scholarly journals CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity - role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments

FEBS Journal ◽  
2014 ◽  
Vol 281 (21) ◽  
pp. 4878-4891 ◽  
Author(s):  
Cheng-Chih Hsiao ◽  
Wen-Chih Wang ◽  
Wan-Lin Kuo ◽  
Hsin-Yi Chen ◽  
Tse-Ching Chen ◽  
...  
Keyword(s):  
Cell Migration ◽  
Fibrosarcoma Cells ◽  
Human Fibrosarcoma Cells

Adhesion dynamics and cytoskeletal structure of gliding human fibrosarcoma cells: a hypothetical model of cell migration

2003 ◽  
Vol 290 (2) ◽  
pp. 246-253 ◽  
Author(s):  
Sándor Paku ◽  
József Tóvári ◽  
Zsolt Lörincz ◽  
Ferenc Timár ◽  
Balázs Döme ◽  
...  
Keyword(s):  
Cell Migration ◽  
Hypothetical Model ◽  
Cytoskeletal Structure ◽  
Fibrosarcoma Cells ◽  
Human Fibrosarcoma Cells

scholarly journals Antioxidant Peptide Derived fromSpirulina maximaSuppresses HIF1α-Induced Invasive Migration of HT1080 Fibrosarcoma Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Won Suk Kim ◽  
Won Kyo Jung ◽  
Sun Joo Park
Keyword(s):  
Cell Migration ◽  
Signaling Pathway ◽  
Ros Generation ◽  
Antioxidant Peptide ◽  
Intracellular Ros ◽  
Fibrosarcoma Cells ◽  
Ht1080 Cells ◽  
Human Fibrosarcoma Cells ◽  
Invasive Cell ◽  
Effective Cancer Therapy

Hypoxia causes the malignant progression of tumor cells; hence, it has been considered a central issue that must be addressed for effective cancer therapy. The initiation of tumor metastasis requires invasive cell migration. Here, we show that an antioxidant peptide derived fromSpirulina maximasuppresses hypoxia-induced invasive migration of HT1080 human fibrosarcoma cells. HT1080 cells treated with a hypoxia-inducing agent, CoCl2, exhibited an increase in invasive migration and intracellular reactive oxygen species (ROS), which is associated with an increase in the expression of hypoxia-induced factor 1α(HIF1α) accompanied by the activation of PI3K/Akt and ERK1/2. The inhibition of PI3K/Akt and ERK1/2 with specific inhibitors diminished the CoCl2-induced increase in HIF1αexpression and invasive cell migration. Moreover, CoCl2-induced HIF1αexpression was associated with an increase in the expression of molecules downstream ofβ-integrin, such as N-cadherin, vimentin, andβ-catenin. Therefore, theS. maximapeptide effectively attenuated the CoCl2-induced ROS generation and downregulated the HIF1αsignaling pathway involving PI3K/Akt, ERK1/2, andβ-integrin in cells. These results suggest that theS. maximaantioxidant peptide downregulates the HIF1αsignaling pathway necessary for hypoxia-induced invasive migration of HT1080 cells by attenuating intracellular ROS.S. maximapeptide may be an effective constituent in antitumor progression products.

A novel role of Rho-kinase in the regulation of ligand-induced phosphorylated EGFR endocytosis via the early/late endocytic pathway in human fibrosarcoma cells

2011 ◽  
Vol 42 (5) ◽  
pp. 427-442 ◽  
Author(s):  
Yukio Nishimura ◽  
Biborka Bereczky ◽  
Kiyoko Yoshioka ◽  
Shun’ichiro Taniguchi ◽  
Kazuyuki Itoh
Keyword(s):  
Rho Kinase ◽  
Endocytic Pathway ◽  
Fibrosarcoma Cells ◽  
Human Fibrosarcoma Cells ◽  
Early Late

The role of DUBs in the post-translational control of cell migration

2019 ◽  
Vol 63 (5) ◽  
pp. 579-594 ◽  
Author(s):  
Guillem Lambies ◽  
Antonio García de Herreros ◽  
Víctor M. Díaz
Keyword(s):  
Cell Migration ◽  
Translational Control ◽  
Epithelial To Mesenchymal Transition ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Mesenchymal Transition ◽  
Tgfβ Receptors ◽  
Fundamental Process ◽  
Multistep Process

Abstract Cell migration is a multifactorial/multistep process that requires the concerted action of growth and transcriptional factors, motor proteins, extracellular matrix remodeling and proteases. In this review, we focus on the role of transcription factors modulating Epithelial-to-Mesenchymal Transition (EMT-TFs), a fundamental process supporting both physiological and pathological cell migration. These EMT-TFs (Snail1/2, Twist1/2 and Zeb1/2) are labile proteins which should be stabilized to initiate EMT and provide full migratory and invasive properties. We present here a family of enzymes, the deubiquitinases (DUBs) which have a crucial role in counteracting polyubiquitination and proteasomal degradation of EMT-TFs after their induction by TGFβ, inflammatory cytokines and hypoxia. We also describe the DUBs promoting the stabilization of Smads, TGFβ receptors and other key proteins involved in transduction pathways controlling EMT.

Role of GSK-3β in hepatocellular carcinoma cell migration

2010 ◽  
Vol 30 (1) ◽  
pp. 28-32
Author(s):  
Jian-fei WANG ◽  
Ying HOU ◽  
Rui-liang GE ◽  
Yi-zheng WANG ◽  
Feng SHEN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Migration ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Gsk 3Β
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