scholarly journals Identification of phosphorylation sites and binding pockets for modulation of Na V 1.5 channel by Fyn tyrosine kinase

FEBS Journal ◽  
2018 ◽  
Vol 285 (13) ◽  
pp. 2520-2530 ◽  
Author(s):  
Shahid Muhammad Iqbal ◽  
Mohammed Aufy ◽  
Waheed Shabbir ◽  
Rosa Lemmens‐Gruber
Keyword(s):  
Tyrosine Kinase ◽  
Phosphorylation Sites ◽  
Binding Pockets ◽  
Fyn Tyrosine Kinase

scholarly journals Fyn Tyrosine Kinase in Sertoli Cells Is Involved in Mouse Spermatogenesis1

2002 ◽  
Vol 66 (1) ◽  
pp. 211-221 ◽  
Author(s):  
Mamiko Maekawa ◽  
Yoshiro Toyama ◽  
Masahiro Yasuda ◽  
Takeshi Yagi ◽  
Shigeki Yuasa
Keyword(s):  
Tyrosine Kinase ◽  
Sertoli Cells ◽  
Fyn Tyrosine Kinase

Brain Migration Disorder and T-Cell Activation Deficiency Associated with Abnormal Signaling through TCR/CD3 Complex and Hyperactivity of Fyn Tyrosine Kinase*

2000 ◽  
Vol 31 (5) ◽  
pp. 265-268 ◽  
Author(s):  
E. Del Giudice ◽  
L. Gaetaniello ◽  
E. Matrecano ◽  
E. Cosentini ◽  
M.V. Ursini ◽  
...  
Keyword(s):  
T Cell ◽  
Tyrosine Kinase ◽  
T Cell Activation ◽  
Cell Activation ◽  
Migration Disorder ◽  
Fyn Tyrosine Kinase

scholarly journals Regulation of Jak2 Function by Phosphorylation of Tyr317 and Tyr637 during Cytokine Signaling

2009 ◽  
Vol 29 (12) ◽  
pp. 3367-3378 ◽  
Author(s):  
Scott A. Robertson ◽  
Rositsa I. Koleva ◽  
Lawrence S. Argetsinger ◽  
Christin Carter-Su ◽  
Jarrod A. Marto ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Feedback Inhibition ◽  
Dominant Role ◽  
Kinase Domain ◽  
Cytokine Signaling ◽  
Tyrosine Kinase Domain ◽  
Phosphorylation Sites ◽  
Cytokine Stimulation

ABSTRACT Jak2, the cognate tyrosine kinase for numerous cytokine receptors, undergoes multisite phosphorylation during cytokine stimulation. To understand the role of phosphorylation in Jak2 regulation, we used mass spectrometry to identify numerous Jak2 phosphorylation sites and characterize their significance for Jak2 function. Two sites outside of the tyrosine kinase domain, Tyr317 in the FERM domain and Tyr637 in the JH2 domain, exhibited strong regulation of Jak2 activity. Mutation of Tyr317 promotes increased Jak2 activity, and the phosphorylation of Tyr317 during cytokine signaling requires prior activation loop phosphorylation, which is consistent with a role for Tyr317 in the feedback inhibition of Jak2 kinase activity after receptor stimulation. Comparison to several previously identified regulatory phosphorylation sites on Jak2 revealed a dominant role for Tyr317 in the attenuation of Jak2 signaling. In contrast, mutation of Tyr637 decreased Jak2 signaling and activity and partially suppressed the activating JH2 V617F mutation, suggesting a role for Tyr637 phosphorylation in the release of JH2 domain-mediated suppression of Jak2 kinase activity during cytokine stimulation. The phosphorylation of Tyr317 and Tyr637 act in concert with other regulatory events to maintain appropriate control of Jak2 activity and cytokine signaling.

scholarly journals Phosphorylation sites of protein kinase C   in H2O2-treated cells and its activation by tyrosine kinase in vitro

2001 ◽  
Vol 98 (12) ◽  
pp. 6587-6592 ◽  
Author(s):  
H. Konishi ◽  
E. Yamauchi ◽  
H. Taniguchi ◽  
T. Yamamoto ◽  
H. Matsuzaki ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Phosphorylation Sites ◽  
Kinase C

Fyn Tyrosine Kinase Reduces the Ethanol Inhibition of Recombinant NR1/NR2A but Not NR1/NR2B NMDA Receptors Expressed in HEK 293 Cells

2001 ◽  
Vol 72 (4) ◽  
pp. 1389-1393 ◽  
Author(s):  
Douglas L. Anders ◽  
Tana Blevins ◽  
Greg Sutton ◽  
Sheridan Swope ◽  
L. Judson Chandler ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Nmda Receptors ◽  
Ethanol Inhibition ◽  
Hek 293 ◽  
Hek 293 Cells ◽  
293 Cells ◽  
Fyn Tyrosine Kinase

scholarly journals Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase

2017 ◽  
Vol 37 (30) ◽  
pp. 7125-7139 ◽  
Author(s):  
Fumio Nakamura ◽  
Takako Okada ◽  
Maria Shishikura ◽  
Noriko Uetani ◽  
Masahiko Taniguchi ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Dendritic Arborization ◽  
Protein Tyrosine ◽  
Fyn Tyrosine Kinase

scholarly journals Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion

1999 ◽  
Vol 13 (23) ◽  
pp. 3125-3135 ◽  
Author(s):  
A. Davy ◽  
N. W. Gale ◽  
E. W. Murray ◽  
R. A. Klinghoffer ◽  
P. Soriano ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Cellular Adhesion ◽  
Fyn Tyrosine Kinase
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