Itch intensity in prurigo nodularis is closely related to dermal interleukin‐31, oncostatin M, IL‐31 receptor alpha and oncostatin M receptor beta

2021 ◽  
Author(s):  
Takashi Hashimoto ◽  
Leigh A. Nattkemper ◽  
Hei Sung Kim ◽  
Christina D. Kursewicz ◽  
Emilie Fowler ◽  
...  
Keyword(s):  
Oncostatin M ◽  
Prurigo Nodularis ◽  
Receptor Alpha ◽  
Oncostatin M Receptor ◽  
Receptor Beta

scholarly journals 202 The Oncostatin M receptor beta axis identified in prurigo nodularis

2019 ◽  
Vol 139 (5) ◽  
pp. S35
Author(s):  
Z. Mikhak ◽  
S. Ständer ◽  
D. Metze ◽  
G. Yosipovitch ◽  
J. Silverberg ◽  
...  
Keyword(s):  
Oncostatin M ◽  
Prurigo Nodularis ◽  
Oncostatin M Receptor ◽  
Receptor Beta

scholarly journals 560 KPL-716, anti-Oncostatin M receptor beta antibody, reduced pruritus in atopic dermatitis

2019 ◽  
Vol 139 (5) ◽  
pp. S96 ◽  
Author(s):  
Z. Mikhak ◽  
R. Bissonnette ◽  
D. Siri ◽  
S.K. Tyring ◽  
E. Tessari ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oncostatin M ◽  
Oncostatin M Receptor ◽  
Receptor Beta

scholarly journals Overexpression of a splice variant of oncostatin M receptor beta in human esophageal squamous carcinoma

2011 ◽  
Vol 34 (3) ◽  
pp. 177-187 ◽  
Author(s):  
Tasneem Kausar ◽  
Rinu Sharma ◽  
Md. Raghibul Hasan ◽  
Anoop Saraya ◽  
Tushar K. Chattopadhyay ◽  
...  
Keyword(s):  
Splice Variant ◽  
Squamous Carcinoma ◽  
Oncostatin M ◽  
Esophageal Squamous Carcinoma ◽  
Oncostatin M Receptor ◽  
Receptor Beta

scholarly journals Interleukin-31 and Pruritic Skin

2021 ◽  
Vol 10 (9) ◽  
pp. 1906
Author(s):  
Masutaka Furue ◽  
Mihoko Furue
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Subjective Symptom ◽  
Oncostatin M ◽  
Inflammatory Skin Diseases ◽  
Prurigo Nodularis ◽  
T Helper 2 ◽  
Oncostatin M Receptor ◽  
Pruritic Skin

Skin inflammation often evokes pruritus, which is the major subjective symptom in many inflammatory skin diseases such as atopic dermatitis and prurigo nodularis. Pruritus or itch is a specific sensation found only in the skin. Recent studies have stressed the pivotal role played by interleukin-31 (IL-31) in the sensation of pruritus. IL-31 is produced by various cells including T helper 2 cells, macrophages, dendritic cells and eosinophils. IL-31 signals via a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor β. Recent clinical trials have shown that the anti-IL-31RA antibody nemolizumab can successfully decrease pruritus in patients with atopic dermatitis and prurigo nodularis. The IL-31 pathway and pruritic skin are highlighted in this review article.

scholarly journals The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling

2021 ◽  
Vol 22 (8) ◽  
pp. 3831
Author(s):  
Tiziana Bachetti ◽  
Francesca Rosamilia ◽  
Martina Bartolucci ◽  
Giuseppe Santamaria ◽  
Manuela Mosconi ◽  
...  
Keyword(s):  
Immune Response ◽  
Oncostatin M ◽  
Common Life ◽  
Downstream Signaling ◽  
Whole Exome ◽  
Gut Homeostasis ◽  
Life Threatening ◽  
Infection And Inflammation ◽  
Susceptibility Variant ◽  
Oncostatin M Receptor

Hirschsprung (HSCR) Associated Enterocolitis (HAEC) is a common life-threatening complication in HSCR. HAEC is suggested to be due to a loss of gut homeostasis caused by impairment of immune system, barrier defense, and microbiome, likely related to genetic causes. No gene has been claimed to contribute to HAEC occurrence, yet. Genetic investigation of HAEC by Whole-Exome Sequencing (WES) on 24 HSCR patients affected (HAEC) or not affected (HSCR-only) by enterocolitis and replication of results on a larger panel of patients allowed the identification of the HAEC susceptibility variant p.H187Q in the Oncostatin-M receptor (OSMR) gene (14.6% in HAEC and 5.1% in HSCR-only, p = 0.0024). Proteomic analysis on the lymphoblastoid cell lines from one HAEC patient homozygote for this variant and one HAEC patient not carrying the variant revealed two well distinct clusters of proteins significantly up or downregulated upon OSM stimulation. A marked enrichment in immune response pathways (q < 0.0001) was shown in the HAEC H187 cell line, while proteins upregulated in the HAEC Q187 lymphoblasts sustained pathways likely involved in pathogen infection and inflammation. In conclusion, OSMR p.H187Q is an HAEC susceptibility variant and perturbates the downstream signaling cascade necessary for the gut immune response and homeostasis maintenance.

Activation of Oncostatin M Receptor-β in Cardiomyocytes Increases Serum Levels of FGF23 During Heart Failure

2015 ◽  
Vol 34 (4) ◽  
pp. S174
Author(s):  
M.H. Richter ◽  
H. Lautze ◽  
W. Skwara ◽  
M. Schönburg ◽  
A. Beiras-Fernandez ◽  
...  
Keyword(s):  
Heart Failure ◽  
Serum Levels ◽  
Oncostatin M ◽  
Oncostatin M Receptor
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