scholarly journals SWI/SNF chromatin remodelling complex contributes to clearance of cytoplasmic protein aggregates and regulates unfolded protein response in Saccharomyces cerevisiae

FEBS Journal ◽  
2020 ◽  
Vol 287 (14) ◽  
pp. 3024-3041 ◽  
Author(s):  
Rakesh Kumar Sahu ◽  
Nitu Saha ◽  
Laxmidhar Das ◽  
Pushpendra Kumar Sahu ◽  
Santhosh Kumar Sariki ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Unfolded Protein Response ◽  
Protein Aggregates ◽  
Chromatin Remodelling ◽  
Cytoplasmic Protein ◽  
Chromatin Remodelling Complex ◽  
Unfolded Protein ◽  
Protein Response

scholarly journals Overexpression of human virus surface glycoprotein precursors induces cytosolic unfolded protein response in Saccharomyces cerevisiae

2011 ◽  
Vol 10 (1) ◽  
pp. 37 ◽  
Author(s):  
Evaldas Čiplys ◽  
Dhanraj Samuel ◽  
Mindaugas Juozapaitis ◽  
Kęstutis Sasnauskas ◽  
Rimantas Slibinskas
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Unfolded Protein Response ◽  
Surface Glycoprotein ◽  
Virus Surface ◽  
Human Virus ◽  
Unfolded Protein ◽  
Protein Response

scholarly journals The Unfolded Protein Response: An Overview

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 384
Author(s):  
Adam Read ◽  
Martin Schröder
Keyword(s):  
Gene Expression ◽  
Saccharomyces Cerevisiae ◽  
Unfolded Protein Response ◽  
Protein Homeostasis ◽  
Unfolded Proteins ◽  
Unfolded Protein ◽  
Altered Glycosylation ◽  
Stressed Cells ◽  
The Unfolded Protein Response ◽  
Protein Response

The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR can be activated due to an accumulation of unfolded proteins. The activation of the UPR involves three signaling pathways, IRE1, PERK and ATF6, which all play vital roles in returning protein homeostasis to levels seen in non-stressed cells. IRE1 is the best studied of the three pathways, as it is the only pathway present in Saccharomyces cerevisiae. This pathway involves spliceosome independent splicing of HAC1 or XBP1 in yeast and mammalians cells, respectively. PERK limits protein synthesis, therefore reducing the number of new proteins requiring folding. ATF6 is translocated and proteolytically cleaved, releasing a NH2 domain fragment which is transported to the nucleus and which affects gene expression. If the UPR is unsuccessful at reducing the load of unfolded proteins in the ER and the UPR signals remain activated, this can lead to programmed cell death.

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