The possible role of CREB‐BDNF signaling pathway in neuroprotective effects of minocycline against alcohol‐induced neurodegeneration: molecular and behavioral evidences

2021 ◽  
Author(s):  
Majid Motaghinejad ◽  
Roya Mashayekh ◽  
Manijeh Motevalian ◽  
Sepideh Safari
Keyword(s):  
Signaling Pathway ◽  
Neuroprotective Effects ◽  
Bdnf Signaling

scholarly journals EGCG Promotes Neurite Outgrowth through the Integrin β1/FAK/p38 Signaling Pathway after Subarachnoid Hemorrhage

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yuyuan Zhang ◽  
Mengguo Han ◽  
Xiaoxue Sun ◽  
Guojun Gao ◽  
Guoying Yu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Neurite Outgrowth ◽  
Signaling Pathway ◽  
Cell Injury ◽  
Integrin Β1 ◽  
Neuroprotective Effects ◽  
Neurological Score ◽  
Biological Component ◽  
Abnormal Neurites

The abnormal neurites have long been regarded as the main player contributing to the poor outcome of patients with subarachnoid hemorrhage (SAH). (-)-Eigallocatechin-3-gallate (EGCG), the major biological component of tea catechin, exhibited strong neuroprotective effects against central nervous system diseases; however, the role of EGCG-mediated neurite outgrowth after SAH has not been delineated. Here, the effect of reactive oxygen species (ROS)/integrin β1/FAK/p38 pathway on neurite outgrowth was investigated. As expected, oxyhemoglobin- (OxyHb-) induced excessive ROS level was significantly reduced by EGCG as well as antioxidant N-acetyl-l-cysteine (NAC). Consequently, the expression of integrin β1 was significantly inhibited by EGCG and NAC. Meanwhile, EGCG significantly inhibited the overexpression of phosphorylated FAK and p38 to basal level after SAH. As a result, the abnormal neurites and cell injury were rescued by EGCG, which eventually increased energy generation and neurological score after SAH. These results suggested that EGCG promoted neurite outgrowth after SAH by inhibition of ROS/integrin β1/FAK/p38 signaling pathway. Therefore, EGCG might be a new pharmacological agent that targets neurite outgrowth in SAH therapy.

scholarly journals Preventive effects of duloxetine against methamphetamine induced neurodegeneration and motor activity disorder in rat: Possible role of CREB/BDNF signaling pathway

2019 ◽  
Vol 10 (1) ◽  
pp. 195
Author(s):  
Manijeh Motevalian ◽  
Niloofar Mohammadi ◽  
Parastoo Taheri ◽  
Elaheh Shahmoradi ◽  
Majid Motaghinejad ◽  
...  
Keyword(s):  
Motor Activity ◽  
Signaling Pathway ◽  
Bdnf Signaling ◽  
Preventive Effects

scholarly journals Crocin acts as a neuroprotective mediator against methylphenidate-induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway

2020 ◽  
Vol 79 (4) ◽  
pp. 352-366
Author(s):  
Andia Ebrahimzadeh ◽  
Sara Yousefi Moghadam ◽  
Hanieh Rahimi ◽  
Majid Motaghinejad ◽  
Manijeh Motevalian ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Bdnf Signaling

scholarly journals The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway

2014 ◽  
Vol 15 (2) ◽  
pp. 3234-3252 ◽  
Author(s):  
Dong Lin ◽  
Ike De La Pena ◽  
Lili Lin ◽  
Shu-Feng Zhou ◽  
Cesar Borlongan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Bdnf Signaling
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