Vol 23 (5-6) ◽  
pp. 271-279 ◽  
Author(s):  
Yun Wu ◽  
Hui Mao ◽  
Bo Zhao ◽  
Jian Shen

The interaction of clenbuterol hydrochloride (CL) to bovine hemoglobin (BHb) under physiological conditions was investigated by using UV-vis absorption, fluorescence, circular dichroism (CD) and molecular modeling. The fluorescence intensity of BHb decreased regularly with the gradual increasing concentration of CL. It is observed that there was a prominent interaction between CL and BHb. The fluorescence data revealed that the fluorescence quenching is a static process, and the thermodynamic parameters were calculated according to the Van't Hoff equation. The alternations of protein secondary structure in the presence of CL were determined by the evidence of CD. Molecular modeling study that corroborate our experimental results revealed that the binding mode of CL–BHb complex could be attributed to the hydrophobic interaction and hydrogen bonding, but electronic interaction cannot be excluded.


2018 ◽  
Vol 46 (10) ◽  
pp. 1595-1603 ◽  
Author(s):  
Ge YANG ◽  
Chao ZHU ◽  
Xiao-Hui LIU ◽  
Yong WANG ◽  
Feng QU

The Analyst ◽  
2021 ◽  
Vol 146 (20) ◽  
pp. 6323-6332
Author(s):  
Xiang Li ◽  
Yangguang Li ◽  
Pai Yu ◽  
Yanbin Tong ◽  
Bang-Ce Ye

A molecularly imprinted polymer grown on a nitrogen-doped Fe-MOF modified glassy carbon electrode for the detection of clenbuterol hydrochloride and ractopamine in humans.


2011 ◽  
Vol 236-238 ◽  
pp. 1546-1548 ◽  
Author(s):  
Jin Gang Yu ◽  
Du Shu Huang

Resolution of clenbuterol hydrochloride enantiomers and propranolol hydrochloride enantiomers was achieved by thin-layer chromatography using methyl-β-cyclodextrin impregnated silica gel GF254 plates. The effects of stereoselective auxiliary (acetonitrile/different alcohols) were studied. Resolution of clenbuterol hydrochloride enantiomers could be realized by alcohols such as ethanol, n-butanol, 2-butanol or tert-butanol together with acetonitrile, and propranolol hydrochloride enantiomers could only be resoluted by ethanol or n-butanol together with acetonitrile. The optical conditions of simultaneous resolution were obtained as follows: 15.00g silica gel GF254 plates impregnated with 1.00g methyl-β-cyclodextrin, acetonitrile/n-butanol (V/V = 90:10) mixed solvent as spreading solvent, being resolved under ambient temperature. Under these conditions, RF value of resolution of clenbuterol hydrochloride enantiomers is 3.47, RF value of resolution of propranolol hydrochloride enantiomers is 3.35. The two couples of enantiomers were all achieved base line separation.


PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0122005 ◽  
Author(s):  
Jiandong Hu ◽  
Ruipeng Chen ◽  
Shun Wang ◽  
Tingting Wang ◽  
Yuanyuan Zhao ◽  
...  

2015 ◽  
Vol 7 (12) ◽  
pp. 4957-4964 ◽  
Author(s):  
ZhuanZhuan Shi ◽  
YunLi Tian ◽  
XiaoShuai Wu ◽  
ChangMing Li ◽  
Ling Yu

A one-piece lateral flow impedance strip was developed for detection of clenbuterol hydrochloride, a restricted food additive.


2013 ◽  
Vol 56 (4) ◽  
pp. 713-717 ◽  
Author(s):  
YuPing Yang ◽  
XiangYun Lei ◽  
Ai Yue ◽  
Zhenwei Zhang

Sign in / Sign up

Export Citation Format

Share Document