Transglutaminase 2 mediates UVB‐induced matrix metalloproteinase‐1 expression by inhibiting nuclear p65 degradation in dermal fibroblasts

2021 ◽  
Author(s):  
Seok‐Jin Lee ◽  
Ki Baek Lee ◽  
Ah‐Young Hong ◽  
Young Hoon Son ◽  
Dong Hun Lee ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Transglutaminase 2 ◽  
Dermal Fibroblasts ◽  
Matrix Metalloproteinase 1

scholarly journals Inhibitory Effect of Opuntia humifusa Fruit Water Extract on Solar Ultraviolet-Induced MMP-1 Expression

2018 ◽  
Vol 19 (9) ◽  
pp. 2503 ◽  
Author(s):  
Ah-Ram Han ◽  
Tae-Gyu Lim ◽  
Young-Ran Song ◽  
Mi Jang ◽  
Young Rhee ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Radical Scavenging ◽  
Water Extract ◽  
Inhibitory Effect ◽  
Dermal Fibroblasts ◽  
Ros Generation ◽  
Skin Damage ◽  
Opuntia Humifusa ◽  
Matrix Metalloproteinase 1 ◽  
Solar Ultraviolet

Opuntia humifusa is a type of cactus whose fruits have been used in folk medicine for the treatment of several diseases. In the present study, we aimed to determine whether O. humifusa fruit water extract (OHE) has inhibitory effects against solar ultraviolet (sUV)-induced matrix metalloproteinase-1 (MMP-1) expression. In ex vivo human skin, we found that OHE suppressed sUV radiation-induced MMP-1 expression. The inhibitory effect of OHE was confirmed in human dermal fibroblasts. OHE treatment reduced sUV-induced MMP-1 expression by suppressing reactive oxygen species (ROS) generation and phosphorylation of c-Jun, a component of transcription factor activator protein 1 (AP-1). On the other hand, OHE recovered the tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) and type 1 collagen production attenuated by sUV. As upstream signaling pathways for AP-1, MKK4-JNK, MEK-ERK, and MKK3/6-p38 phosphorylation were downregulated by OHE treatment. In addition, OHE exhibited DPPH radical scavenging activity. These findings demonstrate that OHE has a preventive effect against sUV-induced skin damage via suppression of pathways triggered by ROS.

scholarly journals Kynurenine Increases Matrix Metalloproteinase-1 and -3 Expression in Cultured Dermal Fibroblasts and Improves Scarring In Vivo

2014 ◽  
Vol 134 (3) ◽  
pp. 643-650 ◽  
Author(s):  
Yunyuan Li ◽  
Ruhangiz T. Kilani ◽  
Elham Rahmani-Neishaboor ◽  
Reza B. Jalili ◽  
Aziz Ghahary
Keyword(s):  
Matrix Metalloproteinase ◽  
Dermal Fibroblasts ◽  
Matrix Metalloproteinase 1
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