Epidermal permeability barrier function and sphingolipid content in the skin of sphingomyelin synthase 2 deficient mice

2018 ◽  
Vol 27 (8) ◽  
pp. 827-832 ◽  
Author(s):  
Koji Nomoto ◽  
Yurina Itaya ◽  
Ken Watanabe ◽  
Tadashi Yamashita ◽  
Toshiro Okazaki ◽  
...  
Keyword(s):  
Barrier Function ◽  
Permeability Barrier ◽  
Sphingomyelin Synthase ◽  
Epidermal Permeability Barrier ◽  
Deficient Mice

Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice

2021 ◽  
pp. 1-7
Author(s):  
Shota Sakai ◽  
Asami Makino ◽  
Akihito Nishi ◽  
Takeshi Ichikawa ◽  
Tadashi Yamashita ◽  
...  
Keyword(s):  
Plasma Membranes ◽  
Lamellar Body ◽  
Lipid Mediator ◽  
Permeability Barrier ◽  
Compensatory Mechanisms ◽  
Terrestrial Environment ◽  
Sphingomyelin Synthase ◽  
Epidermal Permeability Barrier ◽  
Deficient Mice

Sphingomyelin (SM) is a constituent of cellular membranes, while ceramides (Cer) produced from SM on plasma membranes serve as a lipid mediator that regulates cell proliferation, differentiation, and apoptosis. In the skin, SM also is a precursor of Cer, an important constituent of epidermal permeability barrier. We investigated the role of epidermal SM synthase (SMS)2, an isoform of SMS, which modulates SM and Cer levels on plasma membranes. Although SMS2-knockout (SMS2-KO) mice were not neonatal lethal, an ichthyotic phenotype with epidermal hyperplasia and hyperkeratosis was evident at birth, which persisted until 2 weeks of age. These mice showed abnormal lamellar body morphology and secretion, and abnormal extracellular lamellar membranes in the stratum corneum. These abnormalities were no longer evident by 4 weeks of age in SMS2-KO mice. Our study suggests that (1) exposure to a dry terrestrial environment initiates compensatory responses, thereby normalizing epidermal ichthyotic abnormalities and (2) that a nonlethal gene abnormality can cause an ichthyotic skin phenotype.

Beneficial effect of curcumin on epidermal permeability barrier function

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
HY Jeon ◽  
JK Kim ◽  
JE Lee ◽  
WG Kim ◽  
SJ Lee
Keyword(s):  
Beneficial Effect ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Epidermal Permeability Barrier

Permeability barrier function in STAT6-deficient mice is superior to that in wild-type mice

2017 ◽  
Vol 86 (2) ◽  
pp. e41
Author(s):  
Wei Zhang ◽  
Takashi Sakai ◽  
Haruna Matsuda-Hirose ◽  
Yutaka Hatano
Keyword(s):  
Barrier Function ◽  
Permeability Barrier ◽  
Wild Type ◽  
Deficient Mice

Cutaneous permeability barrier function in signal transducer and activator of transcription 6-deficient mice is superior to that in wild-type mice

2018 ◽  
Vol 92 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Wei Zhang ◽  
Takashi Sakai ◽  
Haruna Matsuda-Hirose ◽  
Mizuki Goto ◽  
Tomoko Yamate ◽  
...  
Keyword(s):  
Barrier Function ◽  
Permeability Barrier ◽  
Signal Transducer ◽  
Wild Type ◽  
Deficient Mice

scholarly journals A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin

2011 ◽  
Vol 20 (3) ◽  
pp. 285-288 ◽  
Author(s):  
Mona Man ◽  
Melanie Hupe ◽  
Donald Mackenzie ◽  
Hyunjung Kim ◽  
Yuko Oda ◽  
...  
Keyword(s):  
Barrier Function ◽  
Permeability Barrier ◽  
Herbal Mixture ◽  
Chinese Herbal ◽  
Epidermal Permeability Barrier
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