Inhibition of transient receptor potential vanilloid-1 confers neuroprotection, reduces tumor necrosis factor-alpha, and increases IL-10 in a rat stroke model

2017 ◽  
Vol 31 (4) ◽  
pp. 420-428 ◽  
Author(s):  
Elham Hakimizadeh ◽  
Ali Shamsizadeh ◽  
Ali Roohbakhsh ◽  
Mohammad Kazemi Arababadi ◽  
Mohammad R. Hajizadeh ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Stroke Model ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Transient Receptor ◽  
Necrosis Factor

scholarly journals Immediate and delayed potentiating effects of tumor necrosis factor-α on TRPV1 sensitivity of rat vagal pulmonary sensory neurons

2017 ◽  
Vol 313 (2) ◽  
pp. L293-L304 ◽  
Author(s):  
Chun-Chun Hsu ◽  
You Shuei Lin ◽  
Ruei-Lung Lin ◽  
Lu-Yuan Lee
Keyword(s):  
Tumor Necrosis Factor ◽  
Sensory Neurons ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Cox 2 ◽  
Factor Α ◽  
Necrosis Factor

We studied acute effects of tumor necrosis factor-α (TNFα) on the sensitivity of isolated rat vagal pulmonary sensory neurons. Our results showed the following. First, a brief pretreatment with a low dose of TNFα (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Δ = 247%) immediately following the TNFα pretreatment, which gradually declined toward control and then increased again reaching another peak (Δ = 384%) after 60–90 min. Second, the immediate phase of this potentiating effect of TNFα was completely abolished by a pretreatment with a selective cyclooxygenase-2 (COX-2) inhibitor, NS-398, whereas the delayed potentiation was only partially attenuated. Third, in sharp contrast, TNFα did not generate any potentiating effect on the responses to non-TRPV1 chemical activators of these neurons. Fourth, the selectivity of the TNFα action on TRPV1 was further illustrated by the responses to acid (pH 6.0); TNFα did not affect the rapid transient current mediated by acid-sensing ion channels but significantly augmented the slow sustained current mediated by TRPV1 in the same neurons. Fifth, in anesthetized rats, a similar pattern of acute sensitizing effects of TNFα on pulmonary C-fiber afferents and the involvement of COX-2 were also clearly shown. In conclusion, a brief pretreatment with TNFα induced both immediate and delayed potentiating effects on the TRPV1 sensitivity in pulmonary sensory neurons, and the production of COX-2 arachidonic acid metabolites plays a major role in the immediate sensitizing effect of TNFα.

The crosstalk between Nodal and Tumor Necrosis factor alpha during luteolysis establishment in the mare

2016 ◽  
Author(s):  
Antonio Galvao ◽  
Joanna Staszkiewicz ◽  
Karolina Thomas ◽  
Maria Rebordao ◽  
Dariusz Skarzynski ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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