scholarly journals Visual motion and rapid auditory processing are solid endophenotypes of developmental dyslexia

2017 ◽  
Vol 17 (1) ◽  
pp. 70-81 ◽  
Author(s):  
S. Mascheretti ◽  
S. Gori ◽  
V. Trezzi ◽  
M. Ruffino ◽  
A. Facoetti ◽  
...  
Keyword(s):  
Developmental Dyslexia ◽  
Auditory Processing ◽  
Visual Motion ◽  
Rapid Auditory Processing

scholarly journals The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia

2020 ◽  
Vol 10 (12) ◽  
pp. 993
Author(s):  
Sara Mascheretti ◽  
Valentina Riva ◽  
Bei Feng ◽  
Vittoria Trezzi ◽  
Chiara Andreola ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Auditory Processing ◽  
Visual Motion ◽  
Multisensory Processing ◽  
Molecular Genetic ◽  
Rapid Automatized Naming ◽  
Motion Processing ◽  
Visual Motion Processing ◽  
Molecular Genetic Data ◽  
Rapid Auditory Processing

Although substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD). Reading-related endophenotypes (EPs) have been established. Until now it was unknown whether they mediated the pathway from gene to reading (dis)ability. Thus, in a sample of 223 siblings from nuclear families with DD and 79 unrelated typical readers, we tested four EPs (i.e., rapid auditory processing, rapid automatized naming, multisensory nonspatial attention and visual motion processing) and 20 markers spanning five DD-candidate genes (i.e., DYX1C1, DCDC2, KIAA0319, ROBO1 and GRIN2B) using a multiple-predictor/multiple-mediator framework. Our results show that rapid auditory and visual motion processing are mediators in the pathway from ROBO1-rs9853895 to reading. Specifically, the T/T genotype group predicts impairments in rapid auditory and visual motion processing which, in turn, predict poorer reading skills. Our results suggest that ROBO1 is related to reading via multisensory temporal processing. These findings support the use of EPs as an effective approach to disentangling the complex pathways between candidate genes and behavior.

scholarly journals Rapid auditory processing and learning deficits in rats with P1 versus P7 neonatal hypoxic-ischemic injury

2006 ◽  
Vol 172 (1) ◽  
pp. 114-121 ◽  
Author(s):  
Melissa M. McClure ◽  
Steven W. Threlkeld ◽  
Glenn D. Rosen ◽  
R. Holly Fitch
Keyword(s):  
Auditory Processing ◽  
Ischemic Injury ◽  
Learning Deficits ◽  
Rapid Auditory Processing ◽  
Hypoxic Ischemic Injury

Sex differences in rapid auditory processing deficits in ectopic BXSB/MpJ mice

Neuroreport ◽  
2002 ◽  
Vol 13 (17) ◽  
pp. 2277-2280 ◽  
Author(s):  
Ann M. Peiffer ◽  
Glenn D. Rosen ◽  
R. Holly Fitch
Keyword(s):  
Sex Differences ◽  
Auditory Processing ◽  
Rapid Auditory Processing ◽  
Processing Deficits

Impaired Processing of Complex Auditory Stimuli in Rats with Induced Cerebrocortical Microgyria: An Animal Model of Developmental Language Disabilities

2000 ◽  
Vol 12 (5) ◽  
pp. 828-839 ◽  
Author(s):  
Matthew G. Clark ◽  
Glenn D. Rosen ◽  
Paula Tallal ◽  
R. Holly Fitch
Keyword(s):  
Specific Language Impairment ◽  
Auditory Processing ◽  
Total Duration ◽  
Initial Study ◽  
Male Rats ◽  
Auditory Stimuli ◽  
Oddball Paradigm ◽  
Language Disabilities ◽  
Rapid Auditory Processing ◽  
Processing Deficits

Individuals with developmental language disabilities, including developmental dyslexia and specific language impairment (SLI), exhibit impairments in processing rapidly presented auditory stimuli. It has been hypothesized that these deficits are associated with concurrent deficits in speech perception and, in turn, impaired language development. Additionally, postmortem analyses of human dyslexic brains have revealed the presence of focal neocortical malformations such as cerebrocortical microgyria. In an initial study bridging these research domains, we found that male rats with induced microgyria were impaired in discriminating rapidly presented auditory stimuli. In order to further assess this anatomical-behavioral association, we designed two experiments using auditory-reflex modification. These studies were intended to assess whether auditory processing deficits in microgyric male rats would be seen in threshold detection of a silent gap in white noise, and in oddball detection of a two-tone stimulus of variable duration. Results showed no differences between sham and microgyric subjects on gap detection, but did show that microgyric subjects were impaired in the discrimination of two-tone stimuli presented in an oddball paradigm. This impairment was evident for stimuli with total duration of 64 msec or less, while both groups were able to discriminate stimuli with duration of 89 msec or greater. The current results further support the relationship between malformations of the cerebral cortex and deficits in rapid auditory processing. They also suggest that the parameters characterizing rapid auditory processing deficits for a specific task may be influenced by stimulus features and/or cognitive demand of that particular task.

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