scholarly journals The Role of PI3’‐Lipid Signaling in Melanoma Initiation, Progression and Maintenance

2021 ◽  
Author(s):  
Gennie L. Parkman ◽  
Mona Foth ◽  
David A. Kircher ◽  
Sheri L. Holmen ◽  
Martin McMahon
Keyword(s):  
Lipid Signaling

The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease: A Comprehensive View

2018 ◽  
Vol 15 (13) ◽  
pp. 1191-1212 ◽  
Author(s):  
Botond Penke ◽  
Gábor Paragi ◽  
János Gera ◽  
Róbert Berkecz ◽  
Zsolt Kovács ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Signaling Pathways ◽  
Membrane Lipids ◽  
Specific Protein ◽  
Dietary Factors ◽  
Lipid Signaling ◽  
Special Role ◽  
Aβ Peptides

Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer’s disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids to AD. In addition, lipid signaling pathways have a crucial role in the cellular homeostasis and depend on specific protein-lipid interactions. The current review focuses on pathological alterations of membrane lipids (cholesterol, glycerophospholipids, sphingolipids) and lipid metabolism in AD and provides insight in the current understanding of biological membranes, their lipid structures and functions, as well as their role as potential therapeutic targets. Novel methods for studying the membrane structure and lipid composition will be reviewed in a broad sense whereas the use of lipid biomarkers for early diagnosis of AD will be shortly summarized. Interactions of Aβ peptides with the cell membrane and different subcellular organelles are reviewed. Next, the details of the most important lipid signaling pathways, including the role of the plasma membrane as stress sensor and its therapeutic applications are given. 4-hydroxy-2-nonenal may play a special role in the initiation of the pathogenesis of AD and thus the “calpain-cathepsin hypothesis” of AD is highlighted. Finally, the most important lipid dietary factors and their possible use and efficacy in the prevention of AD are discussed.

The role of lipid signaling in constitutive membrane traffic

1997 ◽  
Vol 9 (4) ◽  
pp. 519-526 ◽  
Author(s):  
Michael G Roth ◽  
Paul C Sternweis
Keyword(s):  
Membrane Traffic ◽  
Lipid Signaling

scholarly journals The Emerging Roles of Diacylglycerol Kinase (DGK) in Plant Stress Tolerance, Growth, and Development

Agronomy ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1375
Author(s):  
Idrice Carther Kue Foka ◽  
Toi Ketehouli ◽  
Yonggang Zhou ◽  
Xiao-Wei Li ◽  
Fa-Wei Wang ◽  
...  
Keyword(s):  
Plant Stress ◽  
Diacylglycerol Kinase ◽  
Lipid Signaling ◽  
Operational Mode ◽  
Biotic And Abiotic Stress ◽  
Animal Physiology ◽  
Abiotic Stressors ◽  
Key Enzyme ◽  
External Stresses

Diacylglycerol kinase (DGK) is recognized as the key enzyme of the lipid signaling pathway, which involves the transduction of messages from hormones, neurotransmitters, and immunologic and growth factors. Regarding their essential role in animal physiology, many plant biologists have predicted a similar enzymatic influence in plants. However, a small number of recent studies have revealed the complexity of the involvement of DGK genes in the modulation of plant growth, development, and adaptation in both biotic and abiotic stress conditions. Here, we describe recent discoveries on the role of DGK genes in the plants’ responses to biotic or abiotic stressors. Moreover, we discuss how DGK enzymes regulate plant cellular activities during the adaptation of plants to a readily changing environment. DGK is an enzyme that plays a pivotal role in plant lipid signaling, by catalyzing the phosphorylation of the diacylglycerol (DAG) to phosphatidic acid (PA), which is a crucial molecule in a plant’s metabolic network, leading to its response to various external stresses. DGK enzymes are the principal moderators of PA generation in plant cells; this consequently affects its derived products—hence, enabling their activities in lipid signaling networks and cell homeostasis. Thus, understanding the DGK operational mode and interactions between the production and accumulation of PA would constitute a significant advancement in investigating the mechanism of stress adaptation in plants.

Inflammation and Cancer: The Role of Lipid Signaling in the Continuum Between Two Ends of the Tumor Spectrum

2017 ◽  
pp. 167-193 ◽  
Author(s):  
Megan L. Sulciner ◽  
Molly M. Gilligan ◽  
Bruce R. Zetter ◽  
Dipak Panigrahy
Keyword(s):  
Lipid Signaling ◽  
Tumor Spectrum ◽  
The Continuum

Nuclear Lipid Signaling: Novel Role of Eicosanoids

2001 ◽  
Vol 226 (1) ◽  
pp. 1-4 ◽  
Author(s):  
R. Stewart Gilmour ◽  
Murray D. Mitchell
Keyword(s):  
Lipid Signaling

The role of lipid signaling in the progression of malignant melanoma

2018 ◽  
Vol 37 (2-3) ◽  
pp. 245-255 ◽  
Author(s):  
József Tímár ◽  
B. Hegedüs ◽  
E. Rásó
Keyword(s):  
Malignant Melanoma ◽  
Lipid Signaling

C025 Role of lipid signaling pathways in the response to erythropoietin in low risk MDS patients

2009 ◽  
Vol 33 ◽  
pp. S46
Author(s):  
C. Finell ◽  
M. Follo ◽  
S. Mongiorgi ◽  
C. Clissa ◽  
F. Chiarini ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Low Risk ◽  
Lipid Signaling
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