Mouse models of atopic dermatitis: a critical reappraisal

2020 ◽  
Author(s):  
Amos Gilhar ◽  
Kristian Reich ◽  
Aviad Keren ◽  
Kenji Kabashima ◽  
Martin Steinhoff ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Models

scholarly journals Insights into atopic dermatitis gained from genetically defined mouse models

2019 ◽  
Vol 143 (1) ◽  
pp. 13-25 ◽  
Author(s):  
Saeko Nakajima ◽  
Takashi Nomura ◽  
John Common ◽  
Kenji Kabashima
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Models

scholarly journals Topical Herbal Application in the Management of Atopic Dermatitis: A Review of Animal Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Younghee Yun ◽  
Kyuseok Kim ◽  
Inhwa Choi ◽  
Seong-Gyu Ko
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Mouse Models ◽  
Animal Studies ◽  
Skin Lesions ◽  
Risk Of Bias ◽  
Asian Countries ◽  
Th2 Cell ◽  
Unclear Risk

Herbs are widely used in the treatment of atopic dermatitis (AD) in Eastern Asian countries, and certain herbs regarded have anti-inflammatory properties that can help with AD. With the goal of developing a topical herbal agent for AD, we conducted a systematic review ofin vivostudies of AD-like skin models for screening potential herbs. Searches were conducted from PubMed and EMBASE. After all, 22 studies were included for this review. We judged most of the domains of all studies to be at unclear risk of bias. Among 22 included studies, 21 herbs have been reported to reduce AD-like skin lesions in mouse models by suppressing Th2 cell response. Our findings may offer potential herbs for the topical application treatment of AD.

scholarly journals Recent Findings in Mouse Models for Human Atopic Dermatitis

2012 ◽  
Vol 61 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Akane Tanaka ◽  
Yosuke Amagai ◽  
Kumiko Oida ◽  
Hiroshi Matsuda
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Models

scholarly journals Mouse Models for Atopic Dermatitis Developed in Japan

10.5772/26084 ◽  
2012 ◽  
Author(s):  
Hiromichi Yonekawa ◽  
Toyoyuki Takada ◽  
Hiroshi Shitara ◽  
Choji Taya ◽  
Yoshibumi Matsushima ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Models

Effect of loratadine on mouse models of atopic dermatitis associated pruritus

2005 ◽  
Vol 5 (7-8) ◽  
pp. 1331-1336 ◽  
Author(s):  
Maria Alejandra Hossen ◽  
Yoko Fujii ◽  
Masami Ogawa ◽  
Miho Takubo ◽  
Tae Tsumuro ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Models

scholarly journals Translational Relevance of Mouse Models of Atopic Dermatitis

2021 ◽  
Vol 10 (4) ◽  
pp. 613
Author(s):  
Justin Choi ◽  
Nishadh Sutaria ◽  
Youkyung Sophie Roh ◽  
Zachary Bordeaux ◽  
Martin P. Alphonse ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Model ◽  
Mouse Models ◽  
Murine Model ◽  
Current Understanding ◽  
Th2 Inflammation ◽  
Selection Of

The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model’s homology with human AD necessitates a close evaluation of its distinct immunological signature.

scholarly journals Modeling Atopic Dermatitis with Increasingly Complex Mouse Models

2008 ◽  
Vol 128 (5) ◽  
pp. 1061-1064 ◽  
Author(s):  
Tiffany C. Scharschmidt ◽  
Julia A. Segre
Keyword(s):  
Atopic Dermatitis ◽  
Mouse Models
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