scholarly journals Complex patterns of dopamine‐related gene expression in the ventral tegmental area of male zebra finches relate to dyadic interactions with long‐term female partners

2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Sarah J. Alger ◽  
Cynthia A. Kelm‐Nelson ◽  
Sharon A. Stevenson ◽  
Charity Juang ◽  
Stephen C. Gammie ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Zebra Finches ◽  
Dyadic Interactions ◽  
Related Gene ◽  
Female Partners ◽  
Complex Patterns ◽  
Ventral Tegmental

scholarly journals Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area

2021 ◽  
Author(s):  
Rianne R. Campbell ◽  
Siwei Chen ◽  
Joy H. Beardwood ◽  
Alberto J. López ◽  
Lilyana V. Pham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Home Cage ◽  
Expression Patterns ◽  
Energy Regulation ◽  
Biological Processes ◽  
Cocaine Exposure ◽  
Self Administration ◽  
Drug Reinforcement ◽  
Ventral Tegmental

AbstractDuring the initial stages of drug use, cocaine-induced neuroadaptations within the ventral tegmental area (VTA) are critical for drug-associated cue learning and drug reinforcement processes. These neuroadaptations occur, in part, from alterations to the transcriptome. Although cocaine-induced transcriptional mechanisms within the VTA have been examined, various regimens and paradigms have been employed to examine candidate target genes. In order to identify key genes and biological processes regulating cocaine-induced processes, we employed genome-wide RNA-sequencing to analyze transcriptional profiles within the VTA from male mice that underwent one of four commonly used paradigms: acute home cage injections of cocaine, chronic home cage injections of cocaine, cocaine-conditioning, or intravenous-self administration of cocaine. We found that cocaine alters distinct sets of VTA genes within each exposure paradigm. Using behavioral measures from cocaine self-administering mice, we also found several genes whose expression patterns corelate with cocaine intake. In addition to overall gene expression levels, we identified several predicted upstream regulators of cocaine-induced transcription shared across all paradigms. Although distinct gene sets were altered across cocaine exposure paradigms, we found, from Gene Ontology (GO) term analysis, that biological processes important for energy regulation and synaptic plasticity were affected across all cocaine paradigms. Coexpression analysis also identified gene networks that are altered by cocaine. These data indicate that cocaine alters networks enriched with glial cell markers of the VTA that are involved in gene regulation and synaptic processes. Our analyses demonstrate that transcriptional changes within the VTA depend on the route, dose and context of cocaine exposure, and highlight several biological processes affected by cocaine. Overall, these findings provide a unique resource of gene expression data for future studies examining novel cocaine gene targets that regulate drug-associated behaviors.

Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area

2007 ◽  
Vol 26 (3) ◽  
pp. 749-756 ◽  
Author(s):  
Federica Sarti ◽  
Stephanie L. Borgland ◽  
Viktor N. Kharazia ◽  
Antonello Bonci
Keyword(s):  
Ventral Tegmental Area ◽  
Long Term Potentiation ◽  
Spine Density ◽  
Cocaine Exposure ◽  
Term Potentiation ◽  
Ventral Tegmental

Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats

2014 ◽  
Vol 20 (2) ◽  
pp. 336-344 ◽  
Author(s):  
Eduardo Karahanian ◽  
Mario Rivera-Meza ◽  
Lutske Tampier ◽  
María Elena Quintanilla ◽  
Mario Herrera-Marschitz ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Aldehyde Dehydrogenase ◽  
Lentiviral Vector ◽  
Ethanol Intake ◽  
Aldehyde Dehydrogenase 2 ◽  
Ventral Tegmental

scholarly journals Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats

Alcohol ◽  
2013 ◽  
Vol 47 (5) ◽  
pp. 367-380 ◽  
Author(s):  
William J. McBride ◽  
Mark W. Kimpel ◽  
Jeanette N. McClintick ◽  
Zheng-Ming Ding ◽  
Sheketha R. Hauser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ventral Tegmental Area ◽  
Alcohol Drinking ◽  
Ventral Tegmental
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