Korean mistletoe ( Viscum album var. coloratum ) extends the lifespan via FOXO activation induced by dSir2 in Drosophila melanogaster

2021 ◽  
Author(s):  
Shin‐Hae Lee ◽  
Hye‐Yeon Lee ◽  
Kyung‐Jin Min
Keyword(s):  
Drosophila Melanogaster ◽  
Viscum Album ◽  
Korean Mistletoe

Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumor cells

1999 ◽  
Vol 136 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Taek Joon Yoon ◽  
Yung Choon Yoo ◽  
Tae Bong Kang ◽  
Kei-ichi Shimazaki ◽  
Seong Kyu Song ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Viscum Album ◽  
Korean Mistletoe

scholarly journals Alterations in IL-6/STAT3 Signaling by Korean Mistletoe Lectin Regulate the Self-Renewal Activity of Placenta-Derived Mesenchymal Stem Cells

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2604 ◽  
Author(s):  
Kim ◽  
Choi ◽  
Lim ◽  
Jun ◽  
Moon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Viscum Album ◽  
The Self ◽  
Mistletoe Lectin ◽  
Gene Methylation ◽  
Self Renewal ◽  
Korean Mistletoe ◽  
Specific Pcr ◽  
Stat3 Signaling

Korean mistletoe (Viscum album L. var. coloratum) lectin (VCA) is known as an anticancer drug. However, it is not clear whether VCA affects the self-renewal activity of mesenchymal stem cells (MSCs). Therefore, the objectives of this study were to analyze the effect of VCA on the proliferation of MSCs and expression of stemness markers. We also evaluated the usefulness of placenta-derived MSCs (PD-MSCs) as a screening tool. VCA was stably administered to MSCs, and analyzed self-renewal activities. The effect of IL-6 signaling on MSC proliferation was explored by quantitative methylation-specific PCR (qMSP) and western blot analysis. Compared with the control condition, low concentrations of VCA (10 pg/mL) induced an increase in the self-renewal activity of MSCs. Interestingly, a low concentration of VCA promoted IL-6 signaling in PD-MSCs through altered IL-6/STAT3 gene methylation. Furthermore, inhibition of IL-6 expression in PD-MSCs using an anti-IL-6 antibody caused a decrease in their self-renewal activity through IL-6/STAT3 signaling by altering IL-6/STAT3 gene methylation. These findings provide helpful data for understanding the mechanism of MSC self-renewal via VCA and show that VCA may be useful as a functional natural product for developing efficient therapies using placenta-derived stem cells.

Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells

2000 ◽  
Vol 34 (5) ◽  
pp. 349-355 ◽  
Author(s):  
Myung-Sunny Kim ◽  
Hong-Seob So ◽  
Kang-Min Lee ◽  
Ji-Sun Park ◽  
Jae-Hoon Lee ◽  
...  
Keyword(s):  
Viscum Album ◽  
U937 Cells ◽  
Korean Mistletoe ◽  
Induced Apoptosis ◽  
Caspase Cascades

Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumor metastasis is mediated by enhancement of NK cell activity

1998 ◽  
Vol 20 (4-5) ◽  
pp. 163-172 ◽  
Author(s):  
Taek Joon Yoon ◽  
Yung Choon Yoo ◽  
Tae Bong Kang ◽  
Young Jin Baek ◽  
Chul Sung Huh ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Nk Cell ◽  
Cell Activity ◽  
Viscum Album ◽  
Prophylactic Effect ◽  
Nk Cell Activity ◽  
Korean Mistletoe
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