scholarly journals Norepinephrine transporter heterozygous knockout mice exhibit altered transport and behavior

2013 ◽  
Vol 12 (8) ◽  
pp. 749-759 ◽  
Author(s):  
H. M. Fentress ◽  
R. Klar ◽  
J. J. Krueger ◽  
T. Sabb ◽  
S. N. Redmon ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Norepinephrine Transporter ◽  
And Behavior ◽  
Altered Transport

Oxytocin and behavior: Lessons from knockout mice

2016 ◽  
Vol 77 (2) ◽  
pp. 190-201 ◽  
Author(s):  
Heather K. Caldwell ◽  
Elizabeth A. Aulino ◽  
Angela R. Freeman ◽  
Travis V. Miller ◽  
Shannah K. Witchey
Keyword(s):  
Knockout Mice ◽  
And Behavior

scholarly journals Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions

2008 ◽  
Vol 19 (5-6) ◽  
pp. 566-574 ◽  
Author(s):  
Maria T.G. Perona ◽  
Shonna Waters ◽  
Frank Scott Hall ◽  
Ichiro Sora ◽  
Klaus-Peter Lesch ◽  
...  
Keyword(s):  
Animal Models ◽  
Dopamine Transporter ◽  
Knockout Mice ◽  
Norepinephrine Transporter ◽  
Animal Models Of Depression

Sleep-wakefulness cycle and behavior in pannexin1 knockout mice

2017 ◽  
Vol 318 ◽  
pp. 24-27 ◽  
Author(s):  
V.M. Kovalzon ◽  
L.S. Moiseenko ◽  
A.V. Ambaryan ◽  
S. Kurtenbach ◽  
V.I. Shestopalov ◽  
...  
Keyword(s):  
Knockout Mice ◽  
And Behavior

scholarly journals Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice

Neuroscience ◽  
2009 ◽  
Vol 162 (4) ◽  
pp. 870-880 ◽  
Author(s):  
F.S. Hall ◽  
X.-F. Li ◽  
J. Randall-Thompson ◽  
I. Sora ◽  
D.L. Murphy ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Knockout Mice ◽  
Norepinephrine Transporter ◽  
Conditioned Locomotion

scholarly journals A ROLE FOR CORTICAL DOPAMINE IN THE PARADOXICAL CALMING EFFECTS OF PSYCHOSTIMULANTS

2021 ◽  
Author(s):  
Sharonda S Harris ◽  
Sara M Green ◽  
Mayank Kumar ◽  
Nikhil M Urs
Keyword(s):  
Knockout Mice ◽  
Ex Vivo ◽  
Integrated Approach ◽  
Primary Treatment ◽  
Monoamine Transporters ◽  
Tissue Slices ◽  
Hyperactivity Disorder ◽  
Norepinephrine Depletion ◽  
Calming Effect ◽  
And Behavior

Attention deficit hyperactivity disorder (ADHD) affects young children and manifests symptoms such as hyperactivity, impulsivity and cognitive disabilities. Psychostimulants, which are the primary treatment for ADHD, target monoamine transporters and have a paradoxical calming effect, but their mechanism of action, is unclear. Studies using the dopamine (DA) transporter (DAT) knockout mice, which have elevated striatal DA levels and are considered an animal model of ADHD, have suggested that the paradoxical calming effect of psychostimulants might be through the actions on serotonin neurotransmission. On the other hand, newer non-stimulant class of drugs such as atomoxetine and Intuniv suggest that targeting the norepinephrine (NE) system in the PFC might explain this paradoxical calming effect. We sought to decipher the mechanism of this paradoxical effect of psychostimulants through an integrated approach using ex vivo monoamine efflux experiments, monoamine transporter knockout mice, drug infusions and behavior. Our ex vivo efflux experiments reveal that NE transporter (NET) blocker desipramine elevates both norepinephrine and dopamine but not serotonin levels, in PFC tissue slices from wild-type and DAT-KO but not NET KO mice. However, serotonin (5-HT) transporter (SERT) inhibitor fluoxetine elevates only serotonin in all three genotypes. Systemic administration of both desipramine and fluoxetine but local PFC infusion of only desipramine and not fluoxetine inhibits hyperactivity in the DAT-KO mice. In contrast, pharmacological norepinephrine depletion but dopamine elevation using Nepicastat also inhibits hyperactivity in DATKO mice. Together, these data suggest that elevation of PFC dopamine and not norepinephrine or serotonin as a convergent mechanism for the paradoxical psychostimulant effects observe in ADHD therapy.  

New Lessons From Knockout Mice: The Role of Serotonin During Development and Its Possible Contribution to the Origins of Neuropsychiatric Disorders

CNS Spectrums ◽  
2003 ◽  
Vol 8 (8) ◽  
pp. 572-577 ◽  
Author(s):  
Jay A. Gingrich ◽  
Mark S. Ansorge ◽  
Robert Merker ◽  
Noelia Weisstaub ◽  
Mingming Zhou
Keyword(s):  
Neural Development ◽  
Knockout Mice ◽  
Adult Brain ◽  
The Central Nervous System ◽  
Specific Receptors ◽  
Ingestive Behaviors ◽  
And Behavior ◽  
Pharmacologic Agents ◽  
Anxiety Depression

ABSTRACTSerotonin (5-HT) modulates numerous processes in the central nervous system that are relevant to neuropsychiatric function and dysfunction. It exerts significant effects on anxiety, mood, impulsivity, sleep, ingestive behaviors, reward systems, and psychosis. Serotonergic dysfunction has been implicated in several neuropsychiatric conditions but efforts to more clearly understand the mechanisms of this influence have been hampered by the complexity of this system at the receptor level. There are at least 14 distinct receptors that mediate the effects of 5-HT as well as several enzymes that control its synthesis and metabolism. Pharmacologic agents that target specific receptors have provided clues regarding the function of these receptors in the adult brain. 5-HT is also an important modulator of neural development and several groups have employed a genetic strategy to ablate specific components of the 5-HT system in order to understand the role of different serotonergic in development of brain systems relevant to behavior. Several inactivation mutations of specific 5-HT receptors have been generated producing interesting behavioral phenotypes related to anxiety, depression, drug abuse, psychosis, and cognition. In many cases, knockout mice have been used to confirm what has already been suspected based on pharmacologic studies. In other instances, mutations have demonstrated new functions of serotonergic genes in development and behavior.

scholarly journals Generation and Behavior Characterization of CaMKIIβ Knockout Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e105191 ◽  
Author(s):  
Adam D. Bachstetter ◽  
Scott J. Webster ◽  
Tao Tu ◽  
Danielle S. Goulding ◽  
Jacques Haiech ◽  
...  
Keyword(s):  
Knockout Mice ◽  
And Behavior
Sign in / Sign up

Export Citation Format

Share Document