scholarly journals Identification and characterization of GmPDIL7, a soybean ER membrane‐bound protein disulfide isomerase family protein

FEBS Journal ◽  
2016 ◽  
Vol 284 (3) ◽  
pp. 414-428 ◽  
Author(s):  
Aya Okuda ◽  
Motonori Matsusaki ◽  
Taro Masuda ◽  
Reiko Urade
Keyword(s):  
Protein Disulfide Isomerase ◽  
Disulfide Isomerase ◽  
Family Protein ◽  
Membrane Bound ◽  
Protein Disulfide ◽  
Identification And Characterization ◽  
Protein Disulfide Isomerase Family ◽  
Er Membrane

Characterization of Aspergillus fumigatus protein disulfide isomerase family gene

Gene ◽  
2001 ◽  
Vol 281 (1-2) ◽  
pp. 143-150 ◽  
Author(s):  
Shailly Nigam ◽  
P.V.G.K Sarma ◽  
P.C Ghosh ◽  
P.Usha Sarma
Keyword(s):  
Aspergillus Fumigatus ◽  
Protein Disulfide Isomerase ◽  
Disulfide Isomerase ◽  
Family Gene ◽  
Protein Disulfide ◽  
Protein Disulfide Isomerase Family

Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs

FEBS Journal ◽  
2009 ◽  
Vol 276 (15) ◽  
pp. 4130-4141 ◽  
Author(s):  
Kensuke Iwasaki ◽  
Shinya Kamauchi ◽  
Hiroyuki Wadahama ◽  
Masao Ishimoto ◽  
Teruo Kawada ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Active Center ◽  
Protein Disulfide Isomerase ◽  
Soybean Protein ◽  
Disulfide Isomerase ◽  
Protein Disulfide ◽  
Protein Disulfide Isomerase Family

scholarly journals Expression and characterization of protein disulfide isomerase family proteins in bread wheat

2015 ◽  
Vol 15 (1) ◽  
pp. 73 ◽  
Author(s):  
Shizuka Kimura ◽  
Yuki Higashino ◽  
Yuki Kitao ◽  
Taro Masuda ◽  
Reiko Urade
Keyword(s):  
Bread Wheat ◽  
Protein Disulfide Isomerase ◽  
Disulfide Isomerase ◽  
Protein Disulfide ◽  
Protein Disulfide Isomerase Family

scholarly journals Structure-Function Analysis of the Endoplasmic Reticulum Oxidoreductase TMX3 Reveals Interdomain Stabilization of the N-terminal Redox-active Domain

2007 ◽  
Vol 282 (46) ◽  
pp. 33859-33867 ◽  
Author(s):  
Johannes Haugstetter ◽  
Michael Andreas Maurer ◽  
Thomas Blicher ◽  
Martin Pagac ◽  
Gerhard Wider ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Disulfide Isomerase ◽  
Function Analysis ◽  
Transmembrane Protein ◽  
Reduced Form ◽  
Disulfide Isomerase ◽  
Binding Domains ◽  
Redox Active ◽  
Protein Disulfide ◽  
Protein Disulfide Isomerase Family

Disulfide bond formation in the endoplasmic reticulum is catalyzed by enzymes of the protein disulfide-isomerase family that harbor one or more thioredoxin-like domains. We recently discovered the transmembrane protein TMX3, a thiol-disulfide oxidoreductase of the protein disulfide-isomerase family. Here, we show that the endoplasmic reticulum-luminal region of TMX3 contains three thioredoxin-like domains, an N-terminal redox-active domain (named a) followed by two enzymatically inactive domains (b and b′). Using the recombinantly expressed TMX3 domain constructs a, ab, and abb′, we compared structural stability and enzymatic properties. By structural and biophysical methods, we demonstrate that the reduced a domain has features typical of a globular folded domain that is, however, greatly destabilized upon oxidization. Importantly, interdomain stabilization by the b domain renders the a domain more resistant toward chemical denaturation and proteolysis in both the oxidized and reduced form. In combination with molecular modeling studies of TMX3 abb′, the experimental results provide a new understanding of the relationship between the multidomain structure of TMX3 and its function as a redox enzyme. Overall, the data indicate that in addition to their role as substrate and co-factor binding domains, redox-inactive thioredoxin-like domains also function in stabilizing neighboring redox-active domains.

scholarly journals Nuclear magnetic resonance characterization of the N-terminal thioredoxin-like domain of protein disulfide isomerase

1995 ◽  
Vol 4 (12) ◽  
pp. 2587-2593 ◽  
Author(s):  
Johan Kemmink ◽  
Nigel J. Darby ◽  
Thomas E. Creighton ◽  
Klaas Dijkstra ◽  
Ruud M. Scheek
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Protein Disulfide Isomerase ◽  
Disulfide Isomerase ◽  
Protein Disulfide ◽  
Nuclear Magnetic

scholarly journals Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma

Leukemia ◽  
2018 ◽  
Vol 33 (4) ◽  
pp. 1011-1022 ◽  
Author(s):  
Reeder M. Robinson ◽  
Leticia Reyes ◽  
Ravyn M. Duncan ◽  
Haiyan Bian ◽  
Allen B. Reitz ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Protein Disulfide Isomerase ◽  
Disulfide Isomerase ◽  
Protein Disulfide ◽  
Protein Disulfide Isomerase Family
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