Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice

2017 ◽  
Vol 31 (4) ◽  
pp. 403-410 ◽  
Author(s):  
Kausar Jahan ◽  
Krishna K. Pillai ◽  
Divya Vohora
Keyword(s):  
Brain Neurotransmitters ◽  
Psychomotor Seizure ◽  
Seizure Model

scholarly journals Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model – an isobolographic analysis

2015 ◽  
Vol 26 (1) ◽  
pp. 82-87
Keyword(s):  
Dose Response ◽  
Seizure Activity ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Additive Interaction ◽  
Isobolographic Analysis ◽  
Psychomotor Seizure ◽  
Seizure Model ◽  
A Current ◽  
Anticonvulsant Effects

The aim of this study was to characterize the anticonvulsant effects of levetiracetam (LEV) in combination with lamotrigine (LTG – a second-generation antiepileptic drug), in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to characterize the consequent anticonvulsant interactions between the drug combinations. Results indicated that LEV administered singly was associated with a DRRC that was parallel to that for LTG. With isobolography for parallel DRRCs, the combination of LEV with LTG at three fixed-ratios of 1:3, 1:1 and 3:1 exerted additive interaction. LEV combined with LTG exerted additive interaction in the mouse 6 Hz psychomotor seizure model.

Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

2001 ◽  
Vol 47 (3) ◽  
pp. 217-227 ◽  
Author(s):  
Matthew E. Barton ◽  
Brian D. Klein ◽  
Harold H. Wolf ◽  
H. Steve White
Keyword(s):  
Partial Epilepsy ◽  
Pharmacological Characterization ◽  
Psychomotor Seizure ◽  
Seizure Model

scholarly journals Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

2015 ◽  
Vol 28 (3) ◽  
pp. 204-207 ◽  
Author(s):  
Aleksandra Wlaz ◽  
Maria W. Kondrat-Wrobel ◽  
Katarzyna Zaluska ◽  
Ewelina Kochman ◽  
Anna R. Rekas ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Stimulus Duration ◽  
Synergistic Interaction ◽  
Type Ii ◽  
Isobolographic Analysis ◽  
Swiss Mice ◽  
Psychomotor Seizure ◽  
Seizure Model ◽  
A Current ◽  
Anticonvulsant Effects

Abstract This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.

Influence of caffeine on the protective potency of antiepileptic drugs in the 6Hz psychomotor seizure model in mice

2010 ◽  
Vol 62 ◽  
pp. 38-39
Author(s):  
Magdalena Chrościńska-Krawczyk ◽  
Magdalena Wałek ◽  
Bożydar Tylus ◽  
Stanisław J. Czuczwar
Keyword(s):  
Antiepileptic Drugs ◽  
Psychomotor Seizure ◽  
Seizure Model
Sign in / Sign up

Export Citation Format

Share Document