scholarly journals Fusogenic properties of the ectodomains of hepatitis C virus envelope proteins

FEBS Journal ◽  
2014 ◽  
Vol 281 (11) ◽  
pp. 2558-2569 ◽  
Author(s):  
Daniel Tello ◽  
Mar Rodríguez-Rodríguez ◽  
Sara Ortega ◽  
Laura Lombana ◽  
Belén Yélamos ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Proteins ◽  
Virus Envelope

scholarly journals Functional Analysis of Hepatitis C Virus Envelope Proteins, Using a Cell-Cell Fusion Assay

2006 ◽  
Vol 80 (4) ◽  
pp. 1817-1825 ◽  
Author(s):  
Mariko Kobayashi ◽  
Michael C. Bennett ◽  
Theodore Bercot ◽  
Ila R. Singh
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cell Fusion ◽  
Viral Entry ◽  
Antiviral Agents ◽  
Cell Types ◽  
Envelope Proteins ◽  
Virus Envelope ◽  
Host Cell Membrane ◽  
Cell Cell

ABSTRACT Hepatitis C virus (HCV) envelope proteins mediate the entry of virus into cells by binding to cellular receptors, resulting in fusion of the viral membrane with the host cell membrane and permitting the viral genome to enter the cytoplasm. We report the development of a robust and reproducible cell-cell fusion assay using envelope proteins from commonly occurring genotypes of HCV. The assay scored HCV envelope protein-mediated fusion by the production of fluorescent green syncytia and allowed us to elucidate many aspects of HCV fusion, including the pH of fusion, cell types that permit viral entry, and the conformation of envelope proteins essential for fusion. We found that fusion could be specifically inhibited by anti-HCV antibodies and by at least one peptide. We also generated a number of insertional mutations in the envelope proteins and tested nine of these using the fusion assay. We demonstrate that this fusion assay is a powerful tool for understanding the mechanism of HCV-mediated fusion, elucidating mutant function, and testing antiviral agents.

Immunodominant B-cell domains of hepatitis C virus envelope proteins E1 and E2 identified during early and late time points of infection

1999 ◽  
Vol 30 (2) ◽  
pp. 177-184 ◽  
Author(s):  
Andree Zibert ◽  
Wolfgang Kraas ◽  
R.Stefan Ross ◽  
Helga Meisel ◽  
Sabine Lechner ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Envelope Proteins ◽  
Late Time ◽  
Virus Envelope ◽  
Time Points

Glycosylation of hepatitis C virus envelope proteins

Biochimie ◽  
2003 ◽  
Vol 85 (3-4) ◽  
pp. 295-301 ◽  
Author(s):  
Anne Goffard ◽  
Jean Dubuisson
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Proteins ◽  
Virus Envelope

scholarly journals Immunoglobulin allotypes influence IgG antibody responses to hepatitis C virus envelope proteins E1 and E2

2008 ◽  
Vol 69 (3) ◽  
pp. 158-164 ◽  
Author(s):  
Janardan P. Pandey ◽  
Yuqun Luo ◽  
Robert C. Elston ◽  
Yuping Wu ◽  
Frances Hite Philp ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Proteins ◽  
Antibody Responses ◽  
Igg Antibody ◽  
Virus Envelope ◽  
Immunoglobulin Allotypes

scholarly journals Evaluation of a Recombinant Measles Virus as the Expression Vector of Hepatitis C Virus Envelope Proteins

2011 ◽  
Vol 01 (03) ◽  
pp. 98-103 ◽  
Author(s):  
Yuri Kasama ◽  
Masaaki Satoh ◽  
Makoto Saito ◽  
Seiji Okada ◽  
Chieko Kai ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Measles Virus ◽  
Expression Vector ◽  
Envelope Proteins ◽  
Virus Envelope

scholarly journals Hepatitis C virus envelope proteins bind lactoferrin.

1997 ◽  
Vol 71 (8) ◽  
pp. 5997-6002 ◽  
Author(s):  
M Yi ◽  
S Kaneko ◽  
D Y Yu ◽  
S Murakami
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Proteins ◽  
Virus Envelope
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