Minocycline decreases Th2 chemokines from M2 macrophages: Possible mechanisms for the suppression of bullous pemphigoid by traditional bullous disease drugs

2018 ◽  
Vol 27 (11) ◽  
pp. 1268-1272 ◽  
Author(s):  
Kayo Tanita ◽  
Taku Fujimura ◽  
Yota Sato ◽  
Chunbing Lyu ◽  
Setsuya Aiba
Keyword(s):  
Bullous Pemphigoid ◽  
M2 Macrophages ◽  
Bullous Disease ◽  
Th2 Chemokines

scholarly journals Assessing the Correlation Between Autoimmune Bullous Disease Quality of Life Questionnaires (ABQOL, TABQOL, DLQI) and Disease Severity Indices in Pemphigus and Bullous Pemphigoid

2020 ◽  
Author(s):  
Shan Cao ◽  
Lulu Sun ◽  
Zhongxiang Shi ◽  
Baoqi Yang ◽  
Furen Zhang
Keyword(s):  
Quality Of Life ◽  
Disease Severity ◽  
Bullous Pemphigoid ◽  
Strong Correlations ◽  
Disease Area ◽  
Area Index ◽  
Severity Of Disease ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease

Abstract Background: Pemphigus and bullous pemphigoid (BP) are autoimmune blistering diseases (AIBDs) that affect the skin and mucous membranes, and adversely impact quality of life (QOL). Few studies have assessed the correlation between the severity of disease and QOL in patients with pemphigus and BP. Objectives: To identify the correlation between the severity of AIBDs and QOL using the Autoimmune Bullous Disease Quality of Life (ABQOL), Treatment Autoimmune Bullous Disease Quality of Life (TABQOL), and Dermatology Life Quality Index (DLQI) questionnaires in Chinese patients with pemphigus and BP at baseline, and after 1, 3 and 6 months of treatment. Methods: Pemphigus and BP patients were invited to complete the ABQOL, TABQOL, and DLQI questionnaires. We measured the pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and antibodies of desmoglein1,desmoglein3 (DSG1/DSG3) for pemphigus; and the bullous pemphigoid disease area index (BPDAI), ABSIS, and antibodies of BP180/ BP230 for BP as disease severity indices. The correlations between the severity of disease and QOL were analyzed by Spearman’s correlation coefficient (r). Results: Eighty-five patients were included: 55 with pemphigus and 30 with BP. The pemphigus subtypes included pemphigus vulgaris (PV, n = 32), pemphigus foliaceus (PF, n = 22), and paraneoplastic pemphigus (PNP, n = 1). We found significantly strong correlations between QOL (ABQOL, TABQOL, DLQI) and severity of disease (PDAI/BPDAI, ABSIS) with (r = 0.87, 0.77, 0.83; r = 0.86, 0.73, 0.80) for pemphigus and BP, respectively. Mild or strong correlations were also observed between QOL and antibody titers in pemphigus with DSG1/DSG3(r=0.32/0.36) and BP with BP180/BP230( r = 0.73/0.17) respectively. Conclusion: The QOL of patients with pemphigus and BP decreased with increased severity of the AIBDs. As the disease severity descended, so the QOL improved. The QOL indices should be used in clinical trials and to manage patients’ treatment, especially during the active disease stage, despite the mild correlation observed after 1 month of treatment.The PDAI to be better at assessing disease severity than the ABSIS in patients with pemphigus, and ABSIS are better than BPDAI in BP patients for correlation with the QOL indices.

Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous disease

2018 ◽  
Vol 142 (6) ◽  
pp. 1831-1842.e7 ◽  
Author(s):  
Stefanie Haeberle ◽  
Xiaoying Wei ◽  
Katja Bieber ◽  
Stephanie Goletz ◽  
Ralf J. Ludwig ◽  
...  
Keyword(s):  
T Cell ◽  
Bullous Pemphigoid ◽  
Regulatory T Cell ◽  
Bullous Pemphigoid Antigen ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease

scholarly journals Anti-P 200 pemphigoid – The most common floor binding subepidermal autoimmune bullous disease in a tertiary care center in south India

