Age-related changes of leptin and leptin receptor variants in healthy elderly and long-lived adults

2014 ◽  
Vol 15 (3) ◽  
pp. 365-371 ◽  
Author(s):  
Malgorzata Roszkowska-Gancarz ◽  
Marta Jonas ◽  
Magdalena Owczarz ◽  
Alina Kurylowicz ◽  
Jacek Polosak ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Healthy Elderly ◽  
Age Related ◽  
Age Related Changes

scholarly journals Longitudinal Age-Related Changes in 24-Hour Total Heart Beats and Premature Beats and Their Relationship in Healthy Elderly Subjects

2006 ◽  
Vol 47 (4) ◽  
pp. 549-563 ◽  
Author(s):  
Hirofumi Tasaki ◽  
Takumi Serita ◽  
Chiaki Ueyama ◽  
Kouei Kitano ◽  
Shinji Seto ◽  
...  
Keyword(s):  
Elderly Subjects ◽  
Healthy Elderly ◽  
Age Related ◽  
Premature Beats ◽  
Age Related Changes ◽  
Healthy Elderly Subjects

scholarly journals Age-Related Changes in Resting-State Networks of A Large Sample Size of Healthy Elderly

2015 ◽  
Vol 21 (10) ◽  
pp. 817-825 ◽  
Author(s):  
Chun-Chao Huang ◽  
Wen-Jin Hsieh ◽  
Pei-Lin Lee ◽  
Li-Ning Peng ◽  
Li-Kuo Liu ◽  
...  
Keyword(s):  
Sample Size ◽  
Resting State ◽  
Large Sample Size ◽  
Resting State Networks ◽  
Large Sample ◽  
Healthy Elderly ◽  
Age Related ◽  
Age Related Changes

scholarly journals Developmental Changes of Leptin Receptors in Cerebral Microvessels: Unexpected Relation to Leptin Transport

Endocrinology ◽  
2007 ◽  
Vol 149 (3) ◽  
pp. 877-885 ◽  
Author(s):  
Weihong Pan ◽  
Hung Hsuchou ◽  
Hong Tu ◽  
Abba J. Kastin
Keyword(s):  
Leptin Receptor ◽  
Brain Perfusion ◽  
Developmental Changes ◽  
Pcr Analysis ◽  
Receptor Subtypes ◽  
Cerebral Microvessels ◽  
Leptin Receptors ◽  
Age Related ◽  
Significant Difference ◽  
Age Related Changes

The adipokine leptin participates not only in the regulation of feeding and obesity in adults but also in neonatal development. It crosses the blood-brain barrier (BBB) by receptor-mediated transport. Leptin concentrations in blood differ between neonates and adults. We determined the developmental changes of leptin receptor subtypes in the cerebral microvessels composing the BBB and examined their expected correlation with leptin transport across the BBB. Total RNA was extracted from enriched cerebral microvessels of mice 1, 7, 14, and 60 d of age for real-time RT-PCR analysis of leptin receptor subtypes. In cerebral microvessels from neonates, ObRa, ObRb, ObRc, and ObRe mRNA were all higher than in adults, but ObRd was not detectable. Hypothalamus showed similar age-related changes except for ObRb, which was higher in adults. The homologous receptor gp130 did not show significant age-related changes in either region. Despite the increase of leptin receptors, leptin permeation across the BBB after iv injection was less in the neonates. In situ brain perfusion with blood-free buffer showed no significant difference in the brain uptake of leptin between neonates and adults, indicating an antagonistic role of leptin-binding proteins in the circulation, especially the soluble receptor ObRe. The results are consistent with our previous finding that ObRe antagonizes leptin endocytosis in cultured endothelia and transport from blood to brain in mice. Overall, the developmental changes observed for leptin receptors unexpectedly failed to correlate with the entry of leptin into brain, and this may indicate different functions of the receptors in neonates and adults.

scholarly journals Age-Related Changes in Postural Responses to Backward Platform Translation

2012 ◽  
pp. 331-335 ◽  
Author(s):  
Z. HALICKÁ ◽  
J. LOBOTKOVÁ ◽  
D. BZDÚŠKOVÁ ◽  
F. HLAVAČKA
Keyword(s):  
Balance Control ◽  
Tibialis Anterior Muscle ◽  
Emg Activity ◽  
Eyes Closed ◽  
Healthy Elderly ◽  
Age Related ◽  
Postural Responses ◽  
Co Activation ◽  
Platform Translation ◽  
Age Related Changes

The aim of the study was to investigate age-related changes in postural responses to platform translation with 3 various velocities. We focused on the influence of linear velocity using the smoothed profile of platform acceleration (till 100 cm.s−2). Eleven healthy young (20-31 years) and eleven healthy elderly (65-76 years) subjects were examined. The subjects stood on the force platform with their eyes closed. Each trial (lasting for 8 sec) with different velocity (10, 15, 20 cm.s−1) of 20 cm backward platform translation was repeated 4 times. We have recorded displacements of the centre of pressure (CoP) and the EMG activity of gastrocnemius muscle (GS) and tibialis anterior muscle (TA). The results showed increased maximal values of CoP responses to the platform translation. There was also observed a scaling delay of CoP responses to platform translation with different velocities in elderly. The EMG activity of GS muscle during backward platform translation was of about similar shape in both groups during the slowest platform velocity, but it increased depending on rising velocity. EMG activity of TA was not related to the platform velocity. Early parts of postural responses showed significant co-activation of TA and GS muscles of elderly. It is likely that elderly increased body stiffening in order to help their further balance control.

scholarly journals Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study

2011 ◽  
Vol 4 (1) ◽  
Author(s):  
Soichiro Kitamura ◽  
Masayuki Morikawa ◽  
Kuniaki Kiuchi ◽  
Toshiaki Taoka ◽  
Masami Fukusumi ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Healthy Elderly ◽  
Age Related ◽  
Age Related Changes

Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts

1998 ◽  
Vol 62 (2) ◽  
pp. 115-122 ◽  
Author(s):  
G. De BENEDICTIS ◽  
L. CAROTENUTO ◽  
G. CARRIERI ◽  
M. De LUCA ◽  
E. FALCONE ◽  
...  
Keyword(s):  
Age Related ◽  
Age Related Changes
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