Anti‐inflammatory effect of amitriptyline in a rat model of acetic acid‐induced colitis: the involvement of the TLR4/NF‐kB signaling pathway

2020 ◽  
Author(s):  
Pegah Dejban ◽  
Masomeh Sahraei ◽  
Mohsen Chamanara ◽  
Ahmadreza Dehpour ◽  
Amir Rashidian
Keyword(s):  
Acetic Acid ◽  
Signaling Pathway ◽  
Rat Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy

2016 ◽  
Vol 24 (5) ◽  
pp. 207-219 ◽  
Author(s):  
Amin Hasanvand ◽  
Hossein Amini-khoei ◽  
Mohammad-Reza Hadian ◽  
Alireza Abdollahi ◽  
Seyed Mohammad Tavangar ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Signaling Pathway ◽  
Rat Model ◽  
Ampk Signaling ◽  
Anti Inflammatory ◽  
Inflammatory Effect

W1706 Anti-Inflammatory Effect of Vagus Nerve Stimulation in a Rat Model of Colitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-721
Author(s):  
Julien Meregnani ◽  
Clarençon Didier ◽  
Chloé A. Picq ◽  
Valérie Sinniger ◽  
Bruno L. Bonaz
Keyword(s):  
Vagus Nerve ◽  
Rat Model ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yi Xin ◽  
Qin Yuan ◽  
Chaoqi Liu ◽  
Changcheng Zhang ◽  
Ding Yuan
Keyword(s):  
Signaling Pathway ◽  
Mouse Liver ◽  
Inflammatory Responses ◽  
Biological Activities ◽  
Raw264.7 Cells ◽  
Inflammation Model ◽  
Raw264.7 Cell ◽  
Anti Inflammatory ◽  
Gsk 3Β ◽  
Inflammatory Effect

Abstract It has been demonstrated that Chikusetsusaponin IVa (CsIVa) possesses abundant biological activities. Herein, using LPS to establish acute inflammation model of mouse liver and cell line inflammation model, we investigated whether miR-155/GSK-3β regulated NF-κB signaling pathway, and CsIVa exerted anti-inflammatory effects by regulating miR-155/GSK-3β signaling pathway. Our results showed that LPS induced high expression of miR-155 and miR-155 promoted macrophage activation through GSK-3β. In addition, CsIVa inhibited inflammatory responses in LPS-induced mouse liver and RAW264.7 cells. Furthermore, we demonstrated that CsIVa improved the inflammatory response in LPS-induced RAW264.7 cells by inhibiting miR-155, increasing GSK-3β expression, and inhibiting NF-κB signaling pathway. In conclusion, our study reveals that CsIVa suppresses LPS-triggered immune response by miR-155/GSK-3β-NF-κB signaling pathway.

scholarly journals The Anti-Inflammatory Effect of Pistacia Lentiscus in a Rat Model of Colitis

2020 ◽  
Vol Volume 13 ◽  
pp. 369-376
Author(s):  
Maryam Ostovan ◽  
Seyyed Mohammad Bagher Fazljou ◽  
Hajar Khazraei ◽  
Mostafa Araj Khodaei ◽  
Mohammadli Torbati
Keyword(s):  
Rat Model ◽  
Pistacia Lentiscus ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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