Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs

FEBS Journal ◽  
2016 ◽  
Vol 283 (19) ◽  
pp. 3613-3625 ◽  
Author(s):  
Sang Jae Lee ◽  
Jang-Sik Choi ◽  
Byeong-Gu Han ◽  
Hyoun Sook Kim ◽  
Ho-Juhn Song ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Crystal Structures ◽  
Anticancer Drugs ◽  
Spleen Tyrosine Kinase ◽  
Structural Insights

Structure-based Drugs Design Studies on Spleen Tyrosine Kinase Inhibitors

2016 ◽  
Vol 13 (9) ◽  
pp. 845-858
Author(s):  
Letícia Cristina Assis ◽  
Letícia Santos Garcia ◽  
Daiana Teixeira Mancini ◽  
Tamiris Maria Assis ◽  
Daniela Rodrigues Silva ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Spleen Tyrosine Kinase ◽  
Design Studies

scholarly journals Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design

RSC Advances ◽  
2021 ◽  
Vol 11 (31) ◽  
pp. 18938-18944
Author(s):  
Jia-Hong Lei ◽  
Ling-Ling Ma ◽  
Jing-Hong Xian ◽  
Hai Chen ◽  
Jian-Jian Zhou ◽  
...  
Keyword(s):  
Drug Design ◽  
Binding Site ◽  
Crystal Structures ◽  
Rational Drug Design ◽  
Colchicine Binding Site ◽  
Rational Drug ◽  
Structural Insights

Crystal structures of tubulin complexed with ELR510444 and parbendazole facilitate the design of novel colchicine binding site inhibitors.

scholarly journals Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2453-2461
Author(s):  
Min-Che Tung ◽  
Keng-Chang Tsai ◽  
Kit-Man Fung ◽  
Ming-Jaw Don ◽  
Tien-Sheng Tseng
Keyword(s):  
Natural Products ◽  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Mode Of Action ◽  
Drug Target ◽  
Receptor Protein ◽  
Inflammatory Disorder ◽  
Spleen Tyrosine Kinase ◽  
Structure Activity Relationships ◽  
Structure Activity

The cytosolic non-receptor protein kinase, spleen tyrosine kinase (SYK), is an attractive drug target in autoimmune, inflammatory disorder, and cancers indications.

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