Tofacitinib improved peripheral endothelial dysfunction and brain BDNF levels in the rat adjuvant‐induced arthritis model

2021 ◽  
Author(s):  
Perle Totoson ◽  
Celian Peyronnel ◽  
Aurore Quirié ◽  
Martin Pédard ◽  
Marina Cefis ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Arthritis Model ◽  
Adjuvant Induced Arthritis

scholarly journals AB0113 ARTHRITIS IS ASSOCIATED WITH CEREBROVASCULAR ENDOTHELIAL DYSFUNCTION: MECHANISTIC INSIGHTS IN THE RAT ADJUVANT-INDUCED ARTHRITIS MODEL

2019 ◽  
Author(s):  
Romain Bordy ◽  
Perle Totoson ◽  
Marie-Lynda Bouressam ◽  
François Dupuis ◽  
Frank Verhoeven ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Arthritis Model ◽  
Adjuvant Induced Arthritis

scholarly journals Simultaneous Determination of 5 Active Components of Periploca forrestii Schltr Extract in Rat Plasma by UPLC-MS and Its Application to Pharmacokinetic Studies in Normal and Adjuvant-Induced Arthritis Model Rats

2020 ◽  
Vol 15 (12) ◽  
pp. 1934578X2098143
Author(s):  
Hui Liu ◽  
Hao Chen ◽  
Xiaoli Qin ◽  
Xue Ma ◽  
Zipeng Gong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chlorogenic Acid ◽  
Intravenous Administration ◽  
Area Under The Curve ◽  
Pharmacokinetic Studies ◽  
Active Components ◽  
Arthritis Model ◽  
Adjuvant Induced Arthritis ◽  
Neochlorogenic Acid

Periploca forrestii Schltr ( P. forrestii) is a herb used in traditional Chinese medicine for its anti-rheumatoid arthritis effect. The aim of this study was to compare the pharmacokinetic properties of the 5 active components of this plant: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid C, and periplocin between normal rats and adjuvant-induced arthritis model rats. After the intravenous administration (177.78 mg/kg) of P. forrestii extract, samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. Compared with normal rats, the area under the curve [(AUC)(0-t), AUC(0-∞)], mean residence time [(MRT)(0-t), MRT(0-∞)] of neochlorogenic acid-treated rats decreased significantly, and drug clearance (CL) and apparent volume of distribution (V) increased significantly; the V of chlorogenic acid-treated rats decreased significantly, and MRT(0-t) significantly increased; the AUC(0-t) and AUC(0-∞) of cryptochlorogenic acid-treated rats decreased significantly, and CL and V increased significantly; the AUC(0-t) and MRT(0-t) of isochlorogenic acid C-treated rats decreased significantly, and V increased significantly; the AUC(0-t) and AUC(0-∞) of periplocin-treated rats increased significantly, and MRT(0-t), MRT(0-∞), CL, and V decreased significantly in model rats. The disease condition of rheumatoid arthritis in rats had a significant effect on the in vivo pharmacokinetics of P. forrestii after the intravenous administration.

scholarly journals Effect of newly developed S(+)-flurbiprofen plaster (SFPP) on inflammation and pain–a study on rat adjuvant-induced arthritis model

2016 ◽  
Vol 24 ◽  
pp. S504-S505
Author(s):  
M. Sugimoto ◽  
Y. Toda ◽  
M. Hori ◽  
A. Mitani ◽  
T. Ichihara ◽  
...  
Keyword(s):  
Arthritis Model ◽  
Adjuvant Induced Arthritis

Lipid-Core Nanocapsules Improved Antiedematogenic Activity of Tacrolimus in Adjuvant-Induced Arthritis Model

2016 ◽  
Vol 16 (2) ◽  
pp. 1265-1274 ◽  
Author(s):  
Rossana B. Friedrich ◽  
Karine Coradini ◽  
Francisco N. Fonseca ◽  
Silvia S. Guterres ◽  
Ruy C. R. Beck ◽  
...  
Keyword(s):  
Arthritis Model ◽  
Lipid Core ◽  
Adjuvant Induced Arthritis
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