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
Reena Rai ◽  
J. Bede Anand ◽  
C. Shanmugasekar ◽  
P. Arunprasath ◽  
V. Chaitra ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Immunofluorescence Microscopy ◽  
Care Center ◽  
Tertiary Care ◽  
Target Antigen ◽  
Direct Immunofluorescence ◽  
Bullous Disease ◽  
Bullous Diseases ◽  
Split Skin ◽  
Laminin 332

Background: The pemphigoid group of diseases may present clinically and immunologically in a very similar fashion. Indirect immunofluorescence microscopy with readily available salt-split human skin in a BIOCHIP™ helps to classify these conditions as those with either with roof binding or floor binding of immunoreactants. Epidermolysis bullosa acquisita, anti-laminin 332 pemphigoid and anti-p200 pemphigoid show floor binding, while in the most frequent type of pemphigoid disease, bullous pemphigoid, epidermal side staining pattern is seen on salt-split skin Aims: The aim of the study was to detect the target antigens in sub-epidermal bullous diseases. Methods: Forty patients with bullous pemphigoid diagnosed by lesional histopathology and direct immunofluorescence microscopy were re-evaluated by a BIOCHIP™ mosaic containing both tissue substrates and recombinant target antigens. Sera with floor pattern staining on salt-split skin were further evaluated by immunoblotting with dermal extract. Results: Five patients with floor staining had anti-p200 pemphigoid. Limitations: We could not perform serration pattern analysis of direct immunofluorescence in our patients. Conclusion: Histopathology and direct immunofluorescence microscopy cannot differentiate between various entities of pemphigoid diseases. A multivariant approach using a BIOCHIP™ mosaic including salt-split skin followed by immunoblotting with dermal extract helps to identify the target antigen.

scholarly journals Bullous pemphigoid: Case report and review of literature​

2021 ◽  
pp. 125-128
Author(s):  
Shunmugavelu KARTHIK ◽  
Shanmugam ARASU ◽  
Srikanthan SRIRAM ◽  
Evangeline Cynthia DHINAKARAN ◽  
Yalamanchi ANUSHA ◽  
...  
Keyword(s):  
Case Report ◽  
Bullous Pemphigoid ◽  
Chief Complaint ◽  
Topical Steroids ◽  
Oral Lesions ◽  
Incisional Biopsy ◽  
Review Of Literature ◽  
The Past ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease

Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by subepithelial blistering mostly affecting elderly but may be seen in all ages. A 52-year-old female patient came with a chief complaint of itching, redness and ulcer in the hands and oral cavity for the past 2 weeks. The examination revealed ulcer- ated lesions in palate and buccal mucosa. Erythematous lesions were also seen in upper limb. Incisional biopsy was done and histological examination revealed bullous pemphigoid. The patient was immediately started with systemic and topical steroids and was continued for 3 weeks. The extra-oral lesions were healed and intraoral ulcerations subsided after 3 weeks.

Bullous Scabies Simulating Pemphigoid

2011 ◽  
Vol 15 (1) ◽  
pp. 55-57 ◽  
Author(s):  
T. Roxana Stan ◽  
Stefano Piaserico ◽  
Matteo Bordignon ◽  
Roberto Salmaso ◽  
Edoardo Zattra ◽  
...  
Keyword(s):  
Skin Lesion ◽  
Bullous Pemphigoid ◽  
Steroid Treatment ◽  
Social Conditions ◽  
Direct Immunofluorescence ◽  
Benzyl Benzoate ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease ◽  
Skin Specimen ◽  
Desmoglein 3

Background: Scabies is a contagious infestation affecting subjects of all ages, races, and social conditions. Objective: We report a case of a 79-year-old man who developed a bullous pemphigoid-like eruption. He presented to our unit 4 months after the onset of symptoms. An autoimmune bullous disease was suspected. Direct immunofluorescence on a skin specimen and anti-desmoglein 1, anti-desmoglein 3, and anti-bullous pemphigoid antigen 180 were negative. Surprisingly, the histology of a skin lesion demonstrated the presence of scabies, which was successfully treated with benzyl benzoate 20%. Conclusion: The diagnosis of bullous scabies should be considered for any bullous eruptions accompanied by papules and itching resistant to steroid treatment and with negative immunopathologic findings.

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