Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

2019 ◽  
Vol 19 (10) ◽  
pp. 1017-1022
Author(s):  
Chuan‐Wei Yang ◽  
Chia‐Ing Li ◽  
Chiu‐Shong Liu ◽  
Chih‐Hsueh Lin ◽  
Wen‐Yuan Lin ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Advanced Glycation End Products ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Community Dwelling Older Adults

scholarly journals Elevated level of the soluble receptor for advanced glycation end-products involved in sarcopenia: an observational study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shou-En Wu ◽  
Yi-Lin Chiu ◽  
Tung-Wei Kao ◽  
Wei-Liang Chen
Keyword(s):  
Muscle Mass ◽  
Advanced Glycation End Products ◽  
Community Dwelling ◽  
Enzyme Linked Immunosorbent Assay ◽  
Health Examination ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Srage Level ◽  
Glycation End Products ◽  
End Products

Abstract Background The soluble receptor for advanced glycation end products (sRAGE) has been proposed to serve as a marker for disease severity, but its role in sarcopenia, an age-related progressive loss of muscle mass and function, remains elusive. This study examines the association between sRAGE and sarcopenia. Methods A total of 314 community-dwelling elderly adults who had their health examination at Tri-Service General Hospital from 2017 to 2019 underwent protein analysis with enzyme-linked immunosorbent assay. The relationship with sarcopenia and its detailed information, including components and diagnosis status, were examined using linear and logistic regressions. Results As for sarcopenia components, low muscle mass (β = 162.8, p = 0.012) and strength (β = 181.31, p = 0.011) were significantly correlated with sRAGE, but not low gait speed (p = 0.066). With regard to disease status, confirmed sarcopenia (β = 436.93, p < 0.001), but not probable (p = 0.448) or severe sarcopenia (p = 0.488), was significantly correlated with sRAGE. In addition, females revealed a stronger association with sRAGE level by showing significant correlations with low muscle mass (β = 221.72, p = 0.014) and low muscle strength (β = 208.68, p = 0.043). Conclusions sRAGE level showed a positive association with sarcopenia, illustrating its involvement in the evolution of sarcopenia. This association is more evident in female groups, which may be attributed to the loss of protection from estrogen in postmenopausal women. Utilizing sRAGE level as a prospective marker for sarcopenia deserves further investigation in future studies.

scholarly journals Falls in Community-Dwelling Older Adults with Lower Back or Knee Pain Are Associated with Cognitive and Emotional Factors

2020 ◽  
Vol 17 (14) ◽  
pp. 4960
Author(s):  
Tatsuya Hirase ◽  
Hyuma Makizako ◽  
Yoshiro Okubo ◽  
Stephen R. Lord ◽  
Minoru Okita ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Weakness ◽  
Skeletal Muscle Mass ◽  
Depression Scale ◽  
Community Dwelling ◽  
Physical Factors ◽  
Emotional Factors ◽  
Community Dwelling Older Adults

(1) Background: The present study aimed to examine physical, cognitive and emotional factors affecting falls in community-dwelling older adults with and without pain; (2) Methods: Data from 789 older adults who participated in a community-based health survey were analyzed. Participants completed questionnaires on the presence of pain and previous falls. Muscle weakness (handgrip strength < 26.0 kg for men and < 18.0 kg for women) and low skeletal muscle mass (appendicular skeletal muscle mass index < 7.0 kg/m2 for men and < 5.7 kg/m2 for women) were determined. Mild cognitive impairment (MCI) and depressive symptoms were assessed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool and 15-item geriatric depression scale (GDS-15), respectively; (3) Results: In participants with pain, MCI and GDS-15 were associated with previous falls after adjusting for age, sex, education and medication use. In participants without pain, muscle weakness and low skeletal muscle mass were associated with previous falls when adjusting for the above covariates; (4) Conclusions: Falls in participants with pain were associated with cognitive and emotional factors, whereas falls in those without pain were associated with physical factors. Fall prevention interventions for older adults with pain may require tailored strategies to address cognitive and emotional factors.

scholarly journals The Relationship between Sarcopenia and Respiratory Muscle Weakness in Community-Dwelling Older Adults

2021 ◽  
Vol 18 (24) ◽  
pp. 13257
Author(s):  
Tomoyuki Morisawa ◽  
Yota Kunieda ◽  
Shingo Koyama ◽  
Mizue Suzuki ◽  
Yuma Takahashi ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Weakness ◽  
Respiratory Muscle ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Respiratory Muscle Weakness ◽  
Skeletal Muscle Index ◽  
Community Dwelling Older Adults

