Mechanisms of promiscuity among drug metabolizing enzymes and drug transporters

William M. Atkins

doi:10.1111/febs.15116

Mechanisms of promiscuity among drug metabolizing enzymes and drug transporters

FEBS Journal ◽

10.1111/febs.15116 ◽

2019 ◽

Vol 287 (7) ◽

pp. 1306-1322 ◽

Cited By ~ 8

Author(s):

William M. Atkins

Keyword(s):

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes

Download Full-text

Genetic Polymorphism of Drug‐Metabolizing Enzymes and Drug Transporters in Drug Toxicity

Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity ◽

10.1002/9781119171003.ch5 ◽

2021 ◽

pp. 139-165

Author(s):

Ann K. Daly

Keyword(s):

Genetic Polymorphism ◽

Drug Toxicity ◽

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes

Download Full-text

Nuclear Receptors and the Regulation of Drug-Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs

The Journal of Clinical Pharmacology ◽

10.1177/0091270007299930 ◽

2007 ◽

Vol 47 (5) ◽

pp. 566-578 ◽

Cited By ~ 264

Author(s):

Bradley L. Urquhart ◽

Rommel G. Tirona ◽

Richard B. Kim

Keyword(s):

Nuclear Receptors ◽

Interindividual Variability ◽

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes

Download Full-text

Expression of clinically relevant drug‐metabolizing enzymes along the human intestine and their correlation to drug transporters and nuclear receptors: An intra‐subject analysis

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.13137 ◽

2018 ◽

Vol 124 (3) ◽

pp. 245-255 ◽

Cited By ~ 10

Author(s):

Anja Fritz ◽

Diana Busch ◽

Joanna Lapczuk ◽

Marek Ostrowski ◽

Marek Drozdzik ◽

...

Keyword(s):

Nuclear Receptors ◽

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Human Intestine ◽

Metabolizing Enzymes ◽

Subject Analysis

Download Full-text

MicroRNAs as regulators of drug transporters, drug-metabolizing enzymes, and tight junctions: Implication for intestinal barrier function

Pharmacology & Therapeutics ◽

10.1016/j.pharmthera.2014.03.002 ◽

2014 ◽

Vol 143 (2) ◽

pp. 217-224 ◽

Cited By ~ 30

Author(s):

Kenji Ikemura ◽

Takuya Iwamoto ◽

Masahiro Okuda

Keyword(s):

Tight Junctions ◽

Barrier Function ◽

Drug Transporters ◽

Intestinal Barrier ◽

Intestinal Barrier Function ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes

Download Full-text

Genotype Frequencies of Selected Drug Metabolizing Enzymes and ABC Drug Transporters among Breast Cancer Patients on FAC Chemotherapy

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/j.1742-7843.2009.00531.x ◽

2010 ◽

Vol 107 (1) ◽

pp. 570-576 ◽

Cited By ~ 14

Author(s):

Nasir Ali Afsar ◽

Sierk Haenisch ◽

Ahmed Mateen ◽

Ahmed Usman ◽

Mike Ufer ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Breast Cancer Patients ◽

Metabolizing Enzymes ◽

Genotype Frequencies ◽

Fac Chemotherapy

Download Full-text

Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes

Journal of Ethnopharmacology ◽

10.1016/j.jep.2018.01.026 ◽

2018 ◽

Vol 216 ◽

pp. 18-25 ◽

Cited By ~ 2

Author(s):

Chin-Shiu Huang ◽

Haw-Wen Chen ◽

Tzu-Yu Lin ◽

Ai-Hsuan Lin ◽

Chong-Kuei Lii

Keyword(s):

Drug Transporters ◽

Rat Hepatocytes ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes ◽

Primary Rat Hepatocytes

Download Full-text

Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes

Drug Metabolism and Disposition ◽

10.1124/dmd.121.000484 ◽

2021 ◽

pp. DMD-AR-2021-000484

Author(s):

Eman El-Khateeb ◽

Zubida M. Al-Majdoub ◽

Amin Rostami-Hodjegan ◽

Jill Barber ◽

Brahim Achour

Keyword(s):

Liver Cirrhosis ◽

Human Liver ◽

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes ◽

Human Liver Cirrhosis

Download Full-text

An Interethnic Comparison of Polymorphisms of the Genes Encoding Drug-Metabolizing Enzymes and Drug Transporters: Experience in Singapore

Drug Metabolism Reviews ◽

10.1081/dmr-28805 ◽

2005 ◽

Vol 37 (2) ◽

pp. 327-378 ◽

Cited By ~ 41

Author(s):

Balram Chowbay ◽

Shufeng Zhou ◽

Edmund J. D. Lee

Keyword(s):

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes ◽

Genes Encoding

Download Full-text

Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway

Drug Design Development and Therapy ◽

10.2147/dddt.s68501 ◽

2014 ◽

pp. 127 ◽

Cited By ~ 5

Author(s):

Shu-Feng Zhou ◽

Jin-lian He ◽

Zhi-Wei Zhou ◽

Juan-Juan Yin ◽

Chang-Qiang He ◽

...

Keyword(s):

Signaling Pathway ◽

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Schisandra Chinensis ◽

Metabolizing Enzymes

Download Full-text

Impact of enzalutamide and its main metaboliteN-desmethyl enzalutamide on pharmacokinetically important drug metabolizing enzymes and drug transporters

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2103 ◽

2017 ◽

Vol 38 (9) ◽

pp. 517-525 ◽

Cited By ~ 7

Author(s):

Johanna Weiss ◽

Jutta Kocher ◽

Corina Mueller ◽

Stephanie Rosenzweig ◽

Dirk Theile

Keyword(s):

Drug Transporters ◽

Drug Metabolizing Enzymes ◽

Metabolizing Enzymes ◽

Important Drug

Download Full-text