scholarly journals Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF 3 ubiquitination through recruiting OTUB 1

FEBS Journal ◽  
2019 ◽  
Vol 287 (2) ◽  
pp. 310-324
Author(s):  
Mengying Xie ◽  
Yue Yin ◽  
Liqian Chen ◽  
Aiping Yin ◽  
Yan Liu ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Hbv Infection ◽  
Interferon Response ◽  
Scavenger Receptor A

L-theanine inhibits foam cell formation via promoting the scavenger receptor A degradation

2021 ◽  
pp. 174181
Author(s):  
Jianzhen Lei ◽  
Jingheng Ye ◽  
Rong She ◽  
Ruyi Zhang ◽  
Yanan Wang ◽  
...  
Keyword(s):  
Foam Cell ◽  
Scavenger Receptor ◽  
Cell Formation ◽  
Foam Cell Formation ◽  
Scavenger Receptor A

scholarly journals Macrophage Scavenger Receptor A Mediates Adhesion to Apolipoproteins A-I and E

Biochemistry ◽  
2009 ◽  
Vol 48 (50) ◽  
pp. 11858-11871 ◽  
Author(s):  
Claudine Neyen ◽  
Annette Plüddemann ◽  
Pietro Roversi ◽  
Benjamin Thomas ◽  
Lei Cai ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Macrophage Scavenger Receptor ◽  
Scavenger Receptor A

Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A

2009 ◽  
Vol 46 (6) ◽  
pp. 1109-1119 ◽  
Author(s):  
Justyna Rzepecka ◽  
Sebastian Rausch ◽  
Christian Klotz ◽  
Corinna Schnöller ◽  
Tina Kornprobst ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Heligmosomoides Polygyrus ◽  
Intestinal Nematode ◽  
Scavenger Receptor A

SR-A/MARCO–mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens

Blood ◽  
2011 ◽  
Vol 117 (4) ◽  
pp. 1319-1328 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Audrey Varin ◽  
Yunying Chen ◽  
Baoying Liu ◽  
Karl Tryggvason ◽  
...  
Keyword(s):  
Cell Surface ◽  
Inflammatory Responses ◽  
Scavenger Receptor ◽  
Particle Uptake ◽  
Class A ◽  
Pyrin Domain ◽  
Intracellular Compartments ◽  
Scavenger Receptor A ◽  
Collagenous Structure ◽  
Oligomerization Domain

Abstract Phagocytic and pathogen sensing receptors are responsible for particle uptake and inflammation. It is unclear how these receptors' systems influence each other's function to shape an innate response. The class-A scavenger receptors SR-A (scavenger receptor A) and MARCO (macrophage receptor with collagenous structure) are 2 well-characterized phagocytic receptors that are unable to initiate inflammatory responses by themselves, yet are implicated in the pathogenesis of various inflammatory disorders. However, the mechanism for such an apparent discrepancy is still unclear. We utilized SR-A−/−, MARCO−/−, and SR-A−/−-MARCO−/− mice, along with microbe-derived, environmental, and synthetic polyanions to assess the inflammatory responses following combinatorial ligation of SR-A/MARCO and selected Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)–like receptors (NLRs) by their shared ligands. In addition to ligating SR-A and MARCO, these agonists also selectively activated the cell-surface sensor TLR4, endosomal TLR3, and the cytosolic NOD2 and NALP3 (NACHT domain–, leucine-rich repeat–, and pyrin domain–containing protein 3). We show that, following recognition of common ligands, SR-A and MARCO attenuate TLR4-mediated responses while enhancing responses by the intracellular TLR3, NOD2, and NALP3. We conclude that SR-A/MARCO-mediated rapid ligand internalization prevented sensing by surface TLRs while increasing ligand availability in intracellular compartments, thus allowing sensing and robust responses by intracellular sensors.

scholarly journals Clearance of Fetuin-A–Containing Calciprotein Particles Is Mediated by Scavenger Receptor-A

2012 ◽  
Vol 111 (5) ◽  
pp. 575-584 ◽  
Author(s):  
Marietta Herrmann ◽  
Cora Schäfer ◽  
Alexander Heiss ◽  
Steffen Gräber ◽  
Anne Kinkeldey ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Fetuin A ◽  
Calciprotein Particles ◽  
Scavenger Receptor A
Sign in / Sign up

Export Citation Format

Share Document