scholarly journals Interneuron development and dysfunction

FEBS Journal ◽  
2021 ◽  
Author(s):  
Jiaxin Yang ◽  
Xiong Yang ◽  
Ke Tang
Keyword(s):  
Interneuron Development

Endocannabinoid system in the neurodevelopment of GABAergic interneurons: implications for neurological and psychiatric disorders

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Chang-geng Song ◽  
Xin Kang ◽  
Fang Yang ◽  
Wan-qing Du ◽  
Jia-jia Zhang ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Endocannabinoid System ◽  
Autism Spectrum ◽  
Network Activity ◽  
Inhibitory Neurons ◽  
Gabaergic Interneurons ◽  
Neural Stem Progenitor Cells ◽  
The Central Nervous System ◽  
Interneuron Development

Abstract In mature mammalian brains, the endocannabinoid system (ECS) plays an important role in the regulation of synaptic plasticity and the functioning of neural networks. Besides, the ECS also contributes to the neurodevelopment of the central nervous system. Due to the increase in the medical and recreational use of cannabis, it is inevitable and essential to elaborate the roles of the ECS on neurodevelopment. GABAergic interneurons represent a group of inhibitory neurons that are vital in controlling neural network activity. However, the role of the ECS in the neurodevelopment of GABAergic interneurons remains to be fully elucidated. In this review, we provide a brief introduction of the ECS and interneuron diversity. We focus on the process of interneuron development and the role of ECS in the modulation of interneuron development, from the expansion of the neural stem/progenitor cells to the migration, specification and maturation of interneurons. We further discuss the potential implications of the ECS and interneurons in the pathogenesis of neurological and psychiatric disorders, including epilepsy, schizophrenia, major depressive disorder and autism spectrum disorder.

scholarly journals Molecular diversity and lineage commitment of human interneuron progenitors

2021 ◽  
Author(s):  
Dmitry Velmeshev ◽  
Manideep Chavali ◽  
Tomasz Jan Nowakowski ◽  
Mohini Bhade ◽  
Simone Mayer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Autism Spectrum ◽  
Lineage Commitment ◽  
Proper Function ◽  
Specific Gene ◽  
Specific Cell ◽  
Cortical Interneurons ◽  
Human Specific ◽  
Interneuron Development

Cortical interneurons are indispensable for proper function of neocortical circuits. Changes in interneuron development and function are implicated in human disorders, such as autism spectrum disorder and epilepsy. In order to understand human-specific features of cortical development as well as the origins of neurodevelopmental disorders it is crucial to identify the molecular programs underlying human interneuron development and subtype specification. Recent studies have explored gene expression programs underlying mouse interneuron specification and maturation. We applied single-cell RNA sequencing to samples of second trimester human ganglionic eminence and developing cortex to identify molecularly defined subtypes of human interneuron progenitors and immature interneurons. In addition, we integrated this data from the developing human ganglionic eminences and neocortex with single-nucleus RNA-seq of adult cortical interneurons in order to elucidate dynamic molecular changes associated with commitment of progenitors and immature interneurons to mature interneuron subtypes. By comparing our data with published mouse single-cell genomic data, we discover a number of divergent gene expression programs that distinguish human interneuron progenitors from mouse. Moreover, we find that a number of transcription factors expressed during prenatal development become restricted to adult interneuron subtypes in the human but not the mouse, and these adult interneurons express species- and lineage-specific cell adhesion and synaptic genes. Therefore, our study highlights that despite the similarity of main principles of cortical interneuron development and lineage commitment between mouse and human, human interneuron genesis and subtype specification is guided by species-specific gene programs, contributing to human-specific features of cortical inhibitory interneurons.

scholarly journals Interneuron Diversity: Toward a Better Understanding of Interneuron Development In the Olfactory System

2019 ◽  
Vol 13 ◽  
pp. 117906951982605
Author(s):  
Chi-Jen Yang ◽  
Kuo-Ting Tsai ◽  
Nan-Fu Liou ◽  
Ya-Hui Chou
Keyword(s):  
Olfactory System ◽  
Neural Circuits ◽  
Projection Neurons ◽  
Intrinsic Properties ◽  
Recent Advances ◽  
Local Interneurons ◽  
Olfactory Interneurons ◽  
High Diversity ◽  
Interneuron Development

The Drosophila olfactory system is an attractive model for exploring the wiring logic of complex neural circuits. Remarkably, olfactory local interneurons exhibit high diversity and variability in their morphologies and intrinsic properties. Although olfactory sensory and projection neurons have been extensively studied of development and wiring; the development, mechanisms for establishing diversity, and integration of olfactory local interneurons into the developing circuit remain largely undescribed. In this review, we discuss some challenges and recent advances in the study of Drosophila olfactory interneurons.

Intracerebroventricular kainic acid administration to neonatal rats alters interneuron development in the hippocampus

2003 ◽  
Vol 145 (1) ◽  
pp. 81-92 ◽  
Author(s):  
Hongxin Dong ◽  
Cynthia A. Csernansky ◽  
Yunxiang Chu ◽  
John G. Csernansky
Keyword(s):  
Kainic Acid ◽  
Neonatal Rats ◽  
Acid Administration ◽  
Interneuron Development

scholarly journals Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling

Development ◽  
2011 ◽  
Vol 138 (15) ◽  
pp. 3199-3211 ◽  
Author(s):  
K. Skaggs ◽  
D. M. Martin ◽  
B. G. Novitch
Keyword(s):  
Notch Signaling ◽  
Related Protein ◽  
Spinal Interneuron ◽  
Interneuron Development

scholarly journals 12-P014 Interneuron development in the Zebrafish spinal cord

2009 ◽  
Vol 126 ◽  
pp. S193
Author(s):  
Sarah de Jager ◽  
Gustavo Cerda ◽  
Jose Morales ◽  
Kate Lewis
Keyword(s):  
Spinal Cord ◽  
Interneuron Development
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