Thermal limits in the face of infectious disease: how important are pathogens?

2021 ◽  
Author(s):  
Tobias E. Hector ◽  
Carla M. Sgrò ◽  
Matthew D. Hall
Author(s):  
Ahmad Mujahed Abdulqader Mousa ◽  
Zadorozhna Anna ◽  
Dieieva Julia ◽  
Tereshchenko Zhanna ◽  
Konovalov Serhii

Purpose of Review: Chronic rhinosinusitis (CRS) is denoted as the symptomatic inflammations of sin nasal mucosa persists for ≥12 weeks. The purpose of this study was to review the recent literatures for digging out a clear concept on the clinical presentations of patients with chronic rhinosinusitis and assess the potentialities of the features. Recent Findings: According to the findings, descriptions and discussions of several recent studies it was observed that, a package of clinical features and presentations are associated with chronic rhinosinusitis. Some are major and some are minor potentials. The frequencies and severities of symptoms and features are directly dependent on the duration of that disease. Summary: Basically, rhinosinusitis or CRS is an inflammatory and infectious disease which affects the nasal cavities as well as the paranasal sinuses of patients. Rhinosinusitis with polyps is more common in male than that in female. There are many possible clinical features of CRS. But as per the frequencies, duration and effects nasal congestion, nasal discharge (Anterior/posterior nasal drip), pain/pressure on the face, impaired ability to smell (Hyposmia/anosmia), dizziness, fever and cough are the most common clinical features of chronic rhinosinusitis.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 988-989
Author(s):  
Leena Almasri ◽  
Barbara Carlson ◽  
Julie Myers ◽  
Rebecca Koszalinski ◽  
Melissa Franklin ◽  
...  

Abstract Recruiting nursing home residents as participants in research is challenging. In early 2021, Covid-19 cases rose rapidly in nursing homes, prompting the rapid deployment of infectious disease protocols and ultimately, facility lockdowns to control the spread of the virus. By September, 2020, many research projects were delayed or cancelled, and future research was jeopardized. During this period, as well as prior to and after the administration of the COVID vaccine, we enrolled residents in a complex protocol involving administration of two Shingles vaccines (0- and 90 days) and three separate blood samples. Here, we present the strategies we used to recruit 216 residents, from 23 homes, over a 9-month period. We faced many challenges. Our research staff faced weekly COVID-19 antigen tests prior to entering the facility, adhering to strict protocols on travel, as well as packaging of materials that entered and left the facility. N95 masks and face shields further made it difficult to communicate with residents. For homes, COVID protocols required residents to be transported to specified areas to meet with research staff. Daily monitoring of COVID and Shingrix vaccine symptoms became part of daily care. To minimize resident harm and interruption of workflow in nursing homes, we utilized principles of stakeholder engagement, healthcare leadership, infectious disease/immunology, and staff (research and nursing homes) empowerment. In the face of crisis, like the COVID-19 pandemic, we have gained the trust and commitment of these facilities; thus, establishing a sustainable partnership that is prepared for what comes next.


2019 ◽  
Vol 374 (1776) ◽  
pp. 20180280 ◽  
Author(s):  
Laurie Baker ◽  
Jason Matthiopoulos ◽  
Thomas Müller ◽  
Conrad Freuling ◽  
Katie Hampson

Understanding how the spatial deployment of interventions affects elimination time horizons and potential for disease re-emergence has broad application to control programmes targeting human, animal and plant pathogens. We previously developed an epidemiological model that captures the main features of rabies spread and the impacts of vaccination based on detailed records of fox rabies in eastern Germany during the implementation of an oral rabies vaccination (ORV) programme. Here, we use simulations from this fitted model to determine the best vaccination strategy, in terms of spatial placement and timing of ORV efforts, for three epidemiological scenarios representative of current situations in Europe. We found that consecutive and comprehensive twice-yearly vaccinations across all regions rapidly controlled and eliminated rabies and that the autumn campaigns had the greater impact on increasing the probability of elimination. This appears to result from the need to maintain sufficient herd immunity in the face of large birth pulses, as autumn vaccinations reach susceptible juveniles and therefore a larger proportion of the population than spring vaccinations. Incomplete vaccination compromised time to elimination requiring the same or more vaccination effort to meet similar timelines. Our results have important practical implications that could inform policies for rabies containment and elimination in Europe and elsewhere. This article is part of the theme issue ‘Modelling infectious disease outbreaks in humans, animals and plants: epidemic forecasting and control’. This theme issue is linked with the earlier issue ‘Modelling infectious disease outbreaks in humans, animals and plants: approaches and important themes’.


