scholarly journals Death receptor 5 is activated by fucosylation in colon cancer cells

FEBS Journal ◽  
2019 ◽  
Vol 286 (3) ◽  
pp. 555-571 ◽  
Author(s):  
Baojie Zhang ◽  
Ingrid A. M. Roosmalen ◽  
Carlos R. Reis ◽  
Rita Setroikromo ◽  
Wim J. Quax
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Colon Cancer Cells

scholarly journals Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Mano Horinaka ◽  
Tatsushi Yoshida ◽  
Mitsuhiro Tomosugi ◽  
Shusuke Yasuda ◽  
Yoshihiro Sowa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Human Colon ◽  
Death Receptor 5 ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Sulindac Sulfide ◽  
Myeloid Zinc Finger ◽  
Human Colon Cancer Cells

scholarly journals Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL

2010 ◽  
Vol 285 (46) ◽  
pp. 35418-35427 ◽  
Author(s):  
Bokyung Sung ◽  
Jayaraj Ravindran ◽  
Sahdeo Prasad ◽  
Manoj K. Pandey ◽  
Bharat B. Aggarwal
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Colon Cancer Cells

scholarly journals 2-Methoxy-5-Amino-N-Hydroxybenzamide Sensitizes Colon Cancer Cells to TRAIL-Induced Apoptosis by Regulating Death Receptor 5 and Survivin Expression

2011 ◽  
Vol 10 (10) ◽  
pp. 1969-1981 ◽  
Author(s):  
Carmine Stolfi ◽  
Roberta Caruso ◽  
Eleonora Franzè ◽  
Angelamaria Rizzo ◽  
Angela Rotondi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Survivin Expression ◽  
Death Receptor 5 ◽  
Colon Cancer Cells ◽  
Induced Apoptosis

scholarly journals Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells

2012 ◽  
Vol 29 (2) ◽  
pp. 474-480 ◽  
Author(s):  
SAN-YUAN TANG ◽  
MEI-ZUO ZHONG ◽  
GUANG-JIN YUAN ◽  
SU-PING HOU ◽  
LEI-LAN YIN ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Colon Cancer Cells ◽  
Apoptotic Proteins ◽  
Induced Apoptosis

scholarly journals Epigallocatechin-3-Gallate Induces Apoptosis as a TRAIL Sensitizer via Activation of Caspase 8 and Death Receptor 5 in Human Colon Cancer Cells

Biomedicines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 84 ◽  
Author(s):  
Oh Sung Kwon ◽  
Ji Hoon Jung ◽  
Eun Ah Shin ◽  
Ji Eon Park ◽  
Woon Yi Park ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Caspase 8 ◽  
Mrna Levels ◽  
Death Receptor 5 ◽  
Colon Cancer Cells ◽  
Antitumor Effects ◽  
Hct116 Cells

Though epigallocatechin-3-gallate (EGCG), a major compound of green tea, has anti-diabetes, anti-obesity, anti-inflammatory, and antitumor effects, the underlying antitumor molecular mechanism of EGCG was not fully understood so far. Here the sensitizing effect of EGCG to tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) was examined in colorectal cancers. Cotreatment of EGCG and TRAIL synergistically enhanced cytotoxicity and sub G1 accumulation, increased the number of terminal deoxynucleotidyl transferase-dT-mediated dUTP nick end labelling (TUNEL)-positive cells in SW480 and HCT116 cells. Furthermore, this cotreatment promoted the cleavages of poly (adenosine diphosphate-ribose) polymerase (PARP) and induced caspase 8 activation compared to TRAIL or EGCG alone in SW480 and HCT116 cells. Of note, cotreatment of EGCG and TRAIL increased the expression of death receptor 5 (DR5) at protein and mRNA levels and also DR5 cell surface level in colon cancer cells. Conversely, depletion of DR5 reduced the apoptotic activity of cotreatment of EGCG and TRAIL to increase cytotoxicity, sub-G1 population and PARP cleavages in colon cancer cells. Overall, our findings provide evidence that EGCG can be a sensitizer of TRAIL via DR5 and caspase 8 mediated apoptosis in colorectal cancer cells.

Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells

2011 ◽  
Vol 301 (2) ◽  
pp. 193-202 ◽  
Author(s):  
C. Lepage ◽  
D.Y. Léger ◽  
J. Bertrand ◽  
F. Martin ◽  
J.L. Beneytout ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Colon Cancer Cells ◽  
Induced Apoptosis ◽  
P38 Pathway

scholarly journals Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.

2016 ◽  
Vol 291 (32) ◽  
pp. 16923-16923 ◽  
Author(s):  
Bokyung Sung ◽  
Jayaraj Ravindran ◽  
Sahdeo Prasad ◽  
Manoj K. Pandey ◽  
Bharat B. Aggarwal
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Death Receptor ◽  
Death Receptor 5 ◽  
Colon Cancer Cells
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