Itchy body: Topographical difference of itch and scratching and C Nerve fibres

2019 ◽  
Vol 28 (12) ◽  
pp. 1385-1389 ◽  
Author(s):  
Takashi Hashimoto ◽  
Gil Yosipovitch
Keyword(s):  
Nerve Fibres ◽  
Topographical Difference

scholarly journals Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 165
Author(s):  
Jamie Burgess ◽  
Bernhard Frank ◽  
Andrew Marshall ◽  
Rashaad S. Khalil ◽  
Georgios Ponirakis ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Nerve Fibre ◽  
Diabetic Peripheral Neuropathy ◽  
Point Of Care ◽  
Unmet Need ◽  
Screening Tools ◽  
Nerve Fibres ◽  
Diagnostic Laboratory ◽  
Corneal Confocal Microscopy ◽  
Small Nerve

Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2 diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations impact drastically on quality of life, contributing to the individual, societal, financial and healthcare burden of diabetes. DPN is diagnosed at a late, often pre-ulcerative stage due to a lack of early systematic screening and the endorsement of monofilament testing which identifies advanced neuropathy only. Compared to the success of the diabetic eye and kidney screening programmes there is clearly an unmet need for an objective reliable biomarker for the detection of early DPN. This article critically appraises research and clinical methods for the diagnosis or screening of early DPN. In brief, functional measures are subjective and are difficult to implement due to technical complexity. Moreover, skin biopsy is invasive, expensive and lacks diagnostic laboratory capacity. Indeed, point-of-care nerve conduction tests are convenient and easy to implement however questions are raised regarding their suitability for use in screening due to the lack of small nerve fibre evaluation. Corneal confocal microscopy (CCM) is a rapid, non-invasive, and reproducible technique to quantify small nerve fibre damage and repair which can be conducted alongside retinopathy screening. CCM identifies early sub-clinical DPN, predicts the development and allows staging of DPN severity. Automated quantification of CCM with AI has enabled enhanced unbiased quantification of small nerve fibres and potentially early diagnosis of DPN. Improved screening tools will prevent and reduce the burden of foot ulceration and amputations with the primary aim of reducing the prevalence of this common microvascular complication.

Multielectrode spiral cuff for ordered and reversed activation of nerve fibres

1993 ◽  
Vol 15 (2) ◽  
pp. 113-120 ◽  
Author(s):  
J. Rozman ◽  
B. Sovinec ◽  
M. Trlep ◽  
B. Zorko
Keyword(s):  
Nerve Fibres

Orphanin FQ/nociceptin - immunoreactive nerve fibres parallel those containing endogenous opioids in rat spinal cord

Neuroreport ◽  
1996 ◽  
Vol 7 (8) ◽  
pp. 1341-1342
Author(s):  
M. Riedl ◽  
S. Shuster ◽  
L. Vulchanova ◽  
J. Wang ◽  
H. Loh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Endogenous Opioids ◽  
Orphanin Fq ◽  
Rat Spinal Cord ◽  
Nerve Fibres
Sign in / Sign up

Export Citation Format

Share Document