Overexpression of the NR2A subunit in the forebrain impairs long-term social recognition and non-social olfactory memory

2014 ◽  
Vol 13 (4) ◽  
pp. 376-384 ◽  
Author(s):  
S. A. Jacobs ◽  
J. Z. Tsien
Keyword(s):  
Social Recognition ◽  
Olfactory Memory ◽  
Nr2a Subunit

scholarly journals Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 555
Author(s):  
Barbara Rani ◽  
Bruna Silva-Marques ◽  
Rob Leurs ◽  
Maria Beatrice Passani ◽  
Patrizio Blandina ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Histamine Release ◽  
Histidine Decarboxylase ◽  
Acetylcholinesterase Inhibitor ◽  
Social Recognition ◽  
Amnesic Effect ◽  
Brain Histamine ◽  
Monogamous Species ◽  
Social Recognition Memory

The ability of recognizing familiar conspecifics is essential for many forms of social interaction including reproduction, establishment of dominance hierarchies, and pair bond formation in monogamous species. Many hormones and neurotransmitters have been suggested to play key roles in social discrimination. Here we demonstrate that disruption or potentiation of histaminergic neurotransmission differentially affects short (STM) and long-term (LTM) social recognition memory. Impairments of LTM, but not STM, were observed in histamine-deprived animals, either chronically (Hdc−/− mice lacking the histamine-synthesizing enzyme histidine decarboxylase) or acutely (mice treated with the HDC irreversible inhibitor α-fluoromethylhistidine). On the contrary, restriction of histamine release induced by stimulation of the H3R agonist (VUF16839) impaired both STM and LTM. H3R agonism-induced amnesic effect was prevented by pre-treatment with donepezil, an acetylcholinesterase inhibitor. The blockade of the H3R with ciproxifan, which in turn augmented histamine release, resulted in a procognitive effect. In keeping with this hypothesis, the procognitive effect of ciproxifan was absent in both Hdc−/− and αFMH-treated mice. Our results suggest that brain histamine is essential for the consolidation of LTM but not STM in the social recognition test. STM impairments observed after H3R stimulation are probably related to their function as heteroreceptors on cholinergic neurons.

Odour Memory and Odour Hedonics in Children

Perception ◽  
1989 ◽  
Vol 18 (3) ◽  
pp. 391-396 ◽  
Author(s):  
Loredana Hvastja ◽  
Lucia Zanuttini
Keyword(s):  
Recognition Test ◽  
Age Groups ◽  
Stimulus Presentation ◽  
Emotional Memory ◽  
Point Scale ◽  
Olfactory Memory ◽  
Rapid Decay ◽  
Memory Decay ◽  
Olfactory Stimuli

The characteristics of olfactory memory during development were investigated and the hypothesis that the pleasantness of smells may be affected by previous associations with pleasant or unpleasant objects or events was tested. This type of emotional memory was compared in the immediate and long-term recognition of olfactory stimuli. Children from three different age groups (mean ages: 6 years 6 months; 8 years 9 months; and 10 years 5 months) were subdivided into two groups. One group was presented with six different odours, each with a slide depicting a pleasant picture. The other group was presented with the odours accompanied by unpleasant pictures. Immediately after stimulus presentation the subjects underwent a recognition test. One month later the subjects underwent a second recognition test, at the end of which they were required to give an evaluation of the pleasantness of each odour on a nine-point scale. At no age level did the pictures matched to the odours affect the recognition score. Olfactory memory varied with age, chiefly because memory decay increased with age, perhaps because of greater proactive interference. With increasing age more rapid decay was set against better immediate recognition. The hypothesis that the hedonic characteristics of odours are partially learned and are affected by events experienced in other modalities was supported.

scholarly journals Elongator complex is required for long-term olfactory memory formation in Drosophila

2018 ◽  
Vol 25 (4) ◽  
pp. 183-196 ◽  
Author(s):  
Dinghui Yu ◽  
Ying Tan ◽  
Molee Chakraborty ◽  
Seth Tomchik ◽  
Ronald L. Davis
Keyword(s):  
Memory Formation ◽  
Olfactory Memory ◽  
Elongator Complex

5-HT4 receptors: long-term blockade of K+ channels and effects on olfactory memory

1998 ◽  
Vol 321 (2-3) ◽  
pp. 217-221 ◽  
Author(s):  
Joël Bockaert ◽  
Hervé Ansanay ◽  
Sandrine Letty ◽  
Évelyne Marchetti-Gauthier ◽  
François Roman ◽  
...  
Keyword(s):  
Olfactory Memory ◽  
K Channels

scholarly journals Social isolation impacts late-life socio-cognitive decline in APP/PS1 mice

2019 ◽  
Author(s):  
Eva Rens ◽  
Rudi D’Hooge ◽  
Ann Van der Jeugd
Keyword(s):  
Social Isolation ◽  
Short Term Memory ◽  
Social Recognition ◽  
Long Term Memory ◽  
Dependent Manner ◽  
Term Memory ◽  
Y Maze ◽  
The Social ◽  
Socially Isolated

AbstractIn this study the effects of social isolation (SI) were investigated in APP/PS1 mice. It was found that SI during adolescence has an impact on anxiogenic behaviour, such that isolated animals tend to explore a threatening environment less than non-isolated animals as assessed with the EPM test, and that this holds for both AD and non-AD mice. While no evidence was found for any differences in short-term memory as assessed by the Y-maze, long-term memory seemed to be affected in a context-dependent manner. Object memory as assessed with the NOR test was affected in APP/PS1 mice compared to WT mice, but this deficit was not induced or influenced by SI. When it comes to social recognition memory however, we found that SI exacerbated the social memory deficit in AD mice, and even induced a deficit in WTs. Associative fear memory as assessed with the PA test suggested that WTs perform better when group housed, and APP/PS1 mice better when socially isolated. The link between isolation and AD, or cognition in general, may be more complex than initially thought. The effect of isolation may not be the same for AD versus non-AD subjects.

scholarly journals PROGRAMMING GENES IN BRAIN AND PROBLEM OF SOCIAL BEHAVIOR ОF MAN

2013 ◽  
Vol 12 (2) ◽  
pp. 275-283
Author(s):  
B. B. Fuks
Keyword(s):  
Human Population ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Social Recognition ◽  
Long Term Memory ◽  
Oxytocin Receptor Gene ◽  
Term Memory ◽  
And Behavior ◽  
Social Recognition Memory

Transcription factors programmed genes of brain cells. Then proteins synthesized form long term memory. Two genes of hormone vasopressin receptor – genes of altruism / selfishnessand one oxytocin receptor gene provide social recognition, memory and behavior. Human population divided into three groups: homozygous altruists, homozygous egoists and heterozygous group containing both vasopressin genes. Behavior genes programming in the last group occurs within the first two weeks of life. Negative programming of masses of people in this group could be the cause of social disasters in the twentieth century.

scholarly journals Inhibiting constitutive neurogenesis compromises long-term social recognition memory

2018 ◽  
Vol 155 ◽  
pp. 92-103 ◽  
Author(s):  
Ana Raquel Pereira-Caixeta ◽  
Leonardo O. Guarnieri ◽  
Daniel C. Medeiros ◽  
Eduardo M.A.M. Mendes ◽  
Luiz C.D. Ladeira ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Social Recognition ◽  
Social Recognition Memory
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