scholarly journals Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability

FEBS Journal ◽  
2014 ◽  
Vol 281 (3) ◽  
pp. 802-813 ◽  
Author(s):  
Feng Yang ◽  
Xuchao Xue ◽  
Luming Zheng ◽  
Jianwei Bi ◽  
Yuhong Zhou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastric Carcinoma ◽  
Mrna Stability ◽  
Carcinoma Cell ◽  
Gastric Carcinoma Cell ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Exosomal circ_0088300 Derived From Cancer-Associated Fibroblasts Acts as a miR-1305 Sponge and Promotes Gastric Carcinoma Cell Tumorigenesis

2021 ◽  
Vol 9 ◽  
Author(s):  
Hao Shi ◽  
Shan Huang ◽  
Mingde Qin ◽  
Xiaofeng Xue ◽  
Xingpo Guo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastric Carcinoma ◽  
Carcinoma Cell ◽  
Migration And Invasion ◽  
Circular Rnas ◽  
Cancer Associated Fibroblasts ◽  
Regulatory Pathway ◽  
Gastric Carcinoma Cell ◽  
Cancer Associated Fibroblast ◽  
Potential Biomarker

Cancer-associated fibroblast (CAF)-derived exosomes play a major role in gastric carcinoma (GC) tumorigenesis. However, the mechanism behind the activity of circular RNAs in CAF-derived exosomes in GC remains unclear. In the present study, we identified differentially expressed circ_0088300 in GC tissues and plasma exosomes. We found that CAFs delivered functional circ_0088300 to GC tumor cells via exosomes and promoted the proliferation, migration and invasion abilities of GC cells. Furthermore, we demonstrated that circ_0088300 packaging into exosomes was driven by KHDRBS3. In addition, we verified that circ_0088300 served as a sponge that directly targeted miR-1305 and promoted GC cell proliferation, migration and invasion. Finally, the JAK/STAT signaling pathway was found to be involved in the circ_0088300/miR-1305 axis, which accelerates GC tumorigenesis. In conclusion, our results indicated a previously unknown regulatory pathway in which exosomal circ_0088300 derived from CAFs acts as a sponge of miR-1305 and promotes GC cell proliferation, migration and invasion; these data identify a potential biomarker and novel therapeutic target for GC in the future.

scholarly journals Depletion of MRPL35 inhibits gastric carcinoma cell proliferation by regulating downstream signaling proteins

2021 ◽  
Vol 27 (16) ◽  
pp. 1785-1804
Author(s):  
Ling Yuan ◽  
Jia-Xin Li ◽  
Yi Yang ◽  
Yan Chen ◽  
Ting-Ting Ma ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastric Carcinoma ◽  
Carcinoma Cell ◽  
Signaling Proteins ◽  
Gastric Carcinoma Cell ◽  
Downstream Signaling

scholarly journals Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation

2018 ◽  
Vol 13 ◽  
pp. 312-321 ◽  
Author(s):  
Xi Liu ◽  
John M. Abraham ◽  
Yulan Cheng ◽  
Zhixiong Wang ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastric Carcinoma ◽  
Carcinoma Cell ◽  
Circular Rna ◽  
Gastric Carcinoma Cell
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