The Role of the Skin Microbiota in the Modulation of Cutaneous Inflammation‐ Lessons from the Gut

2021 ◽  
Author(s):  
Abigail E. Elias ◽  
Andrew J. McBain ◽  
Catherine A. O’Neill
Keyword(s):  
Skin Microbiota ◽  
Cutaneous Inflammation

scholarly journals Staphylococcal Communities on Skin Are Associated with Atopic Dermatitis and Disease Severity

2021 ◽  
Vol 9 (2) ◽  
pp. 432
Author(s):  
Sofie Marie Edslev ◽  
Caroline Meyer Olesen ◽  
Line Brok Nørreslet ◽  
Anna Cäcilia Ingham ◽  
Søren Iversen ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Alpha Diversity ◽  
Skin Microbiota ◽  
Specific Primers ◽  
Staphylococcus Lugdunensis ◽  
Disease Symptoms ◽  
Lesional Skin ◽  
Staphylococcus Capitis ◽  
Staphylococcus Hominis

The skin microbiota of atopic dermatitis (AD) patients is characterized by increased Staphylococcus aureus colonization, which exacerbates disease symptoms and has been linked to reduced bacterial diversity. Skin bacterial communities in AD patients have mostly been described at family and genus levels, while species-level characterization has been limited. In this study, we investigated the role of the bacteria belonging to the Staphylococcus genus using targeted sequencing of the tuf gene with genus-specific primers. We compared staphylococcal communities on lesional and non-lesional skin of AD patients, as well as AD patients with healthy controls, and determined the absolute abundance of bacteria present at each site. We observed that the staphylococcal community, bacterial alpha diversity, and bacterial densities were similar on lesional and non-lesional skin, whereas AD severity was associated with significant changes in staphylococcal composition. Increased S. aureus, Staphylococcus capitis, and Staphylococcus lugdunensis abundances were correlated with increased severity. Conversely, Staphylococcus hominis abundance was negatively correlated with severity. Furthermore, S. hominis relative abundance was reduced on AD skin compared to healthy skin. In conclusion, various staphylococcal species appear to be important for skin health.

scholarly journals The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in the p38/TNF-α Pathway of Systemic and Cutaneous Inflammation

2010 ◽  
Vol 130 (2) ◽  
pp. 481-491 ◽  
Author(s):  
Arndt J. Schottelius ◽  
Ulrich Zügel ◽  
Wolf-Dietrich Döcke ◽  
Thomas M. Zollner ◽  
Lars Röse ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Cutaneous Inflammation ◽  
Tnf Α ◽  
Mitogen Activated Protein

scholarly journals Microbiota in Healthy Skin and in Atopic Eczema

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Giuseppe Baviera ◽  
Maria Chiara Leoni ◽  
Lucetta Capra ◽  
Francesca Cipriani ◽  
Giorgio Longo ◽  
...  
Keyword(s):  
Atopic Eczema ◽  
Inflammatory Diseases ◽  
Normal Skin ◽  
Innate Immune ◽  
Microbiota Composition ◽  
Healthy Skin ◽  
Skin Microbiota ◽  
Disease States ◽  
The Relationship

The Italian interest group (IG) on atopic eczema and urticaria is member of the Italian Society of Allergology and Immunology. The aim of our IG is to provide a platform for scientists, clinicians, and experts. In this review we discuss the role of skin microbiota not only in healthy skin but also in skin suffering from atopic dermatitis (AD). A Medline and Embase search was conducted for studies evaluating the role of skin microbiota. We examine microbiota composition and its development within days after birth; we describe the role of specific groups of microorganisms that colonize distinct anatomical niches and the biology and clinical relevance of antimicrobial peptides expressed in the skin. Specific AD disease states are characterized by concurrent and anticorrelated shifts in microbial diversity and proportion ofStaphylococcus. These organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic microbes. These findings reveal links between microbial communities and inflammatory diseases such as AD and provide novel insights into global shifts of bacteria relevant to disease progression and treatment. This review also highlights recent observations on the importance of innate immune systems and the relationship with normal skin microflora for the maintenance of healthy skin.

scholarly journals The role of CD44 in cutaneous inflammation

2009 ◽  
Vol 18 (11) ◽  
pp. 962-968 ◽  
Author(s):  
Mona Man ◽  
Peter M. Elias ◽  
Wenyan Man ◽  
Yan Wu ◽  
Lilly Y. W. Bourguignon ◽  
...  
Keyword(s):  
Cutaneous Inflammation

Proinflammatory role of proteinase‐activated receptor‐2 in humans and mice during cutaneous inflammation in vivo

2003 ◽  
Vol 17 (13) ◽  
pp. 1871-1885 ◽  
Author(s):  
Stephan Seeliger ◽  
Claudia K. Derian ◽  
Nathalie Vergnolle ◽  
Nigel W. Bunnett ◽  
Roman Nawroth ◽  
...  
Keyword(s):  
Cutaneous Inflammation ◽  
Proinflammatory Role

The Role of Adhesion Molecules in Cutaneous Inflammation

1994 ◽  
Vol 21 (11) ◽  
pp. 790-794 ◽  
Author(s):  
Thomas J. Lawley ◽  
S. Wright Caughman ◽  
Robert A. Swerlick ◽  
Yuelin Xu
Keyword(s):  
Adhesion Molecules ◽  
Cutaneous Inflammation

The role of mast cells in atrial natriuretic peptide-induced cutaneous inflammation

2011 ◽  
Vol 167 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Ok Hee Chai ◽  
Eui-Hyeog Han ◽  
Yun Ho Choi ◽  
Suhn Hee Kim ◽  
Hyoung Tae Kim ◽  
...  
Keyword(s):  
Mast Cells ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cutaneous Inflammation ◽  
Atrial Natriuretic
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