Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective

2019 ◽  
Vol 33 (5) ◽  
pp. 524-526
Author(s):  
Fabrice Antigny
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Smooth Muscle

scholarly journals The Functional Availability of Arterial Kv7 Channels Is Suppressed Considerably by Large-Conductance Calcium-Activated Potassium Channels in 2- to 3-Month Old but Not in 10- to 15-Day Old Rats

2020 ◽  
Vol 11 ◽  
Author(s):  
Dongyu Ma ◽  
Dina Gaynullina ◽  
Nadine Schmidt ◽  
Mitko Mladenov ◽  
Rudolf Schubert
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Smooth Muscle ◽  
Bk Channels ◽  
Similar Degree ◽  
Functional Impact ◽  
Adult Rat ◽  
Kv7 Channels ◽  
Contractile Effect ◽  
Arterial Contractility

BackgroundVoltage-gated potassium (Kv) channels, especially Kv7 channels, are major potassium channels identified in vascular smooth muscle cells with a great, albeit differential functional impact in various vessels. Vascular smooth muscle Kv7 channels always coexist with other K channels, in particular with BK channels. BK channels differ in the extent to which they influence vascular contractility. Whether this difference also causes the variability in the functional impact of Kv7 channels is unknown. Therefore, this study addressed the hypothesis that the functional impact of Kv7 channels depends on BK channels.Experimental ApproachExperiments were performed on young and adult rat gracilis and saphenous arteries using real-time PCR as well as pressure and wire myography.Key ResultsSeveral subfamily members of Kv7 (KCNQ) and BK channels were expressed in saphenous and gracilis arteries: the highest expression was observed for BKα, BKβ1 and KCNQ4. Arterial contractility was assessed with methoxamine-induced contractions and pressure-induced myogenic responses. In vessels of adult rats, inhibition of Kv7 channels or BK channels by XE991 or IBTX, respectively enhanced arterial contractility to a similar degree, whereas activation of Kv7 channels or BK channels by retigabine or NS19504, respectively reduced arterial contractility to a similar degree. Further, IBTX increased both the contractile effect of XE991 and the anticontractile effect of retigabine, whereas NS19504 reduced the effect of retigabine and impaired the effect of XE991. In vessels of young rats, inhibition of Kv7 channels by XE991 enhanced arterial contractility much stronger than inhibition of BK channels by IBTX, whereas activation of Kv7 by retigabine reduced arterial contractility to a greater extent than activation of BK channels by NS19504. Further, IBTX increased the anticontractile effect of retigabine but not the contractile effect of XE991, whereas NS19504 reduced the effect of retigabine and impaired the effect of XE991.ConclusionKv7 and BK channels are expressed in young and adult rat arteries and function as negative feedback modulators in the regulation of contractility of these arteries. Importantly, BK channels govern the extent of functional impact of Kv7 channels. This effect depends on the relationship between the functional activities of BK and Kv7 channels.

scholarly journals Sodium‐activated potassium channels moderate excitability in vascular smooth muscle

2019 ◽  
Vol 597 (20) ◽  
pp. 5093-5108 ◽  
Author(s):  
Ping Li ◽  
Carmen M. Halabi ◽  
Richard Stewart ◽  
Alice Butler ◽  
Bobbie Brown ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Smooth Muscle

scholarly journals The Vasorelaxant Effect ofp-Cymene in Rat Aorta Involves Potassium Channels

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Martapolyana T. M. Silva ◽  
Fernanda P. R. A. Ribeiro ◽  
Maria Alice M. B. Medeiros ◽  
Pedrita A. Sampaio ◽  
Yonara M. S. Silva ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Smooth Muscle ◽  
Channel Blocker ◽  
Antimicrobial Activities ◽  
Rat Aorta ◽  
Relaxant Effect ◽  
Vasorelaxant Effect ◽  
Dose Dependent ◽  
Relaxing Effect

The monoterpenes are the main constituents of most essential oils andp-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However, there is no report concerning its pharmacological activity on the vascular smooth muscle. The aim of current work was to investigate the effects ofp-cymene in isolated rat aorta and also study its mechanism of action. In this work, we show thatp-cymene has a relaxant effect, in a dose-dependent way, on the vascular smooth muscle, regardless of the presence of the endothelium. Using a nonselective potassium channel blocker, the CsCl, the relaxant effect ofp-cymene was attenuated. In the presence of more selective potassium channels blockers, such as TEA or 4-AP, no change in the relaxant effect ofp-cymene was evidenced, indicating thatBKCaandKVchannels are not involved in that relaxant effect. However, in the presence of glibenclamide or BaCl2,KATPandKirblockers, respectively, the relaxant effect ofp-cymene was attenuated. The data presented indicate thatp-cymene has a relaxing effect on rat aorta, regardless of the endothelium, but with the participation of theKATPandKirchannels.

scholarly journals The phytoestrogen ginsensoside Re activates potassium channels of vascular smooth muscle cells through PI3K/Akt and nitric oxide pathways

2007 ◽  
Vol 54 (3,4) ◽  
pp. 381-384 ◽  
Author(s):  
Yutaka Nakaya ◽  
Kazuaki Mawatari ◽  
Akira Takahashi ◽  
Nagakatsu Harada ◽  
Akiko Hata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells

Sirolimus Causes Relaxation of Human Vascular Smooth Muscle: A Novel Action of Sirolimus Mediated via ATP-Sensitive Potassium Channels

2006 ◽  
Vol 320 (3) ◽  
pp. 1204-1208 ◽  
Author(s):  
Srinivas Ghatta ◽  
Radhika R. Tunstall ◽  
Sohail Kareem ◽  
Mohamed Rahman ◽  
Stephen T. O'Rourke
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Smooth Muscle

ATP‐sensitive potassium channels in zebrafish cardiac and vascular smooth muscle

2021 ◽  
Author(s):  
Soma S. Singareddy ◽  
Helen I. Roessler ◽  
Conor McClenaghan ◽  
Jen Ikle ◽  
Rob Tryon ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channels ◽  
Vascular Smooth Muscle
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