Nek4 regulates mitochondrial respiration and morphology

FEBS Journal ◽  
2022 ◽  
Author(s):  
Fernanda Luisa Basei ◽  
Camila de Castro Ferezin ◽  
Ana Luisa Rodrigues de Oliveira ◽  
Juan Pablo Muñoz ◽  
Antonio Zorzano ◽  
...  
Keyword(s):  
Mitochondrial Respiration

Metabolic endotoxaemia impairs mitochondrial respiration and insulin sensitivity in human adipocytes

2016 ◽  
Author(s):  
la Escalera Lucia Martinez de ◽  
Laura Jackisch ◽  
Alice Murphy ◽  
Milan Piya ◽  
Sudhesh Kumar ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Mitochondrial Respiration ◽  
Human Adipocytes

Continuous Adaptation of Rats to Hypobaric Hypoxia Prevents Stressor Hyperglycemia and Optimizes Mitochondrial Respiration in Acute Hypoxia

2013 ◽  
Vol 4 (2) ◽  
pp. 137-147
Author(s):  
Vladimir I. Portnichenko ◽  
Valentina I. Nosar ◽  
Alla M. Sydorenko ◽  
Alla G. Portnychenko ◽  
Irina N. Mankovska
Keyword(s):  
Mitochondrial Respiration ◽  
Hypobaric Hypoxia ◽  
Acute Hypoxia

Unaltered Fatty Acid Uptake, Utilization, and Mitochondrial Respiration in Right Atrial Appendage of Type 2 Diabetic Human Heart

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 335-OR
Author(s):  
NANDINI RJ ◽  
SR RAJI ◽  
VIVEK V. PILLAI ◽  
JAYAKUMAR K. ◽  
SRINIVAS GOPALA
Keyword(s):  
Fatty Acid ◽  
Mitochondrial Respiration ◽  
Human Heart ◽  
Fatty Acid Uptake ◽  
Atrial Appendage ◽  
Right Atrial ◽  
Acid Uptake ◽  
Right Atrial Appendage ◽  
Type 2 Diabetic

Cytotoxicity of Hydrazones of Morpholine Bearing Mannich Bases Towards Huh7 and T47D Cell Lines and Their Effects on Mitochondrial Respiration

2016 ◽  
Vol 13 (8) ◽  
pp. 734-741 ◽  
Author(s):  
Kaan Kucukoglu ◽  
Halise Inci Gul ◽  
Mustafa Gul ◽  
Rengul Cetin-Atalay ◽  
Yosra Baratli ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mitochondrial Respiration ◽  
T47d Cell ◽  
Mannich Bases

scholarly journals A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function

2021 ◽  
Author(s):  
Julius Honecker ◽  
Dominik Weidlich ◽  
Simone Heisz ◽  
Cecilia M. Lindgren ◽  
Dimitrios C. Karampinos ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mitochondrial Respiration ◽  
Mitochondrial Respiratory Chain ◽  
Cell Diameter ◽  
Adipocyte Size ◽  
Fat Cell ◽  
Positive Correlations ◽  
Size Estimates ◽  
Diameter Distributions ◽  
Mitochondrial Respiratory

Abstract Objective Cell diameter, area, and volume are established quantitative measures of adipocyte size. However, these different adipocyte sizing parameters have not yet been directly compared regarding their distributions. Therefore, the study aimed to investigate how these adipocyte size measures differ in their distribution and assessed their correlation with anthropometry and laboratory chemistry. In addition, we were interested to investigate the relationship between fat cell size and adipocyte mitochondrial respiratory chain capacity. Methods Subcutaneous and visceral histology-based adipocyte size estimates from 188 individuals were analyzed by applying a panel of parameters to describe the underlying cell population. Histology-based adipocyte diameter distributions were compared with adipocyte diameter distributions from collagenase digestion. Associations of mean adipocyte size with body mass index (BMI), glucose, HbA1C, blood lipids as well as mature adipocyte mitochondrial respiration were investigated. Results All adipocyte area estimates derived from adipose tissue histology were not normally distributed, but rather characterized by positive skewness. The shape of the size distribution depends on the adipocyte sizing parameter and on the method used to determine adipocyte size. Despite different distribution shapes histology-derived adipocyte area, diameter, volume, and surface area consistently showed positive correlations with BMI. Furthermore, associations between adipocyte sizing parameters and glucose, HbA1C, or HDL specifically in the visceral adipose depot were revealed. Increasing subcutaneous adipocyte diameter was negatively correlated with adipocyte mitochondrial respiration. Conclusions Despite different underlying size distributions, the correlation with obesity-related traits was consistent across adipocyte sizing parameters. Decreased mitochondrial respiratory capacity with increasing subcutaneous adipocyte diameter could display a novel link between adipocyte hypertrophy and adipose tissue function.

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