An association between respiratory muscle weakness and sarcopenia may provide a clue to the mechanism of sarcopenia development. We aimed to clarify this relationship among community-dwelling older adults. In total, 117 community-dwelling older adults were assessed and classified into 4 groups: robust, respiratory muscle weakness, sarcopenia, and respiratory sarcopenia. The respiratory sarcopenia group (12%) had a significantly higher percentage of males and had lower BMI, skeletal muscle index, skeletal muscle mass, phase angle, and oral function than the robust group (32.5%). All physical functions were significantly lower. The respiratory muscle weakness group (54.7%) had a significantly lower BMI and slower walking speed, compared with the robust group. The sarcopenia group (0.8%) was excluded from the analysis. The percent maximum inspiratory pressure was significantly lower in both the respiratory muscle weakness and respiratory sarcopenia groups, compared with the robust group. Almost all participants with sarcopenia showed respiratory muscle weakness. In addition, approximately 50% had respiratory muscle weakness, even in the absence of systemic sarcopenia, suggesting that respiratory muscle weakness may be the precursor of sarcopenia. The values indicating physical function and skeletal muscle mass in the respiratory muscle weakness group were between those in the robust and the respiratory sarcopenia groups.

scholarly journals Relationship between skeletal muscle mass and cardiac function during exercise in community-dwelling older adults

2017 ◽  
Vol 4 (4) ◽  
pp. 409-416 ◽  
Author(s):  
Masamitsu Sugie ◽  
Kazumasa Harada ◽  
Tetsuya Takahashi ◽  
Marina Nara ◽  
Joji Ishikawa ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Cardiac Function ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Community Dwelling Older Adults

scholarly journals Skeletal Muscle Mass and Higher-Level Functional Capacity in Female Community-Dwelling Older Adults

2021 ◽  
Vol 18 (13) ◽  
pp. 6692
Author(s):  
Shuichi Wakayama ◽  
Yoshihiko Fujita ◽  
Keisuke Fujii ◽  
Takeshi Sasaki ◽  
Hiroshi Yuine ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Functional Capacity ◽  
Skeletal Muscle Mass ◽  
Handgrip Strength ◽  
Community Dwelling ◽  
Term Care ◽  
Female Community ◽  
Community Dwelling Older Adults

Purpose: In this study, our purpose was to examine the relationship between skeletal muscle mass and higher-level functional capacity in female community-dwelling older adults. Participant(s) and Methods: In this cross-sectional study, we targeted 55 female community-dwelling older adults aged 65 years and above participating in long-term care prevention classes in Ibaraki Prefecture between 2018 and 2020. We excluded individuals with cognitive impairment and those judged as having sarcopenia. The variables of interest included age, height, weight, body mass index, skeletal muscle mass index (SMI), handgrip strength, step count, and family structure. We calculated the SMI by dividing the extremities’ total lean mass by the square of the height (in m), while the number of steps was calculated using the three-axis accelerometer Actigraph GT3X®. We measured skeletal muscle mass via bioelectrical impedance analysis using the InBody270 body composition analyzer and muscular strength as grip strength. Results: We observed significant relationships between skeletal muscle mass and Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) (β = 0.336, p < 0.01) and handgrip strength (β = 0.230). Conclusion: In this study, a relationship between skeletal muscle mass and higher-level functional capacity was demonstrated among elderly female community residents.

scholarly journals PREDICTORS OF DECREASED SKELETAL MUSCLE MASS IN COMMUNITY-DWELLING OLDER ADULTS

2015 ◽  
pp. 1-7
Author(s):  
N. Shiraishi ◽  
Y. Suzuki ◽  
T. Hirose ◽  
S. Jeong ◽  
T. Shimada ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Short Form ◽  
Mini Nutritional Assessment ◽  
Community Dwelling ◽  
Muscle Quality ◽  
Cart Analysis ◽  
Community Dwelling Older Adults

Objective: To date, the actual prevalence of Skeletal muscle mass (SMM) loss by rigorous definition and its related factors have not been sufficiently surveyed in the community. We therefore examined the factors related to the reductions of skeletal muscle mass (SMM) in older adults. Design: Case-control study. Subjects: One hundred twenty four community-dwelling older adults aged ≥65 years participated. Measurements: Reductions of SMM were assessed by measuring difference between SMM at baseline and SMM 1 year later, by which participants were divided into three groups. Variables of the first tertile group, who had the greatest decrease in SMM, were compared with those of the second/third tertile groups. Variables included hight, weight, body mass index (BMI), maximal knee extension strength, grip strength, lower and upper muscle quality (UMQ), 5-m walking time (WT), timed up and go (TUG), food frequency questionnaire, mini nutritional assessment short form (MNA-SF), basic health checklist. A logistic regression analysis and classification and regression trees (CART) were used for multivariate analysis in order to extract variables that predicted reductions of SMM. Results: Significant differences were observed for age, SMM, UMQ, TUG, and WT between the first tertile and the second/third tertile groups, The CART analysis indicated that vitamin D intake UMQ and 5-m WT predicted significant decrease in SMM. Conclusion: The present study suggested a possibility that future reductions of SMM could be predicted by simple indices that may contribute to early detection of individuals at risk of developing sarcopenia in old age.

scholarly journals Arterial stiffness is associated with low skeletal muscle mass in Japanese community-dwelling older adults

2014 ◽  
Vol 14 ◽  
pp. 109-114 ◽  
Author(s):  
Ricardo Aurélio Carvalho Sampaio ◽  
Priscila Yukari Sewo Sampaio ◽  
Minoru Yamada ◽  
Taiki Yukutake ◽  
Marco Carlos Uchida ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Arterial Stiffness ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Community Dwelling Older Adults
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