Felbamate produces antidepressant‐like actions in the chronic unpredictable mild stress and chronic social defeat stress models of depression

2019 ◽  
Vol 33 (6) ◽  
pp. 621-633 ◽  
Author(s):  
Xiuqin Li ◽  
Hongze Wang ◽  
Qingnian Chen ◽  
Zhiqin Li ◽  
Chao Liu ◽  
...  
Keyword(s):  
Social Defeat ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress ◽  
Stress Models

scholarly journals LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice

2020 ◽  
Vol 23 (12) ◽  
pp. 821-836
Author(s):  
Ting-Ting Gao ◽  
Yuan Wang ◽  
Ling Liu ◽  
Jin-Liang Wang ◽  
Ying-Jie Wang ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Restraint Stress ◽  
Social Defeat ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Chronic Restraint Stress ◽  
Lim Domain ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress ◽  
Pharmacological Target

Abstract Background Depression is one of the most common forms of mental illness and also a leading cause of disability worldwide. Developing novel antidepressant targets beyond the monoaminergic systems is now popular and necessary. LIM kinases, including LIM domain kinase 1 and 2 (LIMK1/2), play a key role in actin and microtubule dynamics through phosphorylating cofilin. Since depression is associated with atrophy of neurons and reduced connectivity, here we speculate that LIMK1/2 may play a role in the pathogenesis of depression. Methods In this study, the chronic unpredictable mild stress (CUMS), chronic restraint stress (CRS), and chronic social defeat stress (CSDS) models of depression, various behavioral tests, stereotactic injection, western blotting, and immunofluorescence methods were adopted. Results CUMS, CRS, and CSDS all significantly enhanced the phosphorylation levels of LIMK1 and LIMK2 in the medial prefrontal cortex (mPFC) but not the hippocampus of mice. Administration of fluoxetine, the most commonly used selective serotonin reuptake inhibitor in clinical practice, fully reversed the effects of CUMS, CRS, and CSDS on LIMK1 and LIMK2 in the mPFC. Moreover, pharmacological inhibition of LIMK1 and LIMK2 in the mPFC by LIMKi 3 infusions notably prevented the pro-depressant effects of CUMS, CRS, and CSDS in mice. Conclusions In summary, these results suggest that LIMK1/2 in the mPFC has a role in chronic stress-induced depressive-like effects in mice and could be a novel pharmacological target for developing antidepressants.

scholarly journals Brain histamine and oleoylethanolamide restore behavioral deficits induced by chronic social defeat stress in mice

2021 ◽  
pp. 100317
Author(s):  
Barbara Rani ◽  
Andrea Santangelo ◽  
Adele Romano ◽  
Justyna Barbara Koczwara ◽  
Marzia Friuli ◽  
...  
Keyword(s):  
Social Defeat ◽  
Social Defeat Stress ◽  
Behavioral Deficits ◽  
Brain Histamine ◽  
Chronic Social Defeat Stress

scholarly journals Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 252
Author(s):  
Tatiana A. Gudasheva ◽  
Anna V. Tallerova ◽  
Armen G. Mezhlumyan ◽  
Tatyana A. Antipova ◽  
Ilya O. Logvinov ◽  
...  
Keyword(s):  
Dose Range ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
In Vivo Experiments ◽  
Trk Receptor ◽  
Chronic Social Defeat Stress ◽  
Swimming Test ◽  
Scientific Group

A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments. In vivo experiments with rodents revealed its antidepressant-like activity in the forced swim and the tail suspension tests at the dose range of 0.1–5.0 mg/kg (i.p., p.o.). However, GSB-106 was not studied in depression models modulating major depression in humans. In the present study, the GSB-106 antidepressant-like activity was revealed in mice at the depression model induced by 28-day social defeat stress with 21-days oral administration (0.1 mg/kg) after stress. At the same time, GSB-106 restored reduced locomotor activity and completely eliminated the anhedonia manifestations. The compound also restored reduced levels of synaptophysin and CREB in the hippocampus. In addition, the Trk receptor antagonist K252A, and the PLC inhibitor U73122, were found to completely block the antidepressant-like activity of GSB-106 in the forced swimming test in mice. Thus, the present results demonstrate the dipeptide BDNF mimetic GSB-106 reversed depressive-like behavior and restored hippocampal neuroplasticity in a rodent depression model. These effects of GSB-106 are probably regulated by TrkB signaling.

scholarly journals Chronic social defeat stress disrupts regulation of lipid synthesis

2010 ◽  
Vol 51 (6) ◽  
pp. 1344-1353 ◽  
Author(s):  
Jen-Chieh Chuang ◽  
Huxing Cui ◽  
Brittany L. Mason ◽  
Melissa Mahgoub ◽  
Angie L. Bookout ◽  
...  
Keyword(s):  
Lipid Synthesis ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress

scholarly journals JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

2018 ◽  
Vol 44 (4) ◽  
pp. 683-694 ◽  
Author(s):  
Xiaolei Zhu ◽  
Michael T. Nedelcovych ◽  
Ajit G. Thomas ◽  
Yuto Hasegawa ◽  
Aisa Moreno-Megui ◽  
...  
Keyword(s):  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress ◽  
Glutaminase Activity

Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome

2018 ◽  
Vol 34 (1) ◽  
pp. 319-329 ◽  
Author(s):  
Wenqi Gao ◽  
Wei Wang ◽  
Gang Liu ◽  
Jing Zhang ◽  
Jian Yang ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress
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