Effects of two physical exercise protocols on physical performance related to falls in the oldest old: A randomized controlled trial

2015 ◽  
Vol 16 (4) ◽  
pp. 492-499 ◽  
Author(s):  
Juliana Hotta Ansai ◽  
Thais Rabiatt Aurichio ◽  
Raquel Gonçalves ◽  
José Rubens Rebelatto
Keyword(s):  
Randomized Controlled Trial ◽  
Physical Exercise ◽  
Physical Performance ◽  
Controlled Trial ◽  
Oldest Old ◽  
Randomized Controlled

scholarly journals Baseline Characteristics of Participants in a Randomized Controlled Trial of Metformin for Frailty Prevention

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 130-131
Author(s):  
Tiffany Cortes ◽  
Nicolas Musi ◽  
Chen-pin Wang ◽  
Joel Michalek ◽  
Sara Espinoza
Keyword(s):  
Randomized Controlled Trial ◽  
Glucose Tolerance ◽  
Physical Performance ◽  
Controlled Trial ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Double Blind ◽  
Randomized Controlled ◽  
Insulin Clamp ◽  
And Function

Abstract We are conducting a double-blind, randomized controlled trial of metformin for frailty prevention. Participants are adults aged 65+ years with pre-diabetes assessed by 2-hour oral glucose tolerance test (OGTT). Those who are frail (Fried criteria) are excluded. Participants are randomized to metformin (maximum dose of 2,000 mg/day) vs. placebo and followed for 2 years. The primary outcome is frailty (category and score); secondary outcomes are physical performance and function (short physical performance battery, 6-minute walk, lower extremity strength), systemic and skeletal muscle tissue inflammation, muscle insulin signaling, insulin sensitivity (insulin clamp), glucose tolerance (OGTT), and body composition (dual-energy x-ray absorptiometry). Safety assessments occur every 3 months; frailty, systemic inflammation, and OGTT are assessed at baseline and every 6 months, and insulin clamp with muscle biopsies are assessed at baseline and every 12 months. To date, 85 subjects have been randomized; 120 completers are planned. Mean age is 72.8 ± 5.7 years, 55.3% are male, and 43.5% were Hispanic. Mean BMI is 30.2±5.8 kg/m2, waist circumference is 104.4 ±15.5 cm, fasting glucose is 102.3 ± 10.0 mg/dL, Hemoglobin A1c is 5.8 ±0.3, and glucose at 2 hours during OGTT is 167.3 ± 17.8 mg/dL. Metformin is being examined in this study as a potential therapeutic agent to prevent frailty in older adults with pre-diabetes. Findings from this trial may have future implications for the screening and potential treatment of pre-diabetes in older patients with metformin for the prevention of frailty.

scholarly journals Assisted Physical Exercise for Improving Bone Strength in Preterm Infants Less than 35 Weeks Gestation: A Randomized Controlled Trial

2017 ◽  
Vol 55 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Subhash Chandra Shaw ◽  
Mari Jeeva Sankar ◽  
Anu Thukral ◽  
Chandra Kumar Natarajan ◽  
Ashok K. Deorari ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Physical Exercise ◽  
Bone Strength ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Physical exercise as a supplement to outpatient treatment of alcohol use disorders – a randomized controlled trial

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Sengül Sari ◽  
Randi Bilberg ◽  
Kurt Jensen ◽  
Anette Søgaard-Nielsen ◽  
Bent Nielsen ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Alcohol Use ◽  
Physical Exercise ◽  
Outpatient Treatment ◽  
Controlled Trial ◽  
Alcohol Use Disorders ◽  
Randomized Controlled
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