The interleukin-6-type cytokine oncostatin M induces aryl hydrocarbon receptor expression in a STAT3-dependent manner in human HepG2 hepatoma cells

FEBS Journal ◽  
2013 ◽  
Vol 280 (24) ◽  
pp. 6681-6690 ◽  
Author(s):  
Natalie Stobbe-Maicherski ◽  
Sandra Wolff ◽  
Christian Wolff ◽  
Josef Abel ◽  
Ulrich Sydlik ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Interleukin 6 ◽  
Hepatoma Cells ◽  
Receptor Expression ◽  
Oncostatin M ◽  
Dependent Manner ◽  
Aryl Hydrocarbon

scholarly journals Inflammatory Signaling and Aryl Hydrocarbon Receptor Mediate Synergistic Induction of Interleukin 6 in MCF-7 Cells

2008 ◽  
Vol 68 (10) ◽  
pp. 3609-3617 ◽  
Author(s):  
Brett D. Hollingshead ◽  
Timothy V. Beischlag ◽  
Brett C. DiNatale ◽  
Preeti Ramadoss ◽  
Gary H. Perdew
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Interleukin 6 ◽  
Inflammatory Signaling ◽  
Aryl Hydrocarbon ◽  
Synergistic Induction ◽  
Mcf 7

scholarly journals Galactomyces fermentation filtrate prevents T helper 2‐mediated reduction of filaggrin in an aryl hydrocarbon receptor‐dependent manner

2015 ◽  
Vol 40 (7) ◽  
pp. 786-793 ◽  
Author(s):  
K. Takei ◽  
C. Mitoma ◽  
A. Hashimoto‐Hachiya ◽  
M. Takahara ◽  
G. Tsuji ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Dependent Manner ◽  
T Helper ◽  
T Helper 2 ◽  
Aryl Hydrocarbon ◽  
Mediated Reduction

Estradiol regulates aryl hydrocarbon receptor expression in the rat uterus

2010 ◽  
Vol 321 (2) ◽  
pp. 253-257 ◽  
Author(s):  
Georg Kretzschmar ◽  
Anja Papke ◽  
Oliver Zierau ◽  
Frank Josef Möller ◽  
Svjetlana Medjakovic ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Expression ◽  
Rat Uterus ◽  
Aryl Hydrocarbon

scholarly journals The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases

2018 ◽  
Vol 19 (12) ◽  
pp. 3851 ◽  
Author(s):  
Drew Neavin ◽  
Duan Liu ◽  
Balmiki Ray ◽  
Richard Weinshilboum
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Nuclear Receptor ◽  
Binding Sites ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Dependent Manner ◽  
Nucleotide Polymorphisms ◽  
Aryl Hydrocarbon ◽  
Inflammatory Processes ◽  
Targeted Gene Expression

The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to environmental stimuli. It was recognized historically for its role in toxicology but, in recent decades, it has been increasingly recognized as an important modulator of disease—especially for its role in modulating immune and inflammatory responses. AHR has been implicated in many diseases that are driven by immune/inflammatory processes, including major depressive disorder, multiple sclerosis, rheumatoid arthritis, asthma, and allergic responses, among others. The mechanisms by which AHR has been suggested to impact immune/inflammatory diseases include targeted gene expression and altered immune differentiation. It has been suggested that single nucleotide polymorphisms (SNPs) that are near AHR-regulated genes may contribute to AHR-dependent disease mechanisms/pathways. Further, we have found that SNPs that are outside of nuclear receptor binding sites (i.e., outside of AHR response elements (AHREs)) may contribute to AHR-dependent gene regulation in a SNP- and ligand-dependent manner. This review will discuss the evidence and mechanisms of AHR contributions to immune/inflammatory diseases and will consider the possibility that SNPs that are outside of AHR binding sites might contribute to AHR ligand-dependent inter-individual variation in disease pathophysiology and response to pharmacotherapeutics.

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