scholarly journals Loss of ppr3 , ppr4 , ppr6 , or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe

FEBS Journal ◽  
2017 ◽  
Vol 284 (2) ◽  
pp. 324-337 ◽  
Author(s):  
Yang Su ◽  
Yanmei Yang ◽  
Ying Huang
Keyword(s):  
Cell Death ◽  
Schizosaccharomyces Pombe ◽  
Iron Homeostasis ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

scholarly journals Oxidative stress-mediated apoptotic cell death induced by camphor in sod1-deficient Schizosaccharomyces pombe

2019 ◽  
Vol 8 (2) ◽  
pp. 216-226 ◽  
Author(s):  
Hizlan Hincal Agus ◽  
Cansin Ogeday Sengoz ◽  
Sedanur Yilmaz
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Schizosaccharomyces Pombe ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death

Camphor induces oxidative stress-mediated apoptotic cell death.

scholarly journals Oxidative stress and mitochondrial impairment mediated apoptotic cell death induced by terpinolene in Schizosaccharomyces pombe

2018 ◽  
Vol 7 (5) ◽  
pp. 848-858 ◽  
Author(s):  
Hizlan H. Agus ◽  
Cemaynur Sarp ◽  
Meryem Cemiloglu
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Schizosaccharomyces Pombe ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Mitochondrial Impairment

Terpinolene induces apoptotic cell death via oxidative stress and mitochondrial impairment.

scholarly journals Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe)

2020 ◽  
Vol 20 (4) ◽  
Author(s):  
Hizlan Hincal Agus ◽  
Gizem Kok ◽  
Ezgi Derinoz ◽  
Didem Oncel ◽  
Sedanur Yilmaz
Keyword(s):  
Cell Death ◽  
Schizosaccharomyces Pombe ◽  
Cell Biology ◽  
Apoptotic Cell ◽  
Survival Rates ◽  
Model Organism ◽  
Apoptotic Cell Death ◽  
Dependent Manner ◽  
Induced Apoptosis ◽  
Apoptotic Factors

ABSTRACT Alpha-thujone, widely used in beverages (1–5 mg/kg), is known to have cytotoxic effects, but the mode of action and the role of potential apoptotic proteins in yeast cell death should be unraveled. In this study, we used Schizosaccharomyces pombe, which is a promising unicellular model organism in mechanistic toxicology and cell biology, to investigate the involvement of pro-apoptotic factors in alpha-thujone-induced cell death. We showed alpha-thujone-induced ROS accumulation-dependent cytotoxicity and apoptosis. In addition, we used superoxide dismutase-deficient cells (sod1 and sod2 mutants) to understand the effect of oxidative stress. Alpha-thujone caused significant cytotoxicity and apoptotic cell death, particularly in sod mutants. Moreover, two potential apoptotic factors, pca1 and pnu1 (pombe caspase-1 and pombe nuc1) were investigated to understand which factor mediates alpha-thujone-induced cell death. Pca1-deficient cells showed increased survival rates and reduced apoptosis in comparison to parental cells after chemical treatment while pnu1 mutation did not cause any significant change and the response was found identical as of parental cells. Yeast responded to alpha-thujone in caspase-dependent manner which was very similar to that for acetic acid. In conclusion, alfa-thujone-induced apoptosis and accounting mechanisms, which were mediated by ROS and driven by Pca1, were clarified in the unicellular model, S. pombe.

KIOM-79 prevents apoptotic cell death and AGEs accumulation in the retina of diabetic db/db mice

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
YS Kim ◽  
EJ Sohn ◽  
HY Lee ◽  
CS Kim ◽  
YM Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death
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