scholarly journals New insights on epigenetic mechanisms supporting axonal development: histone marks and miRNAs

FEBS Journal ◽  
2020 ◽  
Author(s):  
Carlos Wilson ◽  
Alfredo Cáceres
Keyword(s):  
Epigenetic Mechanisms ◽  
Histone Marks ◽  
Axonal Development

Prenatal Acintebacter lwoffii exposure leads to protection against experimentally induced asthma in mice by epigenetic mechanisms

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
D Kesper ◽  
S Brand ◽  
R Teich ◽  
T Dicke ◽  
H Garn ◽  
...  
Keyword(s):  
Epigenetic Mechanisms ◽  
Experimentally Induced

Understanding Schizophrenia: Genetic Causes and Treatment

2019 ◽  
Vol 1 (1) ◽  
pp. 6-12
Author(s):  
Fatima Javeria ◽  
Shazma Altaf ◽  
Alishah Zair ◽  
Rana Khalid Iqbal
Keyword(s):  
Copy Number ◽  
Drug Targets ◽  
Disease Risk ◽  
Mental Disease ◽  
Copy Number Variants ◽  
Aminobutyric Acid ◽  
Epigenetic Mechanisms ◽  
Gamma Aminobutyric Acid ◽  
Wide Range ◽  
Severe Mental Disease

Schizophrenia is a severe mental disease. The word schizophrenia literally means split mind. There are three major categories of symptoms which include positive, negative and cognitive symptoms. The disease is characterized by symptoms of hallucination, delusions, disorganized thinking and speech. Schizophrenia is related to many other mental and psychological problems like suicide, depression, hallucinations. Including these, it is also a problem for the patient’s family and the caregiver. There is no clear reason for the disease, but with the advances in molecular genetics; certain epigenetic mechanisms are involved in the pathophysiology of the disease. Epigenetic mechanisms that are mainly involved are the DNA methylation, copy number variants. With the advent of GWAS, a wide range of SNPs is found linked with the etiology of schizophrenia. These SNPs serve as ‘hubs’; because these all are integrating with each other in causing of schizophrenia risk. Until recently, there is no treatment available to cure the disease; but anti-psychotics can reduce the disease risk by minimizing its symptoms. Dopamine, serotonin, gamma-aminobutyric acid, are the neurotransmitters which serve as drug targets in the treatment of schizophrenia. Due to the involvement of genetic and epigenetic mechanisms, drugs available are already targeting certain genes involved in the etiology of the disease.

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