1924 ◽  
Vol 70 (290) ◽  
pp. 432-433
Author(s):  
S. Grossman

Actinomycosis is a rare local specific infectious disease, due to the actinomyces, or ray fungus. The actinomyces is a streptothrix, and grows in colonies which are just visible to the naked eye, and these colonies, on microscopical examination, are found to consist of three elements–filaments, cocci, and clubs. In young cultures they stain uniformly, and are Gram-positive. The streptothrix gives rise to a hard, slow-growing tumour, going on to ulceration, with a thin sero-purulent discharge, containing yellow granules in which the ray fungus can be found. The organism is found growing on cereals, especially barley, and commonly infects cattle. Man is infected in the same way, and the disease is generally met with in farmers, corn-eaters, graziers, etc., especially if the patient has the habit of chewing straw, the infection most commonly occurring in the tongue, jaw, and spreading thence to the skin of the face and neck.


2021 ◽  
Vol 2 ◽  
Author(s):  
Bianca Aboubakare ◽  
James Chen ◽  
Johnah C. Galicia

In December 2019, the coronavirus disease 2019 (COVID-19) was first identified as an acute infectious disease in Wuhan, China, and subsequently led to an ongoing pandemic. At the onset of the pandemic, dental professionals were understood to face the greatest exposure risk to SARS-CoV-2 due to aerosolization of fluids from the oral cavity and respiratory airways. As a result, dental professionals, including academic institutions and their students and residents, halted much of their operations to minimize exposure risks and potentially slow the spread of infection to peers and patients alike. Currently, there is little in the literature that describes the changes that academic institutions have implemented in the face of pandemics. This study will discuss the chronology, modifications, and possible resultant outcomes of COVID-19 related events in respect to graduate endodontic programs in the United States.


2018 ◽  
Vol 14 (02) ◽  
pp. 043-051
Author(s):  
Stacie Gregory ◽  
Robert Chun ◽  
Anna Huppler ◽  
Sindhu Mohandas

AbstractPediatric deep neck space infections (DNSI) are common in children. If unrecognized, DNSIs can rapidly progress with the potential for developing serious complications. Children fair better than their adult counterparts in the face of complications such as mediastinitis, but early recognition and aggressive management is key to prevent mortality and limit morbidity. Knowledge of the anatomy related to the deep neck spaces helps in anticipating and managing the potential complications. In this article, we review the clinical presentation, complications, and management in pediatric DNSI from the point of view of the pediatric infectious disease physician and the otolaryngologist. We discuss the best management based on current available evidence and the experience of the authors.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Matthew J. Crawford ◽  
Sepehr Ramezani ◽  
Roghaie Jabbari ◽  
Pawan Pathak ◽  
Hyoung J. Cho ◽  
...  

AbstractWith the spread of COVID-19, significant emphasis has been placed on mitigation techniques such as mask wearing to slow infectious disease transmission. Widespread use of face coverings has revealed challenges such as mask contamination and waste, presenting an opportunity to improve the current technologies. In response, we have developed the Auto-sanitizing Retractable Mask Optimized for Reusability (ARMOR). ARMOR is a novel, reusable face covering that can be quickly disinfected using an array of ultraviolet C lamps contained within a wearable case. A nanomembrane UVC sensor was used to quantify the intensity of germicidal radiation at 18 different locations on the face covering and determine the necessary exposure time to inactivate SARS-CoV-2 in addition to other viruses and bacteria. After experimentation, it was found that ARMOR successfully provided germicidal radiation to all areas of the mask and will inactivate SARS-CoV-2 in approximately 180 s, H1N1 Influenza in 130 s, and Mycobacterium tuberculosis in 113 s, proving that this design is effective at eliminating a variety of pathogens and can serve as an alternative to traditional waste-producing disposable face masks. The accessibility, ease of use, and speed of sanitization supports the wide application of ARMOR in both clinical and public settings.


2021 ◽  
Author(s):  
Matthew J. Crawford ◽  
Sepehr Ramezani ◽  
Roghaie Jabbari ◽  
Pawan Pathak ◽  
Hyong Jin Cho ◽  
...  

Abstract With the spread of COVID-19, significant emphasis has been placed on mitigation techniques such as mask wearing to slow infectious disease transmission. Widespread use of face coverings has revealed challenges such as mask contamination and waste, presenting an opportunity to improve the current technologies. In response, we have developed the Auto-sanitizing Retractable Mask Optimized for Reusability (ARMOR). ARMOR is a novel, reusable face covering that can be quickly disinfected using an array of ultraviolet C lamps contained within a wearable case. A nanomembrane UVC sensor was used to quantify the intensity of germicidal radiation at 18 different locations on the face covering and determine the necessary exposure time to inactivate SARS-CoV-2 in addition to other viruses and bacteria. After experimentation, it was found that ARMOR successfully provided germicidal radiation to all areas of the mask and will inactivate SARS-CoV-2 in approximately 180 seconds, H1N1 Influenza in 130 seconds, and Mycobacterium tuberculosis in 113 seconds, proving that this design is effective at eliminating a variety of pathogens and can serve as an alternative to traditional waste-producing disposable face masks. The accessibility, ease of use, and speed of sanitization supports the wide application of ARMOR in both clinical and public settings.


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