scholarly journals Genome‐wide association studies of alcohol dependence, DSM‐IV criterion count and individual criteria

2019 ◽  
Author(s):  
Dongbing Lai ◽  
Leah Wetherill ◽  
Sarah Bertelsen ◽  
Caitlin E. Carey ◽  
Chella Kamarajan ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Dsm Iv

scholarly journals Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data

2018 ◽  
Author(s):  
Kristin M. Mignogna ◽  
Silviu A. Bacanu ◽  
Brien P. Riley ◽  
Aaron R. Wolen ◽  
Michael F. Miles
Keyword(s):  
Gene Expression ◽  
Alcohol Dependence ◽  
Mouse Brain ◽  
Gene Networks ◽  
Association Studies ◽  
Complex Trait ◽  
Genome Wide Association ◽  
Model Organisms ◽  
Genome Wide Association Studies ◽  
Genome Wide

AbstractGenome-wide association studies on alcohol dependence, by themselves, have yet to account for the estimated heritability of the disorder and provide incomplete mechanistic understanding of this complex trait. Integrating brain ethanol-responsive gene expression networks from model organisms with human genetic data on alcohol dependence could aid in identifying dependence-associated genes and functional networks in which they are involved. This study used a modification of the Edge-Weighted Dense Module Searching for genome-wide association studies (EW-dmGWAS) approach to co-analyze whole-genome gene expression data from ethanol-exposed mouse brain tissue, human protein-protein interaction databases and alcohol dependence-related genome-wide association studies. Results revealed novel ethanol-regulated and alcohol dependence-associated gene networks in prefrontal cortex, nucleus accumbens, and ventral tegmental area. Three of these networks were overrepresented with genome-wide association signals from an independent dataset. These networks were significantly overrepresented for gene ontology categories involving several mechanisms, including actin filament-based activity, transcript regulation, Wnt and Syndecan-mediated signaling, and ubiquitination. Together, these studies provide novel insight for brain mechanisms contributing to alcohol dependence.

A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence

2011 ◽  
Vol 45 (11) ◽  
pp. 1419-1425 ◽  
Author(s):  
Ke-Sheng Wang ◽  
Xuefeng Liu ◽  
Qunyuan Zhang ◽  
Yue Pan ◽  
Nagesh Aragam ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Association Studies ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals The influence of regression models on genome-wide association studies of alcohol dependence

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Wenqianglong Li ◽  
Johan Hilge Thygesen ◽  
Niamh Louise O’Brien ◽  
Mathis Heydtmann ◽  
Iain Smith ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Regression Models ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals Replication of Genome Wide Association Studies of Alcohol Dependence: Support for Association with Variation in ADH1C

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58798 ◽  
Author(s):  
Joanna M. Biernacka ◽  
Jennifer R. Geske ◽  
Terry D. Schneekloth ◽  
Mark A. Frye ◽  
Julie M. Cunningham ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence

2013 ◽  
Vol 19 (4) ◽  
pp. 708-721 ◽  
Author(s):  
Jia Yan ◽  
Fazil Aliev ◽  
Bradley T. Webb ◽  
Kenneth S. Kendler ◽  
Vernell S. Williamson ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Candidate Gene ◽  
Risk Prediction ◽  
Genetic Information ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide
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