scholarly journals A role for Ral GTPase-activating protein subunit β in mitotic regulation

FEBS Journal ◽  
2014 ◽  
Vol 281 (13) ◽  
pp. 2977-2989 ◽  
Author(s):  
Nicolas Personnic ◽  
Goran Lakisic ◽  
Edith Gouin ◽  
Alix Rousseau ◽  
Alexis Gautreau ◽  
...  
Keyword(s):  
Gtpase Activating Protein ◽  
Protein Subunit ◽  
Ral Gtpase ◽  
Mitotic Regulation

scholarly journals Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

Oncogene ◽  
2012 ◽  
Vol 32 (7) ◽  
pp. 894-902 ◽  
Author(s):  
R Saito ◽  
R Shirakawa ◽  
H Nishiyama ◽  
T Kobayashi ◽  
M Kawato ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Invasion ◽  
Gtpase Activating Protein ◽  
Invasion And Metastasis ◽  
Ral Gtpase

scholarly journals The Ral GTPase‐activating protein regulates the malignancy of pancreatic ductal adenocarcinoma

2021 ◽  
Author(s):  
Shingo Yoshimachi ◽  
Ryutaro Shirakawa ◽  
Mingxin Cao ◽  
Duc Anh Trinh ◽  
Pan Gao ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Gtpase Activating Protein ◽  
Ral Gtpase

Mutations in G-protein subunit [alpha]q(GNAQ) are not a cause of familial hypocalciuric hypercalcaemia

2015 ◽  
Author(s):  
Manish Modi ◽  
Treena Cranston ◽  
Angela Rogers ◽  
Sarah Howles ◽  
Caroline Gorvin ◽  
...  
Keyword(s):  
G Protein ◽  
Protein Subunit

ARFGAP3 an androgen target gene promotes prostate cancer cell proliferation and migration.

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cell Biology ◽  
Adaptor Protein ◽  
Cancer Cell Proliferation ◽  
Lncap Cells ◽  
Gtpase Activating Protein ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

ADP ribosylation factor GTPase-activating protein 3 (ARFGAP3) is a GTPase-activating protein that associates with the Golgiapparatus and regulates the vesicular trafficking pathway. In the present study, we examined the contribution of ARFGAP3 toprostate cancer cell biology. We showed that ARFGAP3 expression was induced by 100 nM of dihydrotestosterone (DHT) atboth the mRNA and protein levels in androgen-sensitive LNCaP cells. We generated stable transfectants of LNCaP cells withFLAG-tagged ARFGAP3 or a control empty vector and showed that ARFGAP3 overexpression promoted cell proliferation andmigration compared with control cells. We found that ARFGAP3 interacted with paxillin, a focal adhesion adaptor protein thatis important for cell mobility and migration. Small interfering RNA (siRNA)-mediated knockdown of ARFGAP3 showed thatARFGAP3 siRNA markedly reduced LNCaP cell growth. Androgen receptor (AR)-dependent transactivation activity on prostatespecificantigen (PSA) enhancer was synergistically promoted by exogenous ARFGAP3 and paxillin expression, as shown byluciferase assay in LNCaP cells. Thus, our results suggest that ARFGAP3 is a novel androgen-regulated gene that can promoteprostate cancer cell proliferation and migration in collaboration with paxillin